| Title: |
DIPG-25. Patterns of cerebrospinal fluid diversion and survival in children with diffuse intrinsic pontine glioma: a report from the International Diffuse Intrinsic Pontine Glioma Registry |
| Authors: |
Cooney, Tabitha; DeWire-Schottmiller, Mariko; Lane, Adam; Saab, Raya; Bandopadhayay, Pratiti; Dorris, Kathleen; Packer, Roger; Kilburn, Lindsay; Minturn, Jane; Dodgshun, Andrew; Parkin, Sara; Goldman, Stewart; Sandler, Eric; Greiner, Robert; Gottardo, Nicholas; Dholaria, Hetal; Coven, Scott; Hassall, Tim; Hansford, Jordan; Samson, Yvan; Leary, Sarah; Bartels, Ute; Fonseca, Adriana; Bouffet, Eric; Tinkle, Christopher; Monje, Michelle; Fisher, Paul; Ziegler, David; Chintagumpala, Murali; Wagner, Lars; Koschmann, Carl; Leach, James; Jones, Blaise; Benito, Elisa Carrasquedo; Bond, Hailey; Chaney, Brooklyn; Black, Katie; Asher, Anthony; Fouladi, Maryam; Hoffman, Lindsey; Warren, Katherine |
| Source: |
Neuro-Oncology ; volume 24, issue Supplement_1, page i23-i24 ; ISSN 1522-8517 1523-5866 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2022 |
| Description: |
BACKGROUND: There are no standard practice guidelines for cerebrospinal (CSF) diversion for diffuse intrinsic pontine glioma (DIPG), nor clear understanding of potential for palliation and life-prolongation. We evaluated CSF diversion characteristics in children with DIPG to determine incidence, indications, symptom effects, and survival. METHODS: Data were extracted from subjects registered in the International DIPG registry (IDIPGR). Univariable analyses was performed using the Fisher’s exact test or Wilcoxon rank sum test. Survival was estimated using the Kaplan-Meier method. RESULTS: Evaluable patients (n=542) met criteria for DIPG diagnosis by central radiologic review; of those, 126 (23%) had permanent CSF diversion. Median time from diagnosis to diversion was 0.5 months (IQR 0.1-4.5 months). Those with permanent diversion were significantly younger (median 5.4 years vs 7.0 years, p |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1093/neuonc/noac079.082 |
| Availability: |
https://doi.org/10.1093/neuonc/noac079.082; https://academic.oup.com/neuro-oncology/article-pdf/24/Supplement_1/i23/43945033/noac079.082.pdf |
| Rights: |
https://creativecommons.org/licenses/by-nc/4.0/ |
| Accession Number: |
edsbas.22853F9F |
| Database: |
BASE |