| Title: |
Common and Divergent Features of Galactose-1-phosphate and Fructose-1-phosphate Toxicity in Yeast |
| Authors: |
Gibney, Patrick A; Schieler, Ariel; Chen, Jonathan C; Bacha-Hummel, Jessie M; Botstein, Maxim; Volpe, Matthew; Silverman, Sanford J; Xu, Yifan; Bennett, Bryson D; Rabinowitz, Joshua D; Botstein, David |
| Contributors: |
Drubin, David G |
| Source: |
Molecular Biology of the Cell, vol 29, iss 8 |
| Publisher Information: |
eScholarship, University of California |
| Publication Year: |
2018 |
| Collection: |
University of California: eScholarship |
| Subject Terms: |
3101 Biochemistry and Cell Biology (for-2020); 31 Biological Sciences (for-2020); Culture Media (mesh); Fructosephosphates (mesh); Galactosephosphates (mesh); Gene Expression Regulation; Fungal (mesh); Genes; Suppressor (mesh); Mutation (mesh); Saccharomyces cerevisiae (mesh); 06 Biological Sciences (for); 11 Medical and Health Sciences (for); Developmental Biology (science-metrix) |
| Subject Geographic: |
mbc.e17-11-0666 |
| Description: |
Metabolic dysregulation leading to sugar-phosphate accumulation is toxic in organisms ranging from bacteria to humans. By comparing two models of sugar-phosphate toxicity in Saccharomyces cerevisiae, we demonstrate that toxicity occurs, at least in part, through multiple, isomer-specific mechanisms, rather than a single general mechanism. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
qt3xg6n2c9; https://escholarship.org/uc/item/3xg6n2c9; https://escholarship.org/content/qt3xg6n2c9/qt3xg6n2c9.pdf |
| DOI: |
10.1091/mbc.e17-11-0666 |
| Availability: |
https://escholarship.org/uc/item/3xg6n2c9; https://escholarship.org/content/qt3xg6n2c9/qt3xg6n2c9.pdf; https://doi.org/10.1091/mbc.e17-11-0666 |
| Rights: |
CC-BY-NC-SA |
| Accession Number: |
edsbas.2060DF57 |
| Database: |
BASE |