| Title: |
Recruitment and Expansion of Tregs Cells in the Tumor Environment—How to Target Them? |
| Authors: |
Justine Cinier; Margaux Hubert; Laurie Besson; Anthony Di Roio; Céline Rodriguez; Vincent Lombardi; Christophe Caux; Christine Ménétrier-Caux |
| Source: |
Cancers, Vol 13, Iss 1850, p 1850 (2021) |
| Publisher Information: |
MDPI AG |
| Publication Year: |
2021 |
| Collection: |
Directory of Open Access Journals: DOAJ Articles |
| Subject Terms: |
regulatory T cells; tumor microenvironment; recruitment; proliferation; stability; therapeutic targeting; Neoplasms. Tumors. Oncology. Including cancer and carcinogens; RC254-282 |
| Description: |
Regulatory T cells (Tregs) are present in a large majority of solid tumors and are mainly associated with a poor prognosis, as their major function is to inhibit the antitumor immune response contributing to immunosuppression. In this review, we will investigate the mechanisms involved in the recruitment, amplification and stability of Tregs in the tumor microenvironment (TME). We will also review the strategies currently developed to inhibit Tregs’ deleterious impact in the TME by either inhibiting their recruitment, blocking their expansion, favoring their plastic transformation into other CD4 + T-cell subsets, blocking their suppressive function or depleting them specifically in the TME to avoid severe deleterious effects associated with Treg neutralization/depletion in the periphery and normal tissues. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://www.mdpi.com/2072-6694/13/8/1850; https://doaj.org/toc/2072-6694; https://doaj.org/article/20d5d55235b94dcc95456e92ec491f46 |
| DOI: |
10.3390/cancers13081850 |
| Availability: |
https://doi.org/10.3390/cancers13081850; https://doaj.org/article/20d5d55235b94dcc95456e92ec491f46 |
| Accession Number: |
edsbas.214CC920 |
| Database: |
BASE |