| Title: |
Effect of nintedanib in patients with systemic sclerosis-associated interstitial lung disease and risk factors for rapid progression |
| Authors: |
Khanna, Dinesh; Maher, Toby M; Volkmann, Elizabeth R; Allanore, Yannick; Smith, Vanessa; Assassi, Shervin; Kreuter, Michael; Hoffmann-Vold, Anna-Maria; Kuwana, Masataka; Stock, Christian; Alves, Margarida; Sambevski, Steven; Denton, Christopher P |
| Source: |
RMD Open , 9 (1) , Article e002859. (2023) |
| Publisher Information: |
BMJ |
| Publication Year: |
2023 |
| Collection: |
University College London: UCL Discovery |
| Subject Terms: |
Autoimmune Diseases; Pulmonary Fibrosis; Scleroderma; Systemic; Therapeutics |
| Description: |
OBJECTIVE: To investigate the rate of decline in forced vital capacity (FVC), and the effect of nintedanib on the rate of decline in FVC, in subjects with systemic sclerosis-associated interstitial lung disease (SSc-ILD) who had risk factors for rapid decline in FVC. METHODS: The SENSCIS trial enrolled subjects with SSc and fibrotic ILD of ≥10% extent on high-resolution CT. The rate of decline in FVC over 52 weeks was analysed in all subjects and in those with early SSc ( |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://discovery.ucl.ac.uk/id/eprint/10165424/1/e002859.full.pdf; https://discovery.ucl.ac.uk/id/eprint/10165424/ |
| Availability: |
https://discovery.ucl.ac.uk/id/eprint/10165424/1/e002859.full.pdf; https://discovery.ucl.ac.uk/id/eprint/10165424/ |
| Rights: |
open |
| Accession Number: |
edsbas.1F4D6FDB |
| Database: |
BASE |