| Title: |
Multifunctional dietary approach reduces intestinal inflammation in relation with changes in gut microbiota composition in subjects at cardiometabolic risk: the SINFONI project |
| Authors: |
Hornero-Ramirez, Hugo; Morissette, Arianne; Marcotte, Bruno; Penhoat, Armelle; Lecomte, Béryle; Panthu, Baptiste; Lessard Lord, Jacob; Thirion, Florence; Van-Den-Berghe, Laurie; Blond, Emilie; Simon, Chantal; Caussy, Cyrielle; Feugier, Nathalie; Doré, Joël; Sanoner, Philippe; Meynier, Alexandra; Desjardins, Yves; Pilon, Geneviève; Marette, André; Cani, Patrice D.; Laville, Martine; Vinoy, Sophie; Michalski, Marie-Caroline; Nazare, Julie-Anne |
| Contributors: |
UCL - SSS/LDRI - Louvain Drug Research Institute; UCL - SSS/IREC - Institut de recherche expérimentale et clinique |
| Source: |
Gut Microbes, Vol. 17, no.1, p. 2438823 (2025) |
| Publisher Information: |
Informa UK Limited |
| Publication Year: |
2025 |
| Collection: |
DIAL@USL-B (Université Saint-Louis, Bruxelles) |
| Description: |
The development of cardiometabolic (CM) diseases is associated with chronic low-grade inflammation, partly linked to alterations of the gut microbiota (GM) and reduced intestinal integrity. The SINFONI project investigates a multifunctional (MF) nutritional strategy's impact combining different bioactive compounds on inflammation, GM modulation and CM profile. In this randomized crossover-controlled study, 30 subjects at CM-risk consumed MF cereal-products, enriched with polyphenols, fibers, slowly-digestible starch, omega-3 fatty acids or Control cereal-products (without bioactive compounds) for 2 months. Metabolic endotoxemia (lipopolysaccharide (LPS), lipopolysaccharide-binding protein over soluble cluster of differentiation-14 (LBP/sCD14), systemic inflammation and cardiovascular risk markers, intestinal inflammation, CM profile and response to a one-week fructose supplementation, were assessed at fasting and post mixed-meal. GM composition and metabolomic analysis were conducted. Mixed linear models were employed, integrating time (pre/post), treatment (MF/control), and sequence/period. Compared to control, MF intervention reduced intestinal inflammation (fecal calprotectin, p = 0.007) and endotoxemia (fasting LPS, p < 0.05), without alteration of systemic inflammation. MF decreased serum branched-chain amino acids compared to control (p < 0.05) and increased B.ovatus, B.uniformis, A.butyriciproducens and unclassified Christensenellaceae.CAG-74 (p < 0.05). CM markers were unchanged. A 2-month dietary intervention combining multiple bioactive compounds improved intestinal inflammation and induced GM modulation. Such strategy appears as an effective strategy to target low-grade inflammation through multi-target approach. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
boreal:298776; http://hdl.handle.net/2078.1/298776 |
| DOI: |
10.1080/19490976.2024.2438823 |
| Availability: |
http://hdl.handle.net/2078.1/298776; https://doi.org/10.1080/19490976.2024.2438823 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.24F505F7 |
| Database: |
BASE |