| Title: |
Functional motor phenotypes: to lump or to split? |
| Authors: |
Tinazzi M.; Geroin C.; Marcuzzo E.; Cuoco S.; Ceravolo R.; Mazzucchi S.; Pilotto A.; Padovani A.; Romito L. M.; Eleopra R.; Zappia M.; Nicoletti A.; Dallocchio C.; Arbasino C.; Bono F.; Magro G.; Demartini B.; Gambini O.; Modugno N.; Olivola E.; Bonanni L.; Zanolin E.; Albanese A.; Ferrazzano G.; De Micco R.; Lopiano L.; Calandra-Buonaura G.; Petracca M.; Esposito M.; Pisani A.; Manganotti P.; Tesolin L.; Teatini F.; Ercoli T.; Morgante F.; Erro R. |
| Contributors: |
Tinazzi M.; Geroin C.; Marcuzzo E.; Cuoco S.; Ceravolo R.; Mazzucchi S.; Pilotto A.; Padovani A.; Romito L.M.; Eleopra R.; Zappia M.; Nicoletti A.; Dallocchio C.; Arbasino C.; Bono F.; Magro G.; Demartini B.; Gambini O.; Modugno N.; Olivola E.; Bonanni L.; Zanolin E.; Albanese A.; Ferrazzano G.; De Micco R.; Lopiano L.; Calandra-Buonaura G.; Petracca M.; Esposito M.; Pisani A.; Manganotti P.; Tesolin L.; Teatini F.; Ercoli T.; Morgante F.; Erro R. |
| Publication Year: |
2021 |
| Collection: |
Università degli studi di Torino: AperTo (Archivio Istituzionale ad Accesso Aperto) |
| Subject Terms: |
Functional dystonia; Functional neurological disorder; Functional tremor; Functional weakne; Non-motor feature; Psychogenic movement disorders |
| Description: |
Introduction: Functional motor disorders (FMDs) are usually categorized according to the predominant phenomenology; however, it is unclear whether this phenotypic classification mirrors the underlying pathophysiologic mechanisms. Objective: To compare the characteristics of patients with different FMDs phenotypes and without co-morbid neurological disorders, aiming to answer the question of whether they represent different expressions of the same disorder or reflect distinct entities. Methods: Consecutive outpatients with a clinically definite diagnosis of FMDs were included in the Italian registry of functional motor disorders (IRFMD), a multicenter data collection platform gathering several clinical and demographic variables. To the aim of the current work, data of patients with isolated FMDs were extracted. Results: A total of 176 patients were included: 58 with weakness, 40 with tremor, 38 with dystonia, 23 with jerks/facial FMDs, and 17 with gait disorders. Patients with tremor and gait disorders were older than the others. Patients with functional weakness had more commonly an acute onset (87.9%) than patients with tremor and gait disorders, a shorter time lag from symptoms onset and FMDs diagnosis (2.9 ± 3.5 years) than patients with dystonia, and had more frequently associated functional sensory symptoms (51.7%) than patients with tremor, dystonia and gait disorders. Patients with dystonia complained more often of associated pain (47.4%) than patients with tremor. No other differences were noted between groups in terms of other variables including associated functional neurological symptoms, psychiatric comorbidities, and predisposing or precipitating factors. Conclusions: Our data support the evidence of a large overlap between FMD phenotypes. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/33961091; info:eu-repo/semantics/altIdentifier/wos/WOS:000648305300001; firstpage:1; lastpage:7; numberofpages:7; journal:JOURNAL OF NEUROLOGY; http://hdl.handle.net/2318/1795042; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85105524037 |
| DOI: |
10.1007/s00415-021-10583-w |
| Availability: |
http://hdl.handle.net/2318/1795042; https://doi.org/10.1007/s00415-021-10583-w |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.250F7A41 |
| Database: |
BASE |