T cell memory response to MPXV infection exhibits greater effector function and migratory potential compared to MVA-BN vaccination
| Title: | T cell memory response to MPXV infection exhibits greater effector function and migratory potential compared to MVA-BN vaccination |
|---|---|
| Authors: | Chen, JL; Wang, B; Lu, Y; Antoun, E; Bird, O; Drennan, PG; Yin, Z; Liu, G; Yao, X; Pidoux, M; Bates, A; Jayathilaka, D; Wang, J; Angus, B; Beer, S; Espinosa, A; Kenneth Baillie, J; Semple, MG; Rostron, T; Waugh, C; Sopp, P; Knight, JC; Fullerton, JN; Coles, M; Smith, GL; Mentzer, AJ; Peng, Y; Dong, T; Openshaw, PJM; Alex, B; Andrikopoulos, P; Bach, B; Barclay, WS; Bogaert, D; Chand, M; Chechi, K; Cooke, GS; Filipe, ADS; de Silva, T; Docherty, AB; Correia, GDS; Dumas, ME; Dunning, J; Fletcher, T; Green, CA; Greenhalf, W; Griffin, JL; Gupta, RK; Harrison, EM; Ho, AYW; Holden, K; Horby, PW; Ijaz, S; Khoo, S; Klenerman, P; Law, A; Lewis, MR; Liggi, S; Lim, WS; Maslen, L; Merson, L; Meynert, AM; Moore, SC; Noursadeghi, M; Olanipekun, M; Osagie, A; Palmarini, M; Palmieri, C; Paxton, WA; Pollakis, G; Price, N; Rambaut, A; Robertson, DL; Russell, CD; Sanchoshimizu, V; Sands, CJ; Scott, JT; Sigfrid, L; Solomon, T; Sriskandan, S; Stuart, D; Summers, C; Swann, OV; Takats, Z; Takis, P; Tedder, RS; Roger Thompson, AA; Thomson, EC; Thwaites, RS; Turtle, LCW; Zambon, M; Drake, TM; Fairfield, CJ; Knight, SR; McLean, KA; Murphy, D; Norman, L |
| Publisher Information: | Springer Science and Business Media LLC |
| Publication Year: | 2025 |
| Collection: | The University of Liverpool Repository |
| Description: | In 2022, a global mpox outbreak occurred, and remains a concern today. The T cell memory response to MPXV (monkeypox virus) infection has not been fully investigated. In this study, we evaluate this response in convalescent and MVABN (Modified Vaccinia Ankara-Bavarian Nordic) vaccinated individuals using VACV-infected cells. Strong CD8 + and CD4 + T cell responses are observed, and T cell responses are biased towards viral early expressed proteins. We identify seven immunodominant HLA-A*02:01 restricted MPXV-specific epitopes and focus our detailed phenotypic and scRNAseq analysis on the immunodominant HLA-A*02:01-G5R 18-26 -specific CD8 + T cell response. While tetramer + CD8 + T cells share similar differentiation and activation phenotypes, T cells from convalescent individuals show greater cytotoxicity, migratory potential to site of infection and TCR clonal expansion. Our data suggest that effective functional profiles of MPXV-specific memory T cells induced by Mpox infection may have an implication on the long-term protective responses to future infection. |
| Document Type: | article in journal/newspaper |
| File Description: | application/pdf |
| Language: | English |
| ISSN: | 2041-1723 |
| Relation: | https://livrepository.liverpool.ac.uk/3193727/1/T%20cell%20memory%20response%20to%20MPXV%20infection%20exhibits%20greater%20effector%20function%20and%20migratory%20potential%20compared%20to%20MVA-BN%20vacci.pdf; Collapse authors list. Chen, JL, Wang, B orcid:0000-0002-3746-0188 , Lu, Y orcid:0000-0003-4701-5560 , Antoun, E, Bird, O orcid:0000-0002-4917-500X , Drennan, PG, Yin, Z, Liu, G, Yao, X, Pidoux, M et al (show 89 more authors) , Bates, A orcid:0000-0003-4241-2807 , Jayathilaka, D, Wang, J, Angus, B orcid:0000-0003-3598-7784 , Beer, S orcid:0000-0002-0988-3458 , Espinosa, A, Kenneth Baillie, J orcid:0000-0001-5258-793X , Semple, MG orcid:0000-0001-9700-0418 , Rostron, T, Waugh, C, Sopp, P, Knight, JC orcid:0000-0002-0377-5536 , Fullerton, JN orcid:0000-0002-4855-9255 , Coles, M orcid:0000-0001-8079-9358 , Smith, GL orcid:0000-0002-3730-9955 , Mentzer, AJ orcid:0000-0002-4502-2209 , Peng, Y, Dong, T orcid:0000-0003-3545-3758 , Openshaw, PJM, Semple, MG orcid:0000-0001-9700-0418 , Alex, B, Andrikopoulos, P, Bach, B, Barclay, WS, Bogaert, D, Chand, M, Chechi, K, Cooke, GS, Filipe, ADS, de Silva, T, Docherty, AB, Correia, GDS, Dumas, ME, Dunning, J, Fletcher, T, Green, CA, Greenhalf, W orcid:0000-0002-1865-3195 , Griffin, JL, Gupta, RK, Harrison, EM, Ho, AYW, Holden, K, Horby, PW, Ijaz, S, Khoo, S, Klenerman, P, Law, A, Lewis, MR, Liggi, S, Lim, WS, Maslen, L, Mentzer, AJ, Merson, L, Meynert, AM, Moore, SC, Noursadeghi, M, Olanipekun, M, Osagie, A, Palmarini, M, Palmieri, C, Paxton, WA orcid:0000-0001-5200-0801 , Pollakis, G orcid:0000-0002-9659-5461 , Price, N, Rambaut, A, Robertson, DL, Russell, CD, Sanchoshimizu, V, Sands, CJ, Scott, JT, Sigfrid, L, Solomon, T orcid:0000-0001-7266-6547 , Sriskandan, S, Stuart, D, Summers, C, Swann, OV, Takats, Z, Takis, P, Tedder, RS, Roger Thompson, AA, Thomson, EC, Thwaites, RS, Turtle, LCW, Zambon, M, Drake, TM, Fairfield, CJ, Knight, SR, McLean, KA, Murphy, D and Norman, L (2025) T cell memory response to MPXV infection exhibits greater effector function and migratory potential compared to MVA-BN vaccination Nature Communications, 16 (1). 4362-. ISSN 2041-1723, 2041-1723 |
| DOI: | 10.1038/s41467-025-59370-5 |
| Availability: | https://livrepository.liverpool.ac.uk/3193727/; https://doi.org/10.1038/s41467-025-59370-5 |
| Rights: | cc_by_4 |
| Accession Number: | edsbas.205C4FE5 |
| Database: | BASE |