| Title: |
Serum Bile Acids as Markers of Juvenile Liver Disease in α 1 ‐Antitrypsin Deficiency |
| Authors: |
Nemeth, Antal; Samuelson, Kickan; Strandvik, Birgitta |
| Source: |
Journal of Pediatric Gastroenterology and Nutrition ; volume 1, issue 4, page 479-484 ; ISSN 0277-2116 1536-4801 |
| Publisher Information: |
Wiley |
| Publication Year: |
1982 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
Summary Serum bile acids were studied in 34 patients, aged 7/12 to 20 years, with α 1 ‐antitrypsin deficiency. Of these patients, 27 were of Pi‐phenotype Z and 7 of SZ. Liver biopsy according to Menghini was performed in 19 patients. Fasting serum levels of cholic and chenodeoxycholic acids, determined by radioimmunoassay, were compared to conventional liver function tests and liver morphology. All patients with morphological liver cirrhosis had increased fasting levels of serum bile acids. The other patients, including those with severe fibrosis, had normal values. Although standard liver function tests were more pathological in the cirrhotic patients than in the others, serum fasting bile acids seemed to be the most distinct markers of severe liver disease. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1002/j.1536-4801.1982.tb08375.x |
| Availability: |
http://dx.doi.org/10.1002/j.1536-4801.1982.tb08375.x; https://onlinelibrary.wiley.com/doi/pdf/10.1002/j.1536-4801.1982.tb08375.x |
| Rights: |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
| Accession Number: |
edsbas.237EB868 |
| Database: |
BASE |