| Title: |
Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study |
| Authors: |
Kudere, Nicole M; Choueiri, Toni K; Shah, Dimpy P; Shyr, Yu; Rubinstein, Samuel M; Rivera, Donna R; Shete, Sanjay; Hsu, Chih-Yuan; Desai, Aakash; Lima Lopes Jr, Gilberto de; Grivas, Petros; Painter, Corrie A; Peters, Solange; Thompson, Michael A; Bakouny, Ziad; Batist, Gerald; Bekaii-Saab, Tanios; Bilen, Mehmet A; Bouganim, Nathaniel; Bover Larroya, Mateo; Castellano, Daniel; Del Prete, Salvatore A; Doroshow, Deborah B; Egan, Pamela C; Elkrief, Arielle; Farmakiotis, Dimitrios; Flora, Daniel; Galsky, Matthew D; Glover, Michael J; Griffiths, Elizabeth A; Gulati, Anthony P; Gupta, Shilpa; Hafez, Navid; Halfdanarson, Thorvardur R; Hawley, Jessica E; Hsu, Emily; Kasi, Anup; Khaki, Ali R; Lemmon, Christopher A; Lewis, Colleen; Logan, Barbara; Masters, Tyler; McKay, Rana R; Mesa, Ruben A; Morgans, Alicia K; Mulcahy, Mary F; Panagiotou, Orestis A; Peddi, Prakash; Pennell, Nathan A; Reynolds, Kerry; Rosen, Lane R; Rosovsky, Rachel; Salazar, Mary; Schmidt, Andrew; Shah, Sumit A; Shaya, Justin A; Steinharter, John; Stockerl-Goldstein, Keith E; Subbiah, Suki; Vinh, Donald C; Wehbe, Firas H; Weissmann, Lisa B; Tsu-Yu Wu, Julie; Wulff-Burchfield, Elizabeth; Xie, Zhuoer; Yeh, Albert; Yu, Peter P; Zhou, Alice Y; Zubiri, Leyre; Mishra, Sanjay; Lyman, Gary H; Rini, Brian I; Warner, Jeremy L |
| Source: |
reponame:Expeditio Repositorio Institucional UJTL ; instname:Universidad de Bogotá Jorge Tadeo Lozano |
| Publisher Information: |
Science Direct |
| Publication Year: |
2020 |
| Collection: |
Expeditio - Repositorio Institucional Universidad de Bogotá Jorge Tadeo Lozano (UTADEO) |
| Subject Terms: |
Clinical impact of COVID-19; COVID-19; Patients with cancer; Síndrome respiratorio agudo grave; SARS-CoV-2; Coronavirus |
| Description: |
Background Data on patients with COVID-19 who have cancer are lacking. Here we characterise the outcomes of a cohort of patients with cancer and COVID-19 and identify potential prognostic factors for mortality and severe illness. Methods In this cohort study, we collected de-identified data on patients with active or previous malignancy, aged 18 years and older, with confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection from the USA, Canada, and Spain from the COVID-19 and Cancer Consortium (CCC19) database for whom baseline data were added between March 17 and April 16, 2020. We collected data on baseline clinical conditions, medications, cancer diagnosis and treatment, and COVID-19 disease course. The primary endpoint was all-cause mortality within 30 days of diagnosis of COVID-19. We assessed the association between the outcome and potential prognostic variables using logistic regression analyses, partially adjusted for age, sex, smoking status, and obesity. This study is registered with ClinicalTrials.gov, NCT04354701, and is ongoing. Findings Of 1035 records entered into the CCC19 database during the study period, 928 patients met inclusion criteria for our analysis. Median age was 66 years (IQR 57–76), 279 (30%) were aged 75 years or older, and 468 (50%) patients were male. The most prevalent malignancies were breast (191 [21%]) and prostate (152 [16%]). 366 (39%) patients were on active anticancer treatment, and 396 (43%) had active (measurable) cancer. At analysis (May 7, 2020), 121 (13%) patients had died. In logistic regression analysis, independent factors associated with increased 30-day mortality, after partial adjustment, were: increased age (per 10 years; partially adjusted odds ratio 1·84, 95% CI 1·53–2·21), male sex (1·63, 1·07–2·48), smoking status (former smoker vs never smoked: 1·60, 1·03–2·47), number of comorbidities (two vs none: 4·50, 1·33–15·28), Eastern Cooperative Oncology Group performance status of 2 or higher (status of 2 vs 0 or 1: 3·89, 2·11–7·18), ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
12 páginas; image/jepg; image/png; application/pdf |
| Language: |
unknown |
| Relation: |
https://doi.org/10.1016/; http://hdl.handle.net/20.500.12010/10698 |
| DOI: |
10.1016/ |
| Availability: |
https://hdl.handle.net/20.500.12010/10698; https://doi.org/10.1016/ |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.1F04A686 |
| Database: |
BASE |