| Title: |
Mechanical ventilation in patients with cardiogenic pulmonary edema: a sub-analysis of the LUNG SAFE study |
| Authors: |
Amado-Rodríguez, Laura; Rodríguez-Garcia, Raquel; Bellani, Giacomo; Pham, Tài; Fan, Eddy; Madotto, Fabiana; Laffey, John, G; Albaiceta, Guillermo, M; Pesenti, Antonio; Brochard, Laurent; Esteban, Andres; Gattinoni, Luciano; van Haren, Frank; Larsson, Anders; Mcauley, Daniel, F; Ranieri, Marco; Rubenfeld, Gordon; Taylor Thompson, B; Wrigge, Hermann; Slutsky, Arthur, S; Rios, Fernando; Sottiaux, Thierry; Depuydt, Pieter; Lora, Fredy, S; Azevedo, Luciano, Cesar; Bugedo, Guillermo; Qiu, Haibo; Gonzalez, Marcos; Silesky, Juan; Cerny, Vladimir; Nielsen, Jonas; Jibaja, Manuel; Matamis, Dimitrios; Ranero, Jorge, Luis; Amin, Pravin; Hashemian, S, M; Clarkson, Kevin; Kurahashi, Kiyoyasu; Villagomez, Asisclo; Zeggwagh, Amine, Ali; Heunks, Leo, M; Laake, Jon, Henrik; Palo, Jose, Emmanuel; Do Vale Fernandes, Antero; Sandesc, Dorel; Arabi, Yaasen; Bumbasierevic, Vesna; Nin, Nicolas; Lorente, Jose, A; Piquilloud, Lise; Abroug, Fekri; Mcnamee, Lia; Hurtado, Javier; Bajwa, Ed; Démpaire, Gabriel; Sula, Hektor; Nunci, Lordian; Cani, Alma; Zazu, Alan; Dellera, Christian; Insaurralde, Carolina, S; Las Lomas, Sanatorio; Isidro, San; Alejandro, Risso, V; Daldin, Julio; Vinzio, Mauricio; Fernandez, Ruben, O; Cardonnet, Luis, P; Bettini, Lisandro, R; Bisso, Mariano, Carboni; Osman, Emilio, M; Setten, Mariano, G; Lovazzano, Pablo; Alvarez, Javier; Villar, Veronica; Pozo, Norberto, C; Grubissich, Nicolas; Plotnikow, Gustavo, A; Vasquez, Daniela, N; Ilutovich, Santiago; Tiribelli, Norberto; Chena, Ariel; Pellegrini, Carlos, A; Saenz, María, G; Estenssoro, Elisa; Brizuela, Matias; Gianinetto, Hernan; Gomez, Pablo, E; Cerrato, Valeria, I; Bezzi, Marco, G; Borello, Silvina, A; Loiacono, Flavia, A; Fernandez, Adriana, M; Knowles, Serena; Reynolds, Claire; Inskip, Deborah, M; Miller, Jennene, J; Kong, Jing; Whitehead, Christina; Bihari, Shailesh; Seven, Aylin; Krstevski, Amanda; Rodgers, Helen, J; Millar, Rebecca, T; Mckenna, Toni, E; Bailey, Irene, M; Hanlon, Gabrielle, C; Aneman, Anders; Lynch, Joan, M; Azad, Raman; Neal, John; Woods, Paul, W; Roberts, Brigit, L; Kol, Mark, R; Wong, Helen, S; Riss, Katharina, C; Staudinger, Thomas; Wittebole, Xavier; Berghe, Caroline; Bulpa, Pierre, A; Dive, Alain, M; Verstraete, Rik; Lebbinck, Herve; Vermassen, Joris; Meersseman, Philippe; Ceunen, Helga; Rosa, Jonas, I; Beraldo, Daniel, O; Piras, Claudio; Rampinelli, Adenilton, M; Nassar Jr, Antonio, P; Mataloun, Sergio; Moock, Marcelo; Thompson, Marlus, M; Gonçalves, Claudio, H; Antônio, Ana, Carolina P; Ascoli, Aline; Biondi, Rodrigo, S; Fontenele, Danielle, C; Nobrega, Danielle; Sales, Vanessa, M; Binhjabul