| Title: |
Medical thoracoscopy with talc poudrage and indwelling pleural catheter insertion versus medical thoracoscopy with talc poudrage alone for patients with symptomatic malignant pleural effusion (TACTIC): A randomised, controlled phase 3 trial |
| Authors: |
Dipper, Alexandra; Sundaralingam, Anand; Hedley, Emma; Gudur, Sharada; Mills, Janet; Sowden, Sandra; Corcoran, John P; Daneshvar, Cyrus; Craig, Chris; Moore, Andrew J; Milne, Alice; Clive, Amelia; Bhatnagar, Rahul; Roberts, Mark E; Nagarajan, Thapas; Kutubudin, Farheen; Wassal, Helen; Aboushehata, Moustafa; Iftikhar, Sana; Haris, Mohammed; Abraham, Manjumol; Sudhir, Rajini; Panchal, Rakesh K; de Fonseka, Duneesha; Bedawi, Eihab O; Iqbal, Beenish; Addala, Dinesh; Wrightson, John; Menzies, Daniel; Ratushnyak, Svetlana; Luengo-Fernandez, Ramon; Miller, Robert F; White, Paul; Munavvar, Mohammed; Rahman, Najib M; Maskell, Nick |
| Publisher Information: |
Elsevier |
| Publication Year: |
2026 |
| Collection: |
University of the West of England, Bristol: UWE Research Repository |
| Description: |
BackgroundPatients with suspected malignant pleural effusions (MPE) are often in need of both a confirmatory diagnosis and symptom control. Therapeutic options include talc pleurodesis via chest drain, poudrage during medical thoracoscopy, or alternatively an indwelling pleural catheter (IPC). Combining the diagnostic and therapeutic efficacy of medical thoracoscopy and poudrage with the ambulatory benefits of an IPC has not been studied within a randomised controlled trial. The aim of the TACTIC trial was to determine whether this approach resulted in a reduced length of hospital stay and improvements in dyspnoea.MethodsThis unblinded, phase 3, randomised controlled trial was undertaken in 11 UK hospitals. Patients with MPE and confirmed malignancy (during medical thoracoscopy or beforehand) received talc poudrage and were randomly assigned by a centralised web-based system to an IPC at the time of medical thoracoscopy or usual care (ie, medical thoracoscopy, poudrage, and admission with large bore tube). Co-primary outcomes were time in hospital (including initial admission for trial procedure and any subsequent readmissions over 4 weeks post procedure) and average breathlessness assessed with visual analogue scale dyspnoea scores, measuring severity of dyspnoea from 0 mm to 100 mm, over a 4-week period. All randomised patients in whom an outcome was available were included in the analysis on a modified intention-to-treat basis. TACTIC was registered with ISRCTN on Aug 8, 2021 (ISRCTN11058680).FindingsParticipants were recruited from between Dec 15, 2021, and Jan 3, 2024. 124 participants were randomised: 62 to the intervention and 62 to standard care. Leading diagnoses were pleural mesothelioma (46%), lung cancer (28%), and breast cancer (10%). Co-primary outcome data were available for 102 patients for total length of hospital stay (52 in intervention group vs 50 in standard care group) and 108 patients for breathlessness (57 vs 51). Median time in hospital was 1 day (IQR 1–3, 95% CI 1–2) in the intervention ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
2213-2600 |
| Relation: |
https://uwe-repository.worktribe.com/file/15313578/1/Medical%20thoracoscopy%20with%20talc%20poudrage%20and%20indwelling%20pleural%20catheter%20insertion%20versus%20medical%20thoracoscopy%20with%20talc%20poudrage%20alone%20for%20patients%20with%20symptomatic%20malignant%20pleural%20effusion%20%28TACTIC%29%3A%20a%20randomised,%20controlled%20phase%203%20trial; https://uwe-repository.worktribe.com/output/15313578 |
| Availability: |
https://uwe-repository.worktribe.com/output/15313578 |
| Rights: |
openAccess |
| Accession Number: |
edsbas.252B5932 |
| Database: |
BASE |