Characterization of Age-Associated, Neutrophil-to-Lymphocyte Ratio (NLR) and Systemic Immune-Inflammatory Index (SII) as Biomarkers of Inflammation in Geriatric Patients with Cancer Treated with Immune Checkpoint Inhibitors: Impact on Efficacy and Survival
| Title: | Characterization of Age-Associated, Neutrophil-to-Lymphocyte Ratio (NLR) and Systemic Immune-Inflammatory Index (SII) as Biomarkers of Inflammation in Geriatric Patients with Cancer Treated with Immune Checkpoint Inhibitors: Impact on Efficacy and Survival |
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| Authors: | Choucair K.; Nebhan C.; Cortellini A.; Hentzen S.; Wang Y.; Liu C.; Giusti R.; Filetti M.; Ascierto P. A.; Vanella V.; Galetta D.; Catino A.; Al-Bzour N.; Saeed A.; Cavalcante L.; Pizzutilo P.; Genova C.; Bersanelli M.; Buti S.; Johnson D. B.; Fulgenzi C. A. M.; Pinato D. J.; Radford M.; Kim C.; Naqash A. R. |
| Contributors: | Choucair, K.; Nebhan, C.; Cortellini, A.; Hentzen, S.; Wang, Y.; Liu, C.; Giusti, R.; Filetti, M.; Ascierto, P. A.; Vanella, V.; Galetta, D.; Catino, A.; Al-Bzour, N.; Saeed, A.; Cavalcante, L.; Pizzutilo, P.; Genova, C.; Bersanelli, M.; Buti, S.; Johnson, D. B.; Fulgenzi, C. A. M.; Pinato, D. J.; Radford, M.; Kim, C.; Naqash, A. R. |
| Publisher Information: | Multidisciplinary Digital Publishing Institute (MDPI); ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND |
| Publication Year: | 2023 |
| Collection: | Università degli Studi di Genova: CINECA IRIS |
| Subject Terms: | biomarker; circulating inflammatory marker; geriatric oncology; immune checkpoint inhibitor; systemic immune-inflammatory index |
| Description: | Background: Geriatric patients (≥80 years) are underrepresented in immune checkpoint inhibitor (ICIs) clinical trials. However, their unique biology may affect their response to ICIs. There are currently no established biomarkers of the response to ICIs in adult patients with cancer that can help with patient selection. Methods: We built a multicenter, international retrospective study of 885 patients ( |
| Document Type: | article in journal/newspaper |
| File Description: | ELETTRONICO |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/37894419; info:eu-repo/semantics/altIdentifier/wos/WOS:001098254500001; volume:15; firstpage:1; lastpage:12; numberofpages:12; journal:CANCERS; https://hdl.handle.net/11567/1156516 |
| DOI: | 10.3390/cancers15205052 |
| Availability: | https://hdl.handle.net/11567/1156516; https://doi.org/10.3390/cancers15205052 |
| Rights: | info:eu-repo/semantics/openAccess |
| Accession Number: | edsbas.240C2D17 |
| Database: | BASE |