Wahab, Ahmad, Yazid; Ismail, Maizatul; Shindhe, Suresh; Beloncle, Francois; Davies, Kyle, G; Cirone, Rob; Manoharan, Venika; Ismail, Mehvish; Goligher, Ewan, C; Jassal, Mandeep; Nishikawa, Erin; Javeed, Areej; Curley, Gerard; Rittayamai, Nuttapol; Parotto, Matteo; Ferguson, Niall, D; Mehta, Sangeeta; Knoll, Jenny; Pronovost, Antoine; Canestrini, Sergio; Bruhn, Alejandro, R; Garcia, Patricio, H; Aliaga, Felipe, A; Farías, Pamela, A; Yumha, Jacob, S; Ortiz, Claudia, A; Salas, Javier, E; Saez, Alejandro, A; Vega, Luis, D; Labarca, Eduardo, F; Martinez, Felipe, T; Carreño, Nicolás, G; Lora, Pilar; Liu, Haitao; Liu, Ling; Tang, Rui; Luo, Xiaoming; An, Youzhong; Zhao, Huiying; Gao, Yan; Zhai, Zhe; Ye, Zheng, L; Wang, Wei; Li, Wenwen; Li, Qingdong; Zheng, Ruiqiang; Yu, Wenkui; Shen, Juanhong; Li, Xinyu; Yu, Tao; Lu, Weihua; Wu, Ya, Q; Huang, Xiao, B; He, Zhenyang; Lu, Yuanhua; Han, Hui; Zhang, Fan; Sun, Renhua; Wang, Hua, X; Qin, Shu, H; Zhu, Bao, H; Zhao, Jun; Liu, Jian; Li, Bin; Liu, Jing, L; Zhou, Fa, C; Li, Qiong, J; Zhang, Xing, Y; Li-Xin, Zhou; Xin-Hua, Qiang; Jiang, Liangyan; Gao, Yuan, N; Zhao, Xian, Y; Li, Yuan, Y; Li, Xiao, L; Wang, Chunting; Yao, Qingchun; Yu, Rongguo; Chen, Kai; Shao, Huanzhang; Qin, Bingyu; Huang, Qing, Q; Zhu, Wei, H; Hang, Ai, Y; Hua, Ma, X; Li, Yimin; Xu, Yonghao; Di, Yu, D; Ling, Long, L; Qin, Tie, H; Wang, Shou, H; Qin, Junping; Han, Yi; Zhou, Suming; Vargas, Monica, P; Jimenez, Juan, I Silesky; Rojas, Manuel, a González; Solisquesada, Jaime, E; Ramirez-Alfaro, Christian, M; Máca, Jan; Sklienka, Peter; Gjedsted, Jakob; Christiansen, Aage; Villamagua, Boris, G; Llano, Iguel; Burtin, Philippe; Buzancais, Gautier; Beuret, Pascal; Pelletier, Nicolas; Mortaza, Satar; Mercat, Alain; Chelly, Jonathan; Jochmans, Sébastien; Terzi, Nicolas; Daubin, Cédric; Carteaux, Guillaume; de Prost, Nicolas; Chiche, Jean-Daniel; Daviaud, Fabrice; Fartoukh, Muriel; Barberet, Guillaume; Biehler, Jerome; Dellamonica, Jean; Doyen, Denis; Arnal, Jean-Michel; Briquet, Anais; Hraiech, Sami; Papazian, Laurent; Follin, Arnaud; Roux, Damien; Messika, Jonathan; Kalaitzis, Evangelos; Dangers, Laurence; Combes, Alain; Béduneau, Gaetan; Carpentier, Dorothée; Zogheib, Elie, H; Dupont, Herve; Ricome, Sylvie; Santoli, Francesco, L; Besset, Sebastien, L; Michel, Philippe; Gelée, Bruno; Danin, Pierre-Eric; Goubaux, Bernard; Crova, Philippe, J; Phan, Nga, T; Berkelmans, Frantz; Badie, Julio, C; Tapponnier, Romain; Gally, Josette; Khebbeb, Samy; Herbrecht, Jean-Etienne; Schneider, Francis; Declercq, Pierrelouis, M; Rigaud, Jean-Philippe; Duranteau, Jacques; Harrois, Anatole; Chabanne, Russell; Marin, Julien; Bigot, Charlene; Thibault, Sandrine; Ghazi, Mohammed; Boukhazna, Messabi; Zein, Salem, Ould; Richecoeur, Jack, R; Combaux, Daniele, M; Grelon, Fabien; Le