| Title: |
Synthesis and anti-parasitic activity of C-benzylated (N-arylcarbamoyl) alkylphosphonate esters |
| Authors: |
Adeyemi, Christiana Modupe; Isaacs, Michelle; Mnkandhla, Dumisani; Krause, Rui W M; Klein, Rosalyn; Hoppe, Heinrich C; Lobb, Kevin A; Kaye, Perry T |
| Publication Year: |
2017 |
| Collection: |
SEALS Digital Commons (South East Academic Libraries System, South Africa) |
| Description: |
Unexpected substituent-dependent regioselectivty challenges in the synthesis of C-benzylated (N-arylcarbamoyl)phosphonate esters have been resolved. The C-benzylated N-furfurylcarbamoyl derivative showed low micromolar PfLDH inhibition, while one of the C-benzylated N-arylcarbamoyl analogues was active against Nagana Trypanosoma brucei parasites which are responsible for African trypanosomiasis in cattle. |
| Document Type: |
article in journal/newspaper |
| File Description: |
7 pages; pdf |
| Language: |
English |
| Relation: |
Tetrahedron; https://hdl.handle.net/10962/125641; vital:35803; http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:35803; https://doi.org/10.1016/j.tet.2017.01.045 |
| DOI: |
10.1016/j.tet.2017.01.045 |
| Availability: |
https://hdl.handle.net/10962/125641; http://vital.seals.ac.za:8080/vital/access/manager/Repository/vital:35803; https://doi.org/10.1016/j.tet.2017.01.045 |
| Rights: |
Tetrahedron ; Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions) |
| Accession Number: |
edsbas.20C72299 |
| Database: |
BASE |