| Title: |
Impact of Menstrual Cycle and Oral Contraceptives on Haematological and Inflammatory Biomarkers in Highly Trained Female Athletes |
| Authors: |
Collomp, Katia; Teulier, Caroline; Castanier, Carole; Bonnigal, Juliette; Marchand, Alexandre; Buisson, Corinne; Ericsson, Magnus; Crépin, Nathalie; Duron, Emmanuelle; Favory, Eric; Zimmermann, Mathieu; Amiot, Virgile; Olivier, Agnès |
| Contributors: |
Complexité, Innovation, Activités Motrices et Sportives (CIAMS); Université d'Orléans (UO)-Université Paris-Saclay; Laboratoire AntiDopage Français (LADF); Université Paris-Saclay; Institut Français du Cheval et de l'Equitation Saumur (IFCE); Hôpital Paul Brousse; AP-HP. Université Paris Saclay; Centre Hospitalier Universitaire d'Orléans (CHU Orléans); This project was carried out with the support of the World Anti-Doping Agency (WADA) (Grant Number 22D05KC) and the Institut Français du Cheval et de l'Equitation (IFCE). |
| Source: |
ISSN: 1942-7603. |
| Publisher Information: |
CCSD; John Wiley |
| Publication Year: |
2025 |
| Subject Terms: |
contraception; elite female athletes; hormonal status; reticulocytes; transferrin; [SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics |
| Description: |
International audience ; Haematological and inflammatory biomarkers play an important role in athlete performance and health, with some of them used in the fight against doping. However, little is known about how they are modulated by sex hormone fluctuations in highly trained female athletes. We therefore measured the haematological parameters monitored in the athlete biological passport (ABP) as well as erythropoietin, serum markers of iron and inflammatory statuses (iron, ferritin, transferrin, transferrin saturation, albumin, creatinine, total protein, interleukin‐6 and TNF‐alpha) in 20 highly trained female athletes: 10 with normal menstrual cycle (NMC) during the early follicular and mid‐luteal phases and 10 using a combined oral contraceptive (COC, i.e., ethinyloestradiol and levonorgestrel) during active and inactive hormone intake. Body composition, leptin and lipid profile (total cholesterol, HDL, LDL and triglycerides) were determined in parallel. No changes were observed throughout NMC phases. Irrespective of active/inactive pill intake, COC use increased transferrin, triglycerides as well as reticulocyte count ( p < 0.05) and decreased interleukin‐6 ( p < 0.05), with no significant changes in the other parameters studied. In conclusion, given our results across NMC phases in highly trained athletes, it seems warranted to investigate whether intense physical training would mitigate the impact of endogenous sex hormones on body composition and haematological and inflammatory parameters. In addition, further studies are needed to determine the extent of the changes induced by COCs on these blood biomarkers in elite female athletes when subjected to extreme environments such as intensive training or competition in humid heat, cold and/or hypoxia or when using other medications in parallel. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/39911023; PUBMED: 39911023; PUBMEDCENTRAL: PMC12401630 |
| DOI: |
10.1002/dta.3859 |
| Availability: |
https://hal.science/hal-04936830; https://hal.science/hal-04936830v1/document; https://hal.science/hal-04936830v1/file/Drug%20Testing%20and%20Analysis%20-%202025%20-%20Collomp%20-%20Impact%20of%20Menstrual%20Cycle%20and%20Oral%20Contraceptives%20on%20Haematological%20and.pdf; https://doi.org/10.1002/dta.3859 |
| Rights: |
https://creativecommons.org/licenses/by-nc-nd/4.0/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.2224DC7 |
| Database: |
BASE |