| Title: |
Tumor index predicts recurrences of patients with pathological stage Ⅰ gastric cancer after radical surgical resection |
| Authors: |
Yijia Lin; Huaxian Chen; Chengzhi Wei; Dandong Luo; Jianping Guo; Xiansheng Hu; Yinghan Chen; Junsheng Peng; Yongming Chen; Lei Lian |
| Source: |
BMC Cancer, Vol 25, Iss 1, Pp 1-7 (2025) |
| Publisher Information: |
BMC |
| Publication Year: |
2025 |
| Collection: |
Directory of Open Access Journals: DOAJ Articles |
| Subject Terms: |
Stage ⅰ gastric cancer; Tumor index; Prognosis; Recurrence; Neoplasms. Tumors. Oncology. Including cancer and carcinogens; RC254-282 |
| Description: |
Background Despite the favorable prognosis of patients with pathological stage I gastric cancer (GC), recurrence may occur in a subset of individuals, and the underlying risk factors are currently being investigated. Tumor index (TI) plays a valuable role in predicting the prognosis of GC. The study aimed to determine the prognostic effect of TI on stage Ⅰ GC. Methods Patients with stage Ⅰ GC who underwent radical resection were enrolled from the two medical centers from 2010 to 2020. TI was calculated by the pathological T stage multiplied by the maximum tumor diameter. The primary outcome was disease-free survival (DFS) and overall survival (OS). Cox regression analyses were utilized to evaluate the correlation between TI and prognosis. Results The final analysis included a total of 684 patients from two medical centers. Higher TI exhibited a significant correlation with several clinicopathologic features, including N0 stage, TNM stage ⅠB, and positive PNI (all P < 0.05). Patients with high TI showed inferior DFS and OS compared to those with a low TI (P < 0.05). Multivariate analysis revealed that TI was an independent prognostic factor for DFS (hazard ratio (HR) = 2.44, P = 0.010) and OS (HR = 2.39, P = 0.014) in patients with stage Ⅰ GC who underwent radical resection. Conclusion TI was an independent risk factor in recurrence and overall survival for stage Ⅰ GC patients who received curative gastrectomy. Incorporation of TI into clinical decision-making regarding adjuvant therapy and intensity of follow-up may be warranted. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://doi.org/10.1186/s12885-025-15157-x; https://doaj.org/toc/1471-2407; https://doaj.org/article/311a099fb5684cf3bdb3d6e9d71490b4 |
| DOI: |
10.1186/s12885-025-15157-x |
| Availability: |
https://doi.org/10.1186/s12885-025-15157-x; https://doaj.org/article/311a099fb5684cf3bdb3d6e9d71490b4 |
| Accession Number: |
edsbas.228F30FF |
| Database: |
BASE |