| Title: |
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape:A Large-Scale Genome-Wide Interaction Study |
| Authors: |
Winkler,Thomas W.; Justice,Anne E.; Graff,Mariaelisa; Barata,Llilda; Feitosa,Mary F.; Chu,Su; Czajkowski,Jacek; Esko,Tonu; Fall,Tove; Kilpelainen,Tuomas O.; Lu,Yingchang; Magi,Reedik; Mihailov,Evelin; Pers,Tune H.; Rueeger,Sina; Teumer,Alexander; Ehret,Georg B.; Ferreira,Teresa; Heard-Costa,Nancy L.; Karjalainen,Juha; Lagou,Vasiliki; Mahajan,Anubha; Neinast,Michael D.; Prokopenko,Inga; Simino,Jeannette; Teslovich,Tanya M.; Jansen,Rick; Westra,Harm-Jan; White,Charles C.; Absher,Devin; Ahluwalia,Tarunveer S.; Ahmad,Shafqat; Albrecht,Eva; Alves,Alexessander Couto; Bragg-Gresham,Jennifer L.; de Craen,Anton J. M.; Bis,Joshua C.; Bonnefond,Amelie; Boucher,Gabrielle; Cadby,Gemma; Cheng,Yu-Ching; Chiang,Charleston W. K.; Haitjema, Saskia; van der Laan, Sander W.; van Setten, Jessica; Asselbergs, Folkert W.; de Bakker, Paul I. W.; Moll, Frans L.; Pasterkamp, Gerard; den Ruijter, Hester M.; CHARGE Consortium; DIAGRAM Consortium; GLGC Consortium; Global-BPGen Consortium; ICBP Consortium; MAGIC Consortium; Circulatory Health; Experimentele Afd. Cardiologie 1; Cardiologie; JC onderzoeksprogramma Methodology; Cancer; Zorgeenheid Vaatchirurgie Medisch; Onderzoek Vrouw Hart & Vaatziekten |
| Publication Year: |
2015 |
| Subject Terms: |
SELF-REPORTED HEIGHT; FAT DISTRIBUTION; MASS INDEX; LIFE-COURSE; BIOLOGICAL PATHWAYS; NATURAL MENOPAUSE; PERIPHERAL-BLOOD; WEIGHT-GAIN; COMMON SNPS; LOCI |
| Description: |
Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age-and/or sex-specific effects of genetic variants on BMI and WHRadjBMI, we performed meta-analyses of 114 studies (up to 320,485 individuals of European descent) with genome-wide chip and/or Metabochip data by the Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Each study tested the association of up to similar to 2.8M SNPs with BMI and WHRadjBMI in four strata (men 50y, women 50y) and summary statistics were combined in stratum-specific meta-analyses. We then screened for variants that showed age-specific effects (G x AGE), sex-specific effects (G x SEX) or age-specific effects that differed between men and women (G x AGE x SEX). For BMI, we identified 15 loci (11 previously established for main effects, four novel) that showed significant (FDR |
| Document Type: |
article in journal/newspaper |
| File Description: |
text/plain |
| Language: |
English |
| ISSN: |
1553-7404 |
| Relation: |
https://dspace.library.uu.nl/handle/1874/332663 |
| Availability: |
https://dspace.library.uu.nl/handle/1874/332663 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.23B640F |
| Database: |
BASE |