| Title: |
Shorter androgen receptor polyQ alleles protect against life-threatening COVID-19 disease in European males |
| Authors: |
Baldassarri, Margherita; Gut, Marta; GEN-COVID Multicenter Study |
| Publisher Information: |
Elsevier |
| Publication Year: |
2021 |
| Collection: |
UPF Digital Repository (Universitat Pompeu Fabra, Barcelona) |
| Subject Terms: |
COVID-19 (Malaltia); Homes -- Malalties |
| Description: |
Background: While SARS-CoV-2 similarly infects men and women, COVID-19 outcome is less favorable in men. Variability in COVID-19 severity may be explained by differences in the host genome. Methods: We compared poly-amino acids variability from WES data in severely affected COVID-19 patients versus SARS-CoV-2 PCR-positive oligo-asymptomatic subjects. Findings: Shorter polyQ alleles (≤22) in the androgen receptor (AR) conferred protection against severe outcome in COVID-19 in the first tested cohort (both males and females) of 638 Italian subjects. The association between long polyQ alleles (≥23) and severe clinical outcome (p = 0.024) was also validated in an independent cohort of Spanish men |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
http://hdl.handle.net/10230/53029; http://dx.doi.org/10.1016/j.ebiom.2021.103246 |
| DOI: |
10.1016/j.ebiom.2021.103246 |
| Availability: |
http://hdl.handle.net/10230/53029; https://doi.org/10.1016/j.ebiom.2021.103246 |
| Rights: |
© Margherita Baldassarri et al. 2021. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) ; http://creativecommons.org/licenses/by-nc-nd/4.0/ ; info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.2080E511 |
| Database: |
BASE |