| Title: |
High Frequency of Specific Polysaccharide Antibody Deficiency in Adults With Unexplained, Recurrent and/or Severe Infections With Encapsulated Bacteria |
| Authors: |
Stabler, Sarah; Lamblin, Catherine; Gaillard, Sacha; Just, Nicolas; Mihailescu, Mirela; Viget, Nathalie; Sy Ndiaye, Thierno; Dzeing Ella, Arnaud; Brunin, Guillaume; Weyrich, Pierre; Prevotat, Anne; Chenivesse, Cécile; Le Rouzic, Olivier; Mortuaire, Geoffrey; Vuotto, Fanny; Faure, Karine; Leurs, Amélie; Wallet, Frédéric; Loiez, Caroline; Titecat, Marie; Le Guern, Rémi; Hachulla, Eric; Sanges, Sébastien; Etienne, Nicolas; Terriou, Louis; Launay, David; Lopez, Benjamin; Bahuaud, Mathilde; Batteux, Frédéric; Dubucquoi, Sylvain; Gesquière-Lasselin, Cyrielle; Labalette, Myriam; Lefèvre, Guillaume |
| Contributors: |
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 (CIIL); Institut Pasteur de Lille; Pasteur Network (Réseau International des Instituts Pasteur)-Pasteur Network (Réseau International des Instituts Pasteur)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS); Ramsay Générale de Santé - Hôpital Privé La Louvière; Centre Hospitalier de Roubaix; Centre Hospitalier Gustave Dron Tourcoing; Centre Hospitalier Boulogne-sur-mer; Groupe Hospitalier de l'Institut Catholique de Lille (GHICL); Université catholique de Lille (UCL); Service de Pneumologie et Immuno-Allergologie CHU LIlle; Pole Cardio-vasculaire et pulmonaire CHU Lille; Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille)-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille); Institute for Translational Research in Inflammation - U 1286 (INFINITE); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille); Hôpital Claude Huriez Lille; Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille); ISA-Chromatography & Hyphenated Techniques - Chromatographie et techniques couplées; Institut des Sciences Analytiques (ISA); Université Claude Bernard Lyon 1 (UCBL); Université de Lyon-Université de Lyon-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL); Université de Lyon-Université de Lyon-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS); CH Dunkerque; AGroécologie, Innovations, teRritoires (AGIR); Institut National Polytechnique (Toulouse) (Toulouse INP); Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Ecole d'Ingénieurs de Purpan (INP - PURPAN); Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE); Institut Pasteur Paris (IP); Centre National de Référence des Maladies Auto-Immunes Systémiques Rares du Nord et Nord-Ouest de France (CeRAINO) |
| Source: |
ISSN: 1058-4838. |
| Publisher Information: |
CCSD; Oxford University Press (OUP) |
| Publication Year: |
2023 |
| Collection: |
Université Toulouse III - Paul Sabatier: HAL-UPS |
| Subject Terms: |
[SDV]Life Sciences [q-bio] |
| Description: |
International audience ; Abstract Background Primary immunodeficiencies (PIDs) in adults are mainly revealed by recurrent and/or severe bacterial infections. The objective of this study was to evaluate a systematic research strategy of PIDs in adults with unexplained bacterial infections, with a special focus on specific polysaccharide antibody deficiency (SPAD). Methods In this prospective multicenter study, inclusion criteria were recurrent benign upper and lower respiratory tract infections (RTIs) for at least two years (group 1), at least one upper or lower RTI requiring hospitalization (group 2), and/or at least one invasive infection documented with encapsulated bacteria (group 3). Main exclusion criteria were all local and general conditions that could explain infections. If no PID diagnosis was made, response to polysaccharide antigens was assessed using a pneumococcal polysaccharide vaccine. Results From March 2015 to March 2020, 118 patients were included (37 males, median age of 41 years): 73, 17, and 28 in groups 1, 2, and 3, respectively. Forty-seven PIDs were diagnosed, giving an estimated frequency of 39.8% (95% confidence interval [CI] [30.4, 48.8]). SPAD was the most frequent diagnosis by far (n = 37/47, 78.7%), and was made in 23, 5, and 9 patients from groups 1 to 3, respectively. All SPAD patients received conjugate vaccines and, according to their infectious history, were on surveillance or treated with preventive antibiotics (n = 6) and/or with immunoglobulins replacement therapy (n = 10), the latter being dramatically efficient in all cases. Conclusions Considering its high prevalence among adults with unexplained recurrent and/or severe bacterial infections, SPAD should be screened in those patients. Clinical Trials Registration NCT02972281. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1093/cid/ciac842 |
| Availability: |
https://hal.science/hal-05285112; https://doi.org/10.1093/cid/ciac842 |
| Accession Number: |
edsbas.1FC94D48 |
| Database: |
BASE |