| Title: |
The effects of age on associations between markers of HIV progression and markers of metabolic function including albumin, haemoglobin and lipid concentrations |
| Authors: |
Samuel, M.; Jose, S.; Winston, A.; Nelson, M.; Johnson, M.; Chadwick, D.; Fisher, M.; Leen, C.; Gompels, M.; Gilson, R.; Post, Frank; Hay, P.; Sabin, C. A.; Ainsworth, Jonathan; Anderson, Jane; Babiker, Abdel; Chadwick, David; Delpech, Valerie; Fisher, Martin; Gazzard, Brian; Gilson, Richard; Gompels, Mark; Hay, Phillip; Johnson, Margaret; Kegg, Stephen; Leen, Clifford; Nelson, Mark; Orkin, Chloe; Palfreeman, Adrian; Pillay, Deenan; Sachikonye, Memory |
| Publisher Information: |
Wiley-Blackwell Publishing |
| Publication Year: |
2014 |
| Collection: |
The University of Queensland: UQ eSpace |
| Subject Terms: |
Ageing; Albumin; Haemoglobin; HIV; Lipid metabolism; 2719 Health Policy; 2725 Infectious Diseases; 2736 Pharmacology (medical) |
| Description: |
Objectives: We investigated whether age modified associations between markers of HIV progression, CD4 T lymphocyte count and HIV RNA viral load (VL), and the following markers of metabolic function: albumin, haemoglobin, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC). Methods: A retrospective analysis of data from the United Kingdom Collaborative HIV Cohort was carried out. Analyses were limited to antiretroviral-naïve subjects to focus on the impact of HIV disease itself. A total of 16670 subjects were included in the analysis. Multilevel linear regression models assessed associations between CD4 count/VL and each of the outcomes. Statistical tests for interactions assessed whether associations differed among age groups. Results: After adjustment for gender and ethnicity, there was evidence that lower CD4 count and higher VL were associated with lower TC, LDL-C, haemoglobin and albumin concentrations but higher triglyceride concentrations. Age modified associations between CD4 count and albumin (P |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
1468-1293; 1464-2662 |
| Availability: |
https://espace.library.uq.edu.au/view/UQ:337695b |
| Accession Number: |
edsbas.236028E3 |
| Database: |
BASE |