Moal, Charlene; Sauvadet, Elise, P; Robine, Adrien; Lemiale, Virginie; Reuter, Danielle; Dres, Martin; Demoule, Alexandre; Goldgran-Toledano, Dany; Baboi, Loredana; Guérin, Claude; Lohner, Ralph; Kraßler, Jens; Schäfer, Susanne; Zacharowski, Kai, D; Meybohm, Patrick; Reske, Andreas, W; Simon, Philipp; Hopf, Hansbernd, F; Schuetz, Michael; Baltus, Thomas; Papanikolaou, Metaxia, N; Papavasilopoulou, Theonymfi, G; Zacharas, Giannis, A; Ourailogloy, Vasilis; Mouloudi, Eleni, K; Massa, Eleni, V; Nagy, Eva, O; Stamou, Electra, E; Kiourtzieva, Ellada, V; Oikonomou, Marina, A; Avila, Luis, E; Cortez, Cesar, A; Citalán, Johanna, E; Jog, Sameer, A; Sable, Safal, D; Shah, Bhagyesh; Gurjar, Mohan; Baronia, Arvind, K; Memon, Mohammedfaruk; Muthuchellappan, Radhakrishnan; Ramesh, Venkatapura, J; Shenoy, Anitha; Unnikrishnan, Ramesh; Dixit, Subhal, B; Rhayakar, Rachana, V; Ramakrishnan, Nagarajan; Bhardwaj, Vallish, K; Mahto, Heera, L; Sagar, Sudha, V; Palaniswamy, Vijayanand; Ganesan, Deeban; Hashemian, Seyed, Mohammadreza; Jamaati, Hamidreza; Heidari, Farshad; Meaney, Edel, A; Nichol, Alistair; Knapman, Karl, M; O’croinin, Donall; Dunne, Eimhin, S; Breen, Dorothy, M; Clarkson, Kevin, P; Jaafar, Rola, F; Dwyer, Rory; Amir, Fahd; Ajetunmobi, Olaitan, O; O’muircheartaigh, Aogan, C; Black, Colin, S; Treanor, Nuala; Collins, Daniel, V; Altaf, Wahid; Zani, Gianluca; Fusari, Maurizio; Spadaro, Savino; Volta, Carlo, A; Graziani, Romano; Brunettini, Barbara; Palmese, Salvatore; Formenti, Paolo; Umbrello, Michele; Lombardo, Andrea; Pecci, Elisabetta; Botteri, Marco; Savioli, Monica; Protti, Alessandro; Mattei, Alessia; Schiavoni, Lorenzo; Tinnirello, Andrea; Todeschini, Manuel; Giarratano, Antonino; Cortegiani, Andrea; Sher, Sara; Rossi, Anna; Antonelli, Massimo, M; Montini, Luca, M; Casalena, Paolo; Scafetti, Sergio; Panarello, Giovanna; Occhipinti, Giovanna; Patroniti, Nicolò; Pozzi, Matteo; Biscione, Roberto, R; Poli, Michela, M; Raimondi, Ferdinando; Albiero, Daniela; Crapelli, Giulia; Beck, Eduardo; Pota, Vincenzo; Schiavone, Vincenzo; Molin, Alexandre; Tarantino, Fabio; Monti, Giacomo; Frati, Elena; Mirabella, Lucia; Cinnella, Gilda; Fossali, Tommaso; Colombo, Riccardo; Terragni, Pierpaolo; Pattarino, Ilaria; Mojoli, Francesco; Braschi, Antonio; Borotto, Erika, E; Cracchiolo, Andrea, N; Palma, Daniela, M; Raponi, Francesco; Foti, Giuseppe; Vascotto, Ettore, R; Coppadoro, Andrea; Brazzi, Luca; Floris, Leda; Iotti, Giorgio, A; Venti, Aaron; Yamaguchi, Osamu; Takagi, Shunsuke; Maeyama, Hiroki, N; Watanabe, Eizo; Yamaji, Yoshihiro; Shimizu, Kazuyoshi; Shiozaki, Kyoko; Futami, Satoru; Ryosuke, Sekine; Saito, Koji; Kameyama, Yoshinobu; Ueno, Keiko; Izawa, Masayo; Okuda, Nao; Suzuki, Hiroyuki; Harasawa, Tomofumi; Nasu, Michitaka; Takada, Tadaaki; Ito, Fumihito; Nunomiya, Shin; Koyama, Kansuke; Abe, Toshikazu; Andoh, Kohkichi; Kusumoto, Kohei; Hirata, Akira; Takaba, Akihiro; Kimura, Hiroyasu; Matsumoto, Shuhei; Higashijima, Ushio; Honda, Hiroyuki; Aoki, Nobumasa; Imai, Hiroshi; Ogino, Yasuaki; Mizuguchi, Ichiko; Ichikado, Kazuya; Nitta, Kenichi; Mochizuki, Katsunori; Hashida, Tomoaki; Tanaka, Hiroyuki; Nakamura, Tomoyuki; Niimi, Daisuke; Ueda, Takeshi; Kashiwa, Yozo; Uchiyama, Akinori; Sabelnikovs, Olegs; Oss, Peteris; Haddad, Youssef; Liew, Kong, Y; Ñamendys-Silva, Silvio, A; Jarquin-Badiola, Yves, D; Sanchez-Hurtado, Luis, A; Gomez-Flores, Saira, S; Marin, Maria, C; Villagomez, Asisclo, J; Lemus, Jordana, S; Fierro, Jonathan, M; Cervantes, Mavy, Ramirez; Mejia, Francisco, Javier Flores; Dector, Dulce; Rojas, Alejandro; Gonzalez, Daniel, R; Estrella, Claudia, R; Sanchez-Medina, Jorge, R; Ramirez-Gutierrez, Alvaro; George, Fernando, G; Aguirre, Janet, S; Buensuseso, Juan, A; Poblano, Manuel; Dendane, Tarek; Balkhi, Hicham; Elkhayari, Mina; Samkaoui, Nacer; Ezzouine, Hanane; Benslama, Abdellatif; Amor, Mourad; Maazouzi, Wajdi; Cimic, Nedim; Beck, Oliver; Bruns, Monique, M; Schouten, Jeroen, A; Rinia, Myra; Raaijmakers, Monique; van Wezel, Hellen, M; Heines, Serge, J; Strauch, Ulrich; Buise, Marc, P; Simonis, Fabienne, D; Schultz, Marcus, J; Goodson, Jennifer, C; Browne, Troy, S; Navarra, Leanlove; Hunt, Anna; Hutchison, Robyn, A; Bailey, Mathew, B; Newby, Lynette; Mcarthur, Colin; Kalkoff, Michael; Mcleod, Alex; Casement, Jonathan; Hacking, Danielle, J; Andersen, Finn, H; Dolva, Merete, S; Laake, Jon, H; Barratt-Due, Andreas; Noremark, Kim, Andre L; Søreide, Eldar; Sjøbø, Brit, Å; Guttormsen, Anne, B; Leonyoshido, Hector, H; Aguilar, Ronald, Zumaran; Oscanoa, Fredy, a Montes; Alisasis, Alain, U; Robles, Joanne, B; Pasanting-Lim, Rossini, Abbie B; Tan, Beatriz, C; Andruszkiewicz, Pawel; Jakubowska, Karina; Coxo, Cristina, M; Alvarez, António, M; Oliveira, Bruno, S; Montanha, Gustavo, M; Barros, Nelson, C; Pereira, Carlos, S; Messias, António, M; Monteiro, Jorge, M; Araujo, Ana, M; Catorze, Nuno, T; Marum, Susan, M; Bouw, Maria, J; Gomes, Rui, M; Brito, Vania, A; Castro, Silvia; Estilita, Joana, M; Barros, Filipa, M; Serra, Isabel, M; Martinho, Aurelia, M; Tomescu, Dana, R; Marcu, Alexandra; Bedreag, Ovidiu, H; Papurica, Marius; Corneci, Dan, E; Negoita, Silvius, Ioan; Grigoriev, Evgeny; Gritsan, Alexey, I; Gazenkampf, Andrey, A; Almekhlafi, Ghaleb; Albarrak, Mohamad, M; Mustafa, Ghanem, M; Maghrabi, Khalid, A; Salahuddin, Nawal; Aisa, Tharwat, M; Aljabbary, Ahmed, S; Tabhan, Edgardo; Arabi, Yaseen, M; Trinidad, Olivia, A; Al Dorzi, Hasan, M; Tabhan, Edgardo, E; Bumbasirevic, Vesna; Jovanovic, Bojan; Bolon, Stefan; Smith, Oliver; Mancebo, Jordi; Aguirre-Bermeo, Hernan; Lopez-Delgado, Juan, C; Esteve, Francisco; Rialp, Gemma; Forteza, Catalina; de