| Title: |
Results of kidney transplantation in patients with end-stage renal failure caused by autosomal dominant polycystic kidney disease |
| Authors: |
V. S. Daineko; A. N. Ananiev; E. S. Nevirovich; A. E. Skvorcov; S. A. Budylev; А. N. Selivanov; M. M. Moskalenko; V. A. Manukovskiy; O. N. Reznik |
| Source: |
Вестник трансплантологии и искусственных органов, Vol 21, Iss 2, Pp 39-48 (2019) |
| Publisher Information: |
Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov |
| Publication Year: |
2019 |
| Collection: |
Directory of Open Access Journals: DOAJ Articles |
| Subject Terms: |
autosomal dominant polycystic kidney disease; kidney transplantation; Surgery; RD1-811 |
| Description: |
Aim. To investigate the renal transplantation results for patients with end-stage renal disease (ESRD) due to autosomal dominant polycystic kidney disease (PKD).Materials and methods. The study included a prospective and retrospective analysis of the kidney transplantation results in 46 patients with ESRD caused by PKD, performed in the period from 2003 to 2018. Two groups of patients were formed. The comparison group consisted of 23 (50%) cases of kidney transplantation in patients whose polycystic-changed kidneys were preserved at the time of transplantation. The study group included 23 (50%) patients who underwent pretransplantation nephrectomy of native kidneys for clinical indications or to prepare for the waiting list. During the study, an algorithm of examination and surgical preparation for inclusion patients with PKD in the waiting list for kidney transplantation was developed and actively used.Results. The mean follow up period of patients who underwent pretransplantation nephrectomy was 3.6 ± 2.5 years, patients with preserved native kidneys - 5.3 ± 3.08 years (p > 0.05). Periodic pain in the lumbar region disturbed 12 (52.2%) patients with preserved polycystic-changed kidneys. The frequency of episodes of leukocyturia, bacteriuria and(or) hematuria significantly differed and amounted to 0.27 ± 0.35 cases per year in the study group, 1.49 ± 0.54 (p < 0.05) in the comparison group. Posttransplant nephrectomy of polycystic-changed kidneys at different times after transplantation was required in 5 (21.7%) patients. Five-year graft survival in the study group was 87.5%, in the comparison group - 76.1%. Among the patients of the comparison group, 76.4% of transplants lost their function after 10 years. The 5 and 10-year survival rates of patients with preserved native kidneys were 90.5% and 80%, respectively. In particular, there was one fatal outcome due to sepsis on the background of infection with cysts of preserved polycystic kidney. There were no deaths in the study group.Conclusion. Among ... |
| Document Type: |
article in journal/newspaper |
| Language: |
Russian |
| Relation: |
https://journal.transpl.ru/vtio/article/view/1019; https://doaj.org/toc/1995-1191; https://doaj.org/article/ffe397cabfa5457ebb599d20c72ec879 |
| DOI: |
10.15825/1995-1191-2019-2-39-48 |
| Availability: |
https://doi.org/10.15825/1995-1191-2019-2-39-48; https://doaj.org/article/ffe397cabfa5457ebb599d20c72ec879 |
| Accession Number: |
edsbas.247E9B9 |
| Database: |
BASE |