Dieses Ergebnis aus BASE kann Gästen nicht angezeigt werden. Login für vollen Zugriff.

First Russian experience in liver and kidney transplantation from donors with out-of-hospital cardiac arrest: 3 years’ results ; Первый в Российской Федерации опыт пересадки печени и почек, полученных от доноров с внегоспитальной остановкой кровообращения: обобщение 3-х летних результатов

Title:	First Russian experience in liver and kidney transplantation from donors with out-of-hospital cardiac arrest: 3 years’ results ; Первый в Российской Федерации опыт пересадки печени и почек, полученных от доноров с внегоспитальной остановкой кровообращения: обобщение 3-х летних результатов
Authors:	O. N. Reznik; A. E. Skvortsov; V. S. Daineko; I. V. Loginov; A. A. Kutenkov; S. S. Komedev; V. M. Teplov; D. O. Kuzmin; A. N. Ananiev; I. V. Uliankina; D. V. Gogolev; A. A. Kukushkin; M. E. Malyshev; A. A. Boykov; V. E. Savello; A. N. Morozov; S. F. Bagnenko; О. Н. Резник; А. Е. Скворцов; В. С. Дайнеко; И. В. Логинов; А. А. Кутенков; С. С. Комедев; В. М. Теплов; Д. О. Кузьмин; А. Н. Ананьев; И. В. Ульянкина; Д. В. Гоголев; А. А. Кукушкин; М. Е. Малышев; А. А. Бойков; В. Е. Савелло; А. Н. Морозов; С. Ф. Багненко
Source:	Russian Journal of Transplantology and Artificial Organs; Том 23, № 3 (2021); 35-49 ; Вестник трансплантологии и искусственных органов; Том 23, № 3 (2021); 35-49 ; 1995-1191
Publisher Information:	Academician V.I.Shumakov National Medical Research Center of Transplantology and Artificial Organs", Ministry of Health of the Russian Federation
Publication Year:	2021
Collection:	Russian Journal of Transplantology and Artificial Organs / Вестник трансплантологии и искусственных органов
Subject Terms:	трансплантация почки; non-heart-beating donors; extracorporeal membrane oxygenation; ECMO CPR; ECMO NHBD; liver transplantation; kidney transplantation; асистолические доноры; экстракорпоральная мембранная оксигенация; ЭКМО-СЛР; ЭКМО-АСД; трансплантация печени
Description:	Introduction. In megacities, the use of organs obtained from those who died as a result of sudden out-of-hospital cardiac arrest (OHCA) for transplantation is one of the promising ways of addressing the problem of organ donor shortage. In St. Petersburg, the model of transition from life support via extracorporeal membrane oxygenation (ECMO) of patients after OHCA to ECMO life support for organs of potential donors was tested for the first time.Materials and methods. In order to implement the program, round-the-clock ECMO and transplantation teams were organized at the inpatient emergency ward of Pavlov First St. Petersburg State Medical University. Interaction with the St. Petersburg City Emergency Station, St. Petersburg was established. The protocol of work with potential donors brought to the hospital after a sudden circulatory arrest was developed, approved by the ethics committee, and implemented in clinical practice. This was the first in Russia and in international practice. Between 2017 and 2020, 67 patients with sudden OHCA were brought to the inpatient emergency ward. In 4 (5.97%) cases, advanced cardiovascular life support was successful, and 11 (16.42%) patients became effective donors. Mortality among this group of patients without subsequent postmortem donation was 77.61% (52 patients).Results. Liver transplantation from non-heart-beating donors (NHBDs) whose blood circulation was restored by ECMO (ECMO NHBD) was performed in 5 recipients who were in severe condition against the background of liver failure. In 1 (20%) case, there was severe liver allograft dysfunction for 33 days with subsequent complete restoration of function. Kidney transplantation was performed in 22 patients. Immediate graft function occurred in 10 (45.45%), while delayed function occurred in 12 (54.55%) patients. Kidney graft survival was 86.4%, kidney graft recipient survival was 95.5%, liver graft recipient survival was 80%, and the follow-up period was 24.1 ± 7.15 months.Conclusion. The use of ECMO to save the lives of ...