Haro, Candelaria; Artigas, Antonio; de Cima-Iglesias, Sara; Seoane-Quiroga, Leticia; Ceniceros-Barros, Alexandra; Ruizaguilar, Antonio, L; Claraco-Vega, Luis, M; Soler, Juan, Alfonso; del Carmenlorente, Maria; Hermosa, Cecilia; Gordo, Federico; Prietogonzález, Miryam; López-Messa, Juan, B; Perez, Manuel, P; Perez, Cesar, P; Allue, Raquel, Montoiro; Rochecampo, Ferran; Ibañez-Santacruz, Marcos; Temprano, Susana; Pintado, Maria, C; de Pablo, Raul; Gómez, Pilar, Ricart Aroa; Ruiz, Silvia, Rodriguez; Moles, Silvia, Iglesias; Jurado, M, Teresa; Arizmendi, Alfons; Piacentini, Enrique, A; Franco, Nieves; Honrubia, Teresa; Cheng, Meisy, Perez; Losada, Elena, Perez; Blanco, Javier; Yuste, Luis, J; Carbayo-Gorriz, Cecilia; Cazorla-Barranquero, Francisca, G; Alonso, Javier, G; Alda, Rosa, S; Algaba, Ángela; Navarro, Gonzalo; Cereijo, Enrique; Diaz-Rodriguez, Esther; Marcos, Diego, Pastor; Montero, Laura, Alvarez; Para, Luis, Herrera; Sanchez, Roberto, Jimenez; Navalpotro, Miguel, Angel Blasco; Abad, Ricardo, Diaz; González, Raquel, Montiel; Toribio, Dácil, Parrilla; Castro, Alejandro, G; Artiga, Maria, Jose D; Penuelas, Oscar; Roser, Tomas, P; Olga, Moreno, F; Curto, Elena, Gallego; Sánchez, Rocío, Manzano; Imma, Vallverdu, P; Elisabet, Garcia, M; Claverias, Laura; Magret, Monica; Pellicer, Ana, M; Rodriguez, Lucia, L; Sánchez-Ballesteros, Jesús; González-Salamanca, Ángela; Jimenez, Antonio, G; Huerta, Francisco, P; Diaz, Juan, Carlos J Sotillo; Lopez, Esther, Bermejo; Moya, David, D Llinares; Alfonso, Alec, a Tallet; Luis, Palazon, Sanchez Eugenio; Cesar, Palazon, Sanchez; Rafael, Sánchez, I; Virgilio, Corcoles, G; Recio, Noelia, N; Adamsson, Richard, O; Rylander, Christian, C; Holzgraefe, Bernhard; Broman, Lars, M; Wessbergh, Joanna; Persson, Linnea; Schiöler, Fredrik; Kedelv, Hans; Tibblin, Anna, Oscarsson; Appelberg, Henrik; Hedlund, Lars; Helleberg, Johan; Eriksson, Karin, E; Glietsch, Rita; Larsson, Niklas; Nygren, Ingela; Nunes, Silvia, L; Morin, Anna-Karin; Kander, Thomas; Adolfsson, Anne; Zender, Hervé, O; Leemann-Refondini, Corinne; Elatrous, Souheil; Bouchoucha, Slaheddine; Chouchene, Imed; Ouanes, Islem; Souissi, Asma, Ben; Kamoun, Salma; Demirkiran, Oktay; Aker, Mustafa; Erbabacan, Emre; Ceylan, Ilkay; Girgin, Nermin, Kelebek; Ozcelik, Menekse; Ünal, Necmettin; Meco, Basak, Ceyda; Akyol, Onat, O; Derman, Suleyman, S; Kennedy, Barry; Parhar, Ken; Srinivasa, Latha; Mcauley, Danny; Hopkins, Phil; Mellis, Clare; Kakar, Vivek; Hadfield, Dan; Vercueil, Andre; Bhowmick, Kaushik; Humphreys, Sally, K; Ferguson, Andrew; Mckee, Raymond; Raj, Ashok, S; Fawkes, Danielle, A; Watt, Philip; Twohey, Linda; Jha, Rajeev, R; Thomas, Matthew; Morton, Alex; Kadaba, Varsha; Smith, Mark, J; Hormis, Anil, P; Kannan, Santhana, G; Namih, Miriam; Reschreiter, Henrik; Camsooksai, Julie; Kumar, Alek; Rugonfalvi, Szabolcs; Nutt, Christopher; Oneill, Orla; Seasman, Colette; Dempsey, Ged; Scott, Christopher, J; Ellis, Helen, E; Mckechnie, Stuart; Hutton, Paula, J; Di