| Title: |
Stroke Treatment Academic Industry Roundtable |
| Authors: |
Saver, Jeffrey L; Jovin, Tudor G; Smith, Wade S; Albers, Gregory W; members, STAIR VIII writing committee; Baron, Jean-Claude; Boltze, Johannes; Broderick, Joseph P; Davis, Lisa A; Demchuk, Andrew M; DeSena, Salvatore; Fiehler, Jens; Gorelick, Philip B; Hacke, Werner; Holt, Bill; Jahan, Reza; Jing, Hui; Khatri, Pooja; Kidwell, Chelsea S; Lees, Kennedy R; Lev, Michael H; Liebeskind, David S; Luby, Marie; Lyden, Patrick; Megerian, J Thomas; Mocco, J; Muir, Keith W; Rowley, Howard A; Ruedy, Richard M; Savitz, Sean I; Sipelis, Vitas J; Shimp, Samuel K; Wechsler, Lawrence R; Wintermark, Max; Wu, Ona; Yavagal, Dileep R; Yoo, Albert J |
| Source: |
Stroke, vol 44, iss 12 |
| Publisher Information: |
eScholarship, University of California |
| Publication Year: |
2013 |
| Collection: |
University of California: eScholarship |
| Subject Terms: |
32 Biomedical and Clinical Sciences (for-2020); 3211 Oncology and Carcinogenesis (for-2020); Brain Disorders (rcdc); Clinical Trials and Supportive Activities (rcdc); Neurosciences (rcdc); Stroke (rcdc); Cerebrovascular (rcdc); Clinical Research (rcdc); Biomedical Imaging (rcdc); Brain Ischemia (mesh); Clinical Trials as Topic (mesh); Fibrinolytic Agents (mesh); Humans (mesh); Research Design (mesh); Stroke (mesh); Thrombectomy (mesh); Thrombolytic Therapy (mesh); endovascular recanalization; ischemic; reperfusion; stroke; STAIR VIII Consortium; 1102 Cardiorespiratory Medicine and Haematology (for); 1103 Clinical Sciences (for); 1109 Neurosciences (for); Neurology & Neurosurgery (science-metrix); 3202 Clinical sciences (for-2020); 3209 Neurosciences (for-2020); 4201 Allied health and rehabilitation science (for-2020) |
| Time: |
3596 - 3601 |
| Description: |
BACKGROUND AND PURPOSE: The goal of the Stroke Treatment Academic Industry Roundtable (STAIR) meetings is to advance the development of stroke therapies. At STAIR VIII, consensus recommendations were developed for clinical trial strategies to demonstrate the benefit of endovascular reperfusion therapies for acute ischemic stroke. SUMMARY OF REVIEW: Prospects for success with forthcoming endovascular trials are robust, because new neurothrombectomy devices have superior reperfusion efficacy compared with earlier-generation interventions. Specific recommendations are provided for trial designs in 3 populations: (1) patients undergoing intravenous fibrinolysis, (2) early patients ineligible for or having failed intravenous fibrinolysis, and (3) wake-up and other late-presenting patients. Among intravenous fibrinolysis-eligible patients, key principles are that CT or MRI confirmation of target arterial occlusions should precede randomization; endovascular intervention should be pursued with the greatest rapidity possible; and combined intravenous and neurothrombectomy therapy is more promising than neurothrombectomy alone. Among patients ineligible for or having failed intravenous fibrinolysis, scientific equipoise was affirmed and the need to randomize all eligible patients emphasized. Vessel imaging to confirm occlusion is mandatory, and infarct core and penumbral imaging is desirable in later time windows. Additional STAIR VIII recommendations include approaches to test multiple devices in a single trial, utility weighting of disability end points, and adaptive designs to delineate time and tissue injury thresholds at which benefits from intervention no longer accrue. CONCLUSIONS: Endovascular research priorities in acute ischemic stroke are to perform trials testing new, highly effective neuro thrombectomy devices rapidly deployed in patients confirmed to have target vessel occlusions. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
qt60g9c5s9; https://escholarship.org/uc/item/60g9c5s9; https://escholarship.org/content/qt60g9c5s9/qt60g9c5s9.pdf |
| DOI: |
10.1161/strokeaha.113.002769 |
| Availability: |
https://escholarship.org/uc/item/60g9c5s9; https://escholarship.org/content/qt60g9c5s9/qt60g9c5s9.pdf; https://doi.org/10.1161/strokeaha.113.002769 |
| Rights: |
public |
| Accession Number: |
edsbas.20D3A1F5 |
| Database: |
BASE |