| Title: |
Efficacy of rifaximin among non-constipated irritable bowel syndrome patients with or without small intestinal bacterial overgrowth: a randomized, double-blind, placebo-controlled trial |
| Authors: |
Podder, Subrata; Masudur Rahman, M.; Hossain, Mohammad Iqbal; Datta, Raj; Alam, Jane; Golam Kibria, M. |
| Source: |
International Journal of Research in Medical Sciences; Vol. 12 No. 4 (2024): April 2024; 1056-1064 ; 2320-6012 ; 2320-6071 |
| Publisher Information: |
Medip Academy |
| Publication Year: |
2024 |
| Subject Terms: |
Irritable bowel syndrome; Rifaximin; Gastrointestinal disorder; Dysbiosis; Antibiotic therapy |
| Description: |
Background: IBS is a functional gastrointestinal disorder marked by abdominal pain and changes in stool frequency or form. Recent studies indicate a link between IBS, especially the diarrhea-predominant subtype, and small intestinal bacterial overgrowth. This study aimed to evaluate symptom resolution among IBS patients with or without SIBO on rifaximin treatment as compared with placebo. Methods: A double-blind, placebo-controlled, randomized clinical trial took place at the Department of Gastroenterology, Dhaka Medical College and Hospital, from January to December 2019. In the study 104 non-constipated IBS patients were assessed for SIBO using gut aspirate culture. Those with SIBO (≥105 CFU/ml) and those without were randomly assigned (computer-generated) to receive either 1500 mg/day of rifaximin for 14 days or a placebo. Results: Among 104 non-constipated IBS patients, 39% had SIBO, with IBS-D patients more associated (83% vs. 60%). Rifaximin significantly improved symptoms in the SIBO group at 4 and 16 weeks (90% vs. 20%, p |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://www.msjonline.org/index.php/ijrms/article/view/13175/8532; https://www.msjonline.org/index.php/ijrms/article/view/13175 |
| DOI: |
10.18203/2320-6012.ijrms20240825 |
| Availability: |
https://www.msjonline.org/index.php/ijrms/article/view/13175; https://doi.org/10.18203/2320-6012.ijrms20240825 |
| Rights: |
Copyright (c) 2024 International Journal of Research in Medical Sciences |
| Accession Number: |
edsbas.23EB343A |
| Database: |
BASE |