| Title: |
Comparison of the Right Atrial Expansion Index with Inferior Vena Cava Assessment for Echocardiographic Estimation of the Right Atrial Pressure |
| Authors: |
Genovese D.; Previtero M.; Prete G.; Strosio M.; Cernetti C.; Badano L. P.; Muraru D.; Palermo C.; Tarantini G.; Perazzolo Marra M. |
| Contributors: |
Genovese, D; Previtero, M; Prete, G; Strosio, M; Cernetti, C; Badano, L; Muraru, D; Palermo, C; Tarantini, G; Perazzolo Marra, M |
| Publisher Information: |
Elsevier Inc.; US |
| Publication Year: |
2026 |
| Collection: |
Università degli Studi di Milano-Bicocca: BOA (Bicocca Open Archive) |
| Subject Terms: |
Central venous pressure; Echocardiography; Right atrial compliance; Right atrial pressure; Right atrial reservoir function; Settore MEDS-07/B - Malattie dell'apparato cardiovascolare |
| Description: |
Background: Evaluating right atrial pressure (RAP) is essential for managing cardiac diseases. Right heart catheterization (RHC) measures RAP directly but is invasive. In contrast, transthoracic echocardiography (TTE) provides a noninvasive estimate of RAP through inferior vena cava (IVC) assessment despite some limitations. The right atrial expansion index (RAEI) reflects right atrial compliance by measuring the relative increase in volume during the reservoir phase. This study aimed to validate RAEI as a noninvasive parameter for estimating RAP. Methods: We retrospectively enrolled 1,020 patients (728 in the derivation and 292 in the validation cohort) with various chronic cardiac diseases who underwent clinically indicated RHC and TTE within 24 hours. Right atrial pressure was measured during the RHC and defined as elevated when above 10 mm Hg. Right atrial expansion index and other TTE parameters were measured offline and blinded to RHC results. Results: In the derivation cohort, RAEI showed a logarithmic correlation with RAP (lnRAEI-RAP: r = −0.65, P < .001). The natural log of RAEI was an independent and additive predictor of RAP, outperforming clinical, hemodynamic, and echocardiographic parameters, including IVC assessment. The natural log of RAEI was more accurate than IVC assessment for identifying RAP ≥10 mm Hg (area under the curve lnRAEI, 0.840,;P < .001; optimal cutoff, lnRAEI |
| Document Type: |
article in journal/newspaper |
| File Description: |
STAMPA |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/40967280; info:eu-repo/semantics/altIdentifier/wos/WOS:001684828800001; volume:39; issue:2; firstpage:167; lastpage:178; numberofpages:12; journal:JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY; https://hdl.handle.net/10281/572565 |
| DOI: |
10.1016/j.echo.2025.09.005 |
| Availability: |
https://hdl.handle.net/10281/572565; https://doi.org/10.1016/j.echo.2025.09.005 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Creative Commons ; license uri:http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.20C58635 |
| Database: |
BASE |