| Title: |
Prognostic value of visually and computationally assessed tumor-infiltrating lymphocytes in early-stage triple-negative breast cancer (TBCRC-030) |
| Authors: |
Nader-Marta, Guilherme; Chu, Xiangying; Mukhopadhyay, Satabhisa; Abramson, Vandana G; Brufsky, Adam; Stringer-Reasor, Erica Michelle; Dent, Susan Faye; Traina, Tiffany A; Carey, Lisa A; Rimawi, Mothaffar F; Specht, Jennifer M; Miller, Kathy D; Santa-Maria, Cesar Augusto; Dasgupta, Tathagata; Kurt, Busem Binboğa; DeMeo, Michelle; Krop, Ian E; Tung, Nadine M; Schnitt, Stuart J; Tayob, Nabihah; Mayer, Erica L |
| Contributors: |
TBCRC; Breast Cancer Research Foundation |
| Source: |
JNCI: Journal of the National Cancer Institute ; volume 118, issue 1, page 141-149 ; ISSN 0027-8874 1460-2105 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2025 |
| Description: |
Background Tumor-infiltrating lymphocytes (TILs), assessed by visual examination, are prognostic and predictive in early-stage triple-negative breast cancer. Computational assessment may provide a complementary approach. We evaluated the prognostic value of TILs by visual examination and computational assessment. Methods Cisplatin vs Paclitaxel for Triple Negative Breast Cancer (TBCRC030; ClinicalTrials.gov identifier NCT01982448) was a randomized phase 2 trial enrolling patients with BRCA1/2-proficient stage I to III triple-negative breast cancer to receive preoperative cisplatin or paclitaxel. The primary endpoint was pathological response at surgery. The TILs were visually scored on digitized pretreatment biopsies per International TILS Working Group recommendations. Computational assessment used the 4D Path QPOR platform to generate TILs, an immune heterogeneity index, and a combined immune/cell cycle biomarker (CmbI). Predictive performance for residual cancer burden 0/1 was assessed using receiver operating characteristic curves and odds ratios (ORs) with 95% CIs; all statistical tests were 2-sided. Results Of 139 response-evaluable patients, 121 had matched visual examination and computational assessment data (59 on cisplatin, 62 on paclitaxel). Median visual examination TILs were higher in responders (40.0% vs. 10.0%; P = .002) and predicted response (OR = 1.86, 95% CI = 1.24 to 2.87; area under the curve = 0.69, 95% CI = 0.57 to 0.80). Computational assessment CmbI differed by response group and predicted residual cancer burden 0/1 (OR = 3.20, 95% CI = 1.05 to 11.07; area under the curve = 0.62, 95% CI = 0.51 to 0.73). Computational assessment TILs and immune heterogeneity index were not predictive. Visual examination TILs and computational assessment CmbI predicted response to paclitaxel (OR = 2.91, 95% CI = 1.56 to 6.14; OR = 9.17, 95% CI = 2.01 to 66.39, respectively) but not to cisplatin. Conclusion Visual examination TILs and computational assessment CmbI were each associated with response ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1093/jnci/djaf289 |
| DOI: |
10.1093/jnci/djaf289/64639385/djaf289.pdf |
| Availability: |
https://doi.org/10.1093/jnci/djaf289; https://academic.oup.com/jnci/advance-article-pdf/doi/10.1093/jnci/djaf289/64639385/djaf289.pdf; https://academic.oup.com/jnci/article-pdf/118/1/141/64639385/djaf289.pdf |
| Rights: |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.1F8A6B6C |
| Database: |
BASE |