| Title: |
Cardiac stereotactic ablative radiotherapy for control of refractory ventricular tachycardia: initial UK multicentre experience |
| Authors: |
Lee, J.; Bates, M.; Shepherd, E.; Riley, S.; Henshaw, M.; Metherall, P.; Daniel, J.; Blower, A.; Scoones, D.; Wilkinson, M.; Richmond, N.; Robinson, C.; Cuculich, P.; Hugo, G.; Seller, N.; McStay, R.; Child, N.; Thornley, A.; Kelland, N.; Atherton, P.; Peedell, C.; Hatton, M. |
| Publisher Information: |
BMJ |
| Publication Year: |
2021 |
| Collection: |
White Rose Research Online (Universities of Leeds, Sheffield & York) |
| Description: |
Background: Options for patients with ventricular tachycardia (VT) refractory to antiarrhythmic drugs and/or catheter ablation remain limited. Stereotactic radiotherapy has been described as a novel treatment option. Methods: Seven patients with recurrent refractory VT, deemed high risk for either first time or redo invasive catheter ablation, were treated across three UK centres with non-invasive cardiac stereotactic ablative radiotherapy (SABR). Prior catheter ablation data and non-invasive mapping were combined with cross-sectional imaging to generate radiotherapy plans with aim to deliver a single 25 Gy treatment. Shared planning and treatment guidelines and prospective peer review were used. Results: Acute suppression of VT was seen in all seven patients. For five patients with at least 6 months follow-up, overall reduction in VT burden was 85%. No high-grade radiotherapy treatment-related side effects were documented. Three deaths (two early, one late) occurred due to heart failure. Conclusions: Cardiac SABR showed reasonable VT suppression in a high-risk population where conventional treatment had failed. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| ISSN: |
2053-3624 |
| Relation: |
https://eprints.whiterose.ac.uk/id/eprint/181746/1/e001770.full.pdf; Lee, J. orcid.org/0000-0003-2444-0169 , Bates, M., Shepherd, E. et al. (19 more authors) (2021) Cardiac stereotactic ablative radiotherapy for control of refractory ventricular tachycardia: initial UK multicentre experience. Open Heart, 8 (2). e001770. ISSN: 2053-3624 |
| Availability: |
https://eprints.whiterose.ac.uk/id/eprint/181746/; https://eprints.whiterose.ac.uk/id/eprint/181746/1/e001770.full.pdf |
| Rights: |
cc_by_nc_4 |
| Accession Number: |
edsbas.24EEC8FC |
| Database: |
BASE |