Tomasso, Nora, N; Vitale, Michela, N; Griffin, Ruth, O; Dean, Michael, N; Cranshaw, Julius, H; Willett, Emma, L; Ioannou, Nicholas; Gillis, Sarah; Csabi, Peter; Macfadyen, Rosaleen; Dawson, Heidi; Preez, Pieter, D; Williams, Alexandra, J; Boyd, Owen; de Gordoa, Laura Ortiz-Ruiz; Bramall, Jon; Symmonds, Sophie; Chau, Simon, K; Wenham, Tim; Szakmany, Tamas; Toth-Tarsoly, Piroska; Mccalman, Katie, H; Alexander, Peter; Stephenson, Lorraine; Collyer, Thomas; Chapman, Rhiannon; Cooper, Raphael; Allan, Russell, M; Sim, Malcolm; Wrathall, David, W; Irvine, Donald, A; Zantua, Charing, Kim S; Adams, John, C; Burtenshaw, Andrew, J; Sellors, Gareth, P; Welters, Ingeborg, D; Williams, Karen, E; Hessell, Robert, J; Oldroyd, Matthew, G; Battle, Ceri, E; Pillai, Suresh; Kajtor, Istvan; Sivashanmugavel, Mageswaran; Okane, Sinead, C; Donnelly, Adrian; Frigyik, Aniko, D; Careless, Jon, P; May, Martin, M; Stewart, Richard; Trinder, T, John; Hagan, Samantha, J; Cole, Jade, M; Macfie, Caroline, C; Dowling, Anna, T; Nin, Nicolás; Nuñez, Edgardo; Pittini, Gustavo; Rodriguez, Ruben; Imperio, María, C; Santos, Cristina; França, Ana, G; Ebeid, Alejandro; Deicas, Alberto; Serra, Carolina; Uppalapati, Aditya; Kamel, Ghassan; Bannergoodspeed, Valerie, M; Beitler, Jeremy, R; Mukkera, Satyanarayana, Reddy; Kulkarni, Shreedhar; Shinn Iii, John, O; Gomaa, Dina; Tainter, Christopher; Lee, Jarone; Mesar, Tomaz; Yeatts, Dale, J; Warren, Jessica; Lanspa, Michael, J; Miller, Russel, R; Grissom, Colin, K; Brown, Samuel, M; Bauer, Philippe, R; Gosselin, Ryan, J; Kitch, Barrett, T; Cohen, Jason, E; Beegle, Scott, H; Choudry, Shazia; Gueret, Renaud, M; Tulaimat, Aiman; Stigler, William; Batra, Hitesh; Huff, Nidhi, G; Lamb, Keith, D; Oetting, Trevor, W; Mohr, Nicholas, M; Judy, Claine; Saito, Shigeki; Kheir, Fayez, M; Kheir, Fayez; Schlichting, Adam, B; Delsing, Angela; Crouch, Daniel, R; Elmasri, Mary; Ismail, Dina; Dreyer, Kyle, R; Blakeman, Thomas, C; Baro, Rebecca, M; Hou, Peter, C; Seethala, Raghu; Aisiku, Imo; Henderson, Galen; Frendl, Gyorgy; Hou, Sen-Kuang; Owens, Robert, L; Schomer, Ashley |
| Contributors: |
Centre de recherche en épidémiologie et santé des populations (CESP); Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse; AP-HP. Université Paris Saclay-AP-HP. Université Paris Saclay-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay; Hôpital Bicêtre AP-HP, Le Kremlin-Bicêtre; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP) |