Document Type:	article in journal/newspaper
File Description:	application/pdf
Language:	Russian; English
Relation:	https://journal.transpl.ru/vtio/article/view/1340/1154; https://journal.transpl.ru/vtio/article/view/1340/1245; https://journal.transpl.ru/vtio/article/downloadSuppFile/1340/807; https://journal.transpl.ru/vtio/article/downloadSuppFile/1340/808; https://journal.transpl.ru/vtio/article/downloadSuppFile/1340/810; https://journal.transpl.ru/vtio/article/downloadSuppFile/1340/812; https://journal.transpl.ru/vtio/article/downloadSuppFile/1340/815; https://journal.transpl.ru/vtio/article/downloadSuppFile/1340/816; https://journal.transpl.ru/vtio/article/downloadSuppFile/1340/817; https://journal.transpl.ru/vtio/article/downloadSuppFile/1340/818; https://journal.transpl.ru/vtio/article/downloadSuppFile/1340/819; https://journal.transpl.ru/vtio/article/downloadSuppFile/1340/820; Matesanz R, Mahillo B, Alvarez Mar Carmona M. International figures on donation and transplantation – 2013. Newsletter Transplant. Spain: Organizació n Nacional de Trasplantes (ONT) – 2014.; http://www.eurotransplant.org/ , доступ 03.01.2021.; Готье СВ, Хомяков СМ. Донорство и трансплантация органов в Российской Федерации в 2017 году. Х сообщение регистра Российского трансплантологического общества. Вестник трансплантологии и искусственных органов. 2018; 20 (2): 6–28. doi:10.15825/1995-1191-2018-2-6-28.; Sánchez-Fructuoso AI, Prats D, Torrente J et al. Renal transplantation from non-heart beating donors: a promising alternative to enlarge the donor pool. J Am Soc Nephrol. 2000; 11: 350–358.; IOM: Organ Donation: Opportunities for Action. Washington, DC: National Academies Press; 2006.; Reznik ON, Bagnenko SF, Skvortsov AE. Uncontrolled Donors with Controlled Reperfusion after Sixty Minutes of Asystole: A Novel Reliable Resource for Kidney Transplantation. PloS One. 2013; 8–5: e64209.; Rudich SM, Kaplan B, Magee JC et al. Renal transplantations performed using non-heart-beating organ donors: going back to the future? Transplantation. 2002; 74: 1715–1720.; Kokkinos C, Antcliffe D, Nanidis T et al. Outcome of kidney transplantation from non-heart-beating versus heart-beating cadaveric donors. Transplantation. 2007; 83: 1193–1199.; Borry P, van Reusel W, Roels L, Schotsmans P. Donation after Uncontrolled Cardiac Death (uDCD): a review of the debate from a European perspective. J Law Med Ethics. 2008; 36: 752–759.; Blackstock MJ, Ray DC. Organ donation after circulatory death: an update. Eur J Emerg Med. 2014; 21: 324–329.; Abrams D et al. Extracorporeal membrane oxygenation in cardiopulmonary disease in adults. Journal of the American College of Cardiology. 2014; 63.25 Part A: 2769–2778.; Carroll BJ et al. Clinical features and outcomes in adults with cardiogenic shock supported by extracorporeal membrane oxygenation. The American journal of cardiology. 2015; 116.10: 1624–1630.; Mattox KL, Beall AC. Resuscitation of the moribund patient using portable cardiopulmonary bypass. The Annals of thoracic surgery. 1976; 22.5: 436–442.; Rousou JA et al. Emergency cardiopulmonary bypass in the cardiac surgical unit can be a lifesaving measure in postoperative cardiac arrest. Circulation. 1994; 90.5 Pt 2: II280–II284.; Walpoth BH et al. Accidental deep hypothermia with cardiopulmonary arrest: extracorporeal blood rewarming in 11 patients. European Journal of Cardio-thoracic surgery. 1990; 4.7: 390–393.; Mégarbane B et al. Emergency feasibility in medical intensive care unit of extracorporeal life support for refractory cardiac arrest. Intensive care medicine. 2007; 33.5: 758–764.; Nichol G et al. Systematic review of percutaneous cardiopulmonary bypass for cardiac arrest or cardiogenic shock states. Resuscitation. 2006; 70.3: 381–394.; Guenther S et al. Percutaneous extracorporeal life support for patients in therapy refractory cardiogenic shock: initial results of an interdisciplinary team. Interactive cardiovascular and thoracic surgery. 2014; 18.3: 283– 291.; Chamogeorgakis T et al. Outcomes of axillary artery side graft cannulation for extracorporeal membrane oxygenation. The Journal of thoracic and cardiovascular surgery. 