| Title: |
Incident ischaemic stroke and Type 2 diabetes:trends in incidence and case fatality in Scotland 2004-2013 |
| Authors: |
Read, S. H.; McAllister, D. A.; Colhoun, H. M.; Farran, B.; Fischbacher, C.; Kerssens, J. J.; Leese, G. P.; Lindsay, R. S.; McCrimmon, R. J.; McGurnaghan, S.; Philip, S.; Sattar, N.; Wild, S. H. |
| Source: |
Read, S H, McAllister, D A, Colhoun, H M, Farran, B, Fischbacher, C, Kerssens, J J, Leese, G P, Lindsay, R S, McCrimmon, R J, McGurnaghan, S, Philip, S, Sattar, N, Wild, S H & Scottish Diabetes Research Network Epidemiology Group 2018, 'Incident ischaemic stroke and Type 2 diabetes : trends in incidence and case fatality in Scotland 2004-2013', Diabetic Medicine, vol. 35, no. 1, pp. 99-106. https://doi.org/10.1111/dme.13528 |
| Publication Year: |
2018 |
| Collection: |
Discovery - University of Dundee Online Publications |
| Subject Terms: |
Adolescent; Adult; Aged; 80 and over; Brain Ischemia/complications; Cohort Studies; Diabetes Mellitus; Type 2/epidemiology; Female; Humans; Incidence; Logistic Models; Male; Middle Aged; Mortality; Retrospective Studies; Scotland/epidemiology; Stroke/epidemiology; Young Adult; /dk/atira/pure/subjectarea/asjc/1300/1310; name=Endocrinology; /dk/atira/pure/subjectarea/asjc/2700/2724; name=Internal Medicine; /dk/atira/pure/subjectarea/asjc/2700/2712; Diabetes and Metabolism |
| Description: |
Aim : To describe trends in first ischaemic stroke incidence and case fatality in adults with and without a diagnosis of Type 2 diabetes prior to their ischaemic stroke event in Scotland between 2004 and 2013. Methods : Using population-wide hospital admission, death and diabetes datasets, we conducted a retrospective cohort study. Negative binomial and logistic regression models were used to calculate year-specific incidence and case-fatality rates for people with Type 2 diabetes and for people without diabetes. Results : During 41.0 million person-years of follow-up there were 69 757 ischaemic stroke events. Type 2 diabetes prevalence among patients who experienced ischaemic stroke increased from 13.5% to 20.3% between 2004 and 2013. Stroke incidence rates declined by 2.7% (95% CI 2.4, 3.0) annually for people with and without diabetes [diabetes/year interaction: rate ratio 0.99 (95% CI 0.98, 1.01)]. Type 2 diabetes was associated with an increased risk of ischaemic stroke in men [rate ratio 1.23 (95% CI 1.17, 1.30)] and women [rate ratio 1.41 (95% CI 1.35, 1.48)]. Case-fatality rates were 14.2% and 12.7% in people with Type 2 diabetes and without diabetes, respectively. Case fatality declined by 3.5% (95% CI 2.7, 4.5) annually [diabetes/year interaction: odds ratio 1.01 (95% CI 0.98, 1.02)]. Conclusions : Ischaemic stroke incidence declined no faster in people with a diagnosis of Type 2 diabetes than in people without diabetes. Increasing prevalence of Type 2 diabetes among stroke patients may mean that declines in case fatality over time will be less marked in the future. This article is protected by copyright. All rights reserved. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
0742-3071; 1464-5491 |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/29044687; info:eu-repo/semantics/altIdentifier/pissn/0742-3071; info:eu-repo/semantics/altIdentifier/eissn/1464-5491 |
| DOI: |
10.1111/dme.13528 |
| Availability: |
https://discovery.dundee.ac.uk/en/publications/44a1f122-1459-44e3-b42f-712796f4aa0e; https://doi.org/10.1111/dme.13528; https://discovery.dundee.ac.uk/ws/files/19766582/S.Read_Diabetic_Medicine_revised2.pdf; https://www.scopus.com/pages/publications/85032928263 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.1F680790 |
| Database: |
BASE |