| Source: |
ISSN: 2052-0492 ; Journal of Intensive Care ; https://uvsq.hal.science/hal-03945218 ; Journal of Intensive Care, 2022, 10, ⟨10.1186/s40560-022-00648-x⟩. |
| Publisher Information: |
CCSD; BioMed Central |
| Publication Year: |
2022 |
| Collection: |
Université de Versailles Saint-Quentin-en-Yvelines: HAL-UVSQ |
| Subject Terms: |
Cardiogenic pulmonary edema; Ventilator-induced lung injury; Driving pressure; Mechanical ventilation; Mechanical ventilation Cardiogenic pulmonary edema Ventilator-induced lung injury Driving pressure; [SDV]Life Sciences [q-bio] |
| Description: |
International audience ; Background: Patients with acute respiratory failure caused by cardiogenic pulmonary edema (CPE) may require mechanical ventilation that can cause further lung damage. Our aim was to determine the impact of ventilatory settings on CPE mortality. Methods: Patients from the LUNG SAFE cohort, a multicenter prospective cohort study of patients undergoing mechanical ventilation, were studied. Relationships between ventilatory parameters and outcomes (ICU discharge/ hospital mortality) were assessed using latent mixture analysis and a marginal structural model. Results: From 4499 patients, 391 meeting CPE criteria (median age 70 [interquartile range 59-78], 40% female) were included. ICU and hospital mortality were 34% and 40%, respectively. ICU survivors were younger (67 [57-77] vs 74 [64-80] years, p < 0.001) and had lower driving (12 [8-16] vs 15 [11-17] cmH 2 O, p < 0.001), plateau (20 [15-23] vs 22 [19-26] cmH 2 O, p < 0.001) and peak (21 [17-27] vs 26 [20-32] cmH 2 O, p < 0.001) pressures. Latent mixture analysis of patients receiving invasive mechanical ventilation on ICU day 1 revealed a subgroup ventilated with high pressures with lower probability of being discharged alive from the ICU (hazard ratio [HR] 0.79 [95% confidence interval 0.60-1.05], p = 0.103) and increased hospital mortality (HR 1.65 [1.16-2.36], p = 0.005). In a marginal structural model, driving pressures in the first week (HR 1.12 [1.06-1.18], p < 0.001) and tidal volume after day 7 (HR 0.69 [0.52-0.93], p = 0.015) were related to survival. Conclusions: Higher airway pressures in invasively ventilated patients with CPE are related to mortality. These patients may be exposed to an increased risk of ventilator-induced lung injury. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1186/s40560-022-00648-x |
| Availability: |
https://uvsq.hal.science/hal-03945218; https://uvsq.hal.science/hal-03945218v1/document; https://uvsq.hal.science/hal-03945218v1/file/s40560-022-00648-x.pdf; https://doi.org/10.1186/s40560-022-00648-x |
| Rights: |
http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.201BC657 |
| Database: |
BASE |