2013; 145.4: 1088–1092.; Grasselli G et al. Percutaneous vascular cannulation for extracorporeal life support (ECLS): a modified technique. The International journal of artificial organs. 2010; 33.8: 553–557.; Avalli L et al. Percutaneous left-heart decompression during extracorporeal membrane oxygenation: an alternative to surgical and transeptal venting in adult patients. Asaio Journal. 2011; 57.1: 38–40.; Cardarelli MG, Young AJ, Griffith B. Use of extracorporeal membrane oxygenation for adults in cardiac arrest (E-CPR): a meta-analysis of observational studies. Asaio Journal. 2009; 55.6: 581–586.; Morimura N et al. Extracorporeal cardiopulmonary resuscitation for out-of-hospital cardiac arrest: a review of the Japanese literature. Resuscitation. 2011; 82.1: 10–14.; Biarent D. International Liaison Committee on Resuscitation.: 2005 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations. Circulation. 2005; 112.22: 1–136.; ECC Committee. 2005 American Heart Association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation. 2005; 112.24 Suppl: IV1–IV203.; Childress JF. Organ donation after circulatory determination of death: lessons and unresolved controversies. J Law Med Ethics. 2008; 36: 766–771.; Rodriguez-Arias D, Deballon IO. Protocols for uncontrolled donation after circulatory death. Lancet. 2012; 379: 1275–1276.; Hosgood SA, Patel M, Nicholson ML. The conditioning effect of ex vivo normothermic perfusion in an experimental kidney model. J Surg Res. 2013; 182: 153–160.; Ravikumar R, Jassem W, Mergental H et al. Liver transplantation after ex vivo normothermic machine preservation: a phase 1 (first-in-man) clinical trial. Am J Transplant. 2016; 16: 1779–1787.; Van Raemdonck D, Neyrinck A, Cypel M, Keshavjee S. Ex vivo lung perfusion. Transpl Int. 2015; 28 (6): 643– 656.; Ardehali A, Esmailian F, Deng M et al. Ex vivo perfusion of donor hearts for human heart transplantation (PROCEED II): a prospective, open-label, multicentre, randomised non-inferiority trial. Lancet. 2015; 385: 2577– 2584.; Скворцов АЕ. Применение экстракорпоральной нормотермической аппаратной перфузии у асистолических доноров почек: Дис. … канд. мед. наук. М., 2010.; Miñambres E, Rubio JJ, Coll E, Domínguez-Gil B. Donation after circulatory death and its expansion in Spain. Curr Opin Organ Transplant. 2018 Feb; 23 (1): 120– 129. doi:10.1097/MOT.0000000000000480. PMID: 29120882.; Lomero M, Gardiner D, Coll E, Haase-Kromwijk B, Procaccio F, Immer F et al. European Committee on Organ Transplantation of the Council of Europe (CD-P-TO). Donation after circulatory death today: an updated overview of the European landscape. Transpl Int. 2020; 33: 76–88.; Ortega-Deballon I, Hornby L, Shemie SD. Protocols for uncontrolled donation after circulatory death: a systematic review of international guidelines, practices and transplant outcomes. Crit Care. 2015; 19: 268.; Zanierato M, Dondossola D, Palleschi A, Zanella A. Donation after circulatory death: possible strategies for insitu organ preservation. Minerva Anestesiol. 2020 Sep; 86 (9): 984–991. doi:10.23736/S0375-9393.20.14262-7. Epub 2020 Apr 6. PMID: 32251572.; Jericho Bg. Organ Donation after circulatory Death: Ethical issues and international Practices. Anesth Analg. 2019; 128: 280–285.; Wall SP, Kaufman BJ, Gilbert AJ et al. NYC UDCDD Study Group. Derivation of the uncontrolled donation after circulatory determination of death protocol for New York City. Am J Transplant. 2011; 11: 1417–1426.; Giannini A, Abelli M, Azzoni G, Biancofiore G, Citterio F, Geraci P et al. Working group on DCD of Italian society of anesthesiology, analgesia and intensive care (SIAARTI); Italian society for organ transplantation. «Why can’t I give you my organs after my heart has stopped beating?» an overview of the main clinical, organisational, ethical and legal issues concerning organ donation after circulatory death in Italy. Minerva Anestesiol. 