| Title: |
Palmitoylethanolamide and polydatin in pediatric irritable bowel syndrome: A multicentric randomized controlled trial |
| Authors: |
Nardo G. D.; Bernardo L.; Cremon C.; Barbara G.; Felici E.; Evangelisti M.; Ferretti A.; Furio S.; Piccirillo M.; Coluzzi F.; Parisi P.; Mauro A.; Mari C. D.; D'Angelo F.; Mennini M. |
| Contributors: |
Nardo, G. D.; Bernardo, L.; Cremon, C.; Barbara, G.; Felici, E.; Evangelisti, M.; Ferretti, A.; Furio, S.; Piccirillo, M.; Coluzzi, F.; Parisi, P.; Mauro, A.; Mari, C. D.; D'Angelo, F.; Mennini, M. |
| Publication Year: |
2024 |
| Collection: |
IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) |
| Subject Terms: |
Abdominal pain; Irritable bowel syndrome; Palmitoylethanolamide; Pediatric patient; Placebo |
| Description: |
Objective: This study aimed to evaluate the efficacy and safety of co-micronized palmitoylethanolamide (PEA)/polydatin (PD) in the treatment of abdominal pain symptoms in pediatric patients with irritable bowel syndrome (IBS). Methods: This was a multicenter trial conducted at three Italian pediatric gastroenterology centers, employing a double-blind, placebo-controlled, parallel-arm design. Participants were ages 10 to 17 y and met Rome IV criteria for pediatric IBS. They were randomly allocated to receive either co-micronized PEA/PD or placebo, administered three times daily in a 1:1 ratio, over a 12-wk period. The study assessed baseline severity using the IBS-Severity Scoring System (IBS-SSS) at enrollment and after 4, 8, and 12 wk of treatment. Abdominal pain frequency was assessed on a scale from 1 to 7 d/wk, while stool consistency was classified using the Bristol Stool Scale (BSS) to categorize various IBS subtypes. The primary outcome was the percentage of patients who achieved complete remission, defined as IBS-SSS score |
| Document Type: |
article in journal/newspaper |
| File Description: |
ELETTRONICO |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/38479039; info:eu-repo/semantics/altIdentifier/wos/WOS:001222291200001; volume:122; firstpage:1; lastpage:6; numberofpages:6; journal:NUTRITION; https://hdl.handle.net/11585/1003266; https://www.sciencedirect.com/science/article/pii/S0899900724000479?via=ihub |
| DOI: |
10.1016/j.nut.2024.112397 |
| Availability: |
https://hdl.handle.net/11585/1003266; https://doi.org/10.1016/j.nut.2024.112397; https://www.sciencedirect.com/science/article/pii/S0899900724000479?via=ihub |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.237945C9 |
| Database: |
BASE |