The pathobiology of IL-11 in kidney disease: from epithelial cell to fibroblast and back again
| Title: | The pathobiology of IL-11 in kidney disease: from epithelial cell to fibroblast and back again |
|---|---|
| Authors: | Widjaja, AA; Cook, SA |
| Source: | 1912 ; 1910 |
| Publisher Information: | Elsevier |
| Publication Year: | 2023 |
| Collection: | Imperial College London: Spiral |
| Subject Geographic: | United States |
| Description: | Up to 25% of adults >60 years of age have chronic kidney disease (CKD), which represents a growing global health challenge. Some progress has been made in treating kidney diseases in recent years, but CKD for the most part remains progressive and leads to end-stage kidney disease, with the subsequent need for renal replacement therapy (life-long dialysis or renal transplantation). Although CKD can arise from a multitude of factors, including infections, obstructions, toxins, genetics, hemodynamics, and metabolic issues, renal fibrosis emerges as a common consequence of each of these triggers. Of all the CKD pathologies, extent of fibrosis most accurately predicts progression to end-stage kidney disease and poor clinical outcomes. |
| Document Type: | article in journal/newspaper |
| Language: | English |
| Relation: | American Journal of Pathology; http://hdl.handle.net/10044/1/107075 |
| DOI: | 10.1016/j.ajpath.2023.09.011 |
| Availability: | http://hdl.handle.net/10044/1/107075; https://doi.org/10.1016/j.ajpath.2023.09.011 |
| Rights: | Copyright © 2023 American Society for Investigative Pathology. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0). ; https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: | edsbas.2404123A |
| Database: | BASE |