2016; 82: 359–368.; Bein T, Müller T, Citerio G. Determination of brain death under extracorporeal life support. Intensive Care Med. 2019 Mar; 45 (3): 364–366. doi:10.1007/s00134-018-05510-z. Epub 2019 Jan 9. PMID: 30627781.; Roncon-Albuquerque R Jr, Gaião S, Figueiredo P et al. An integrated program of extracorporeal membrane oxygenation (ECMO) assisted cardiopulmonary resuscitation and uncontrolled donation after circulatory determination of death in refractory cardiac arrest. Resuscitation. 2018; 133: 88–94.; Domínguez-gil B, Duranteau J, Mateos A, Núñez Jr, Cheisson G, Corral E et al. Uncontrolled donation after circulatory death: European practices and recommendations for the development and optimization of an effective programme. Transpl Int. 2016; 29: 842–859.; Savier E, Dondero F, Vibert E, Eyraud D, Brisson H, Riou B et al. Donation after cardiac Death study group. First experience of liver transplantation with type 2 donation after cardiac death in France. Liver Transpl. 2015; 21: 631–643.; Zanierato M, Dondossola D, Palleschi A, Zanella A. Donation after circulatory death: possible strategies for in situ organ preservation. Minerva anestesiol. 2020; 86: 984–991. doi:10.23736/s0375-9393.20.14262-7.; Miñambres E, Suberviola B, Guerra C, Lavid N, Lassalle M, González-Castro A, Ballesteros MA. Experience of a Maastrich type II non heart beating donor program in a small city: preliminary results. Med Intensiva. 2015 Oct; 39 (7): 433–441. English, Spanish. doi:10.1016/j.medin.2014.09.007. Epub 2014 Nov 29. PMID: 25444059.; Dalle Ave AL, Shaw DM, Bernat JL. Ethical issues in the use of extracorporeal membrane oxygenation in controlled donation after circulatory determination of death. Am J Transplant. 2016; 16: 2293–2299.; Tsui SSL, Oniscu GC. Extending normothermic regional perfusion to the thorax in donors after circulatory death. Curr Opin Organ Transplant. 2017; 22: 245–250.; Demos DS, Iyengar A, Bryner BS, Gray BW, Hoffman HR, Cornell MS et al. Successful Porcine Renal Transplantation After 60 Minutes of Donor Warm Ischemia: Extracorporeal Perfusion and Thrombolytics. ASAIO J. 2015 Jul-Aug; 61 (4): 474–479. doi:10.1097/MAT.0000000000000228. PMID: 25851315; PMCID: PMC4486602.; Reznik O, Skvortsov A, Loginov I, Ananyev A, Bagnenko S, Noysyuk Y. Kidney from uncontrolled donors after cardiac death with one hour warm ischemic time: resuscitation by extracorporal normothermic abdominal perfusion «in situ» by leukocytes-free oxygenated blood. Clin Transplant. 2011; 25 (4): 511–516.; Divithotawela С, Сypel M, Martinu T, Singer LG, Binnie M, Chow CW et al. Long-term outcomes of lung transplant with ex vivo lung Perfusion. JaMa Surg. 2019; 154: 1143–1150.; Sanchez-Escuredo A, Diekmann F, Revuelta I et al. An mTOR-inhibitor-based protocol and calcineurin inhibitor (CNI)-free treatment in kidney transplant recipients from donors after cardiac death: good renal function, but high incidence of conversion to CNI. Transpl Int. 2016; 29: 362–368.; https://journal.transpl.ru/vtio/article/view/1340
DOI:	10.15825/1995-1191-2021-3-35-49
Availability:	https://journal.transpl.ru/vtio/article/view/1340; https://doi.org/10.15825/1995-1191-2021-3-35-49
Rights:	Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access). ; Авторы, публикующие в данном журнале, соглашаются со следующим:Авторы сохраняют за собой авторские права на работу и предоставляют журналу право первой публикации работы на условиях лицензии Creative Commons Attribution License, которая позволяет другим распространять данную работу с обязательным сохранением ссылок на авторов оригинальной работы и оригинальную публикацию в этом журнале.Авторы сохраняют право заключать отдельные контрактные договорённости, касающиеся не-эксклюзивного распространения версии работы в опубликованном здесь виде (например, размещение ее в институтском хранилище, публикацию в книге), со ссылкой на ее оригинальную публикацию в этом журнале.Авторы имеют право размещать их работу в сети Интернет (например в институтском хранилище или персональном сайте) до и во время процесса рассмотрения ее данным журналом, так как это может привести к продуктивному обсуждению и большему количеству ссылок на данную работу (См. The Effect of Open Access).
Accession Number:	edsbas.244018E8
Database:	BASE