| Title: |
Acceptance and commitment therapy for patient fatigue interference and caregiver burden in advanced gastrointestinal cancer: Results of a pilot randomized trial |
| Authors: |
Mosher, Catherine E; Secinti, Ekin; Wu, Wei; Kashy, Deborah A; Kroenke, Kurt; Bricker, Jonathan B; Helft, Paul R; Turk, Anita A; Loehrer, Patrick J; Sehdev, Amikar; Al-Hader, Ahmad A; Champion, Victoria L; Johns, Shelley A |
| Contributors: |
national cancer institute |
| Source: |
Palliative Medicine ; volume 36, issue 7, page 1104-1117 ; ISSN 0269-2163 1477-030X |
| Publisher Information: |
SAGE Publications |
| Publication Year: |
2022 |
| Description: |
Background: Fatigue often interferes with functioning in patients with advanced cancer, resulting in increased family caregiver burden. Acceptance and commitment therapy, a promising intervention for cancer-related suffering, has rarely been applied to dyads coping with advanced cancer. Aim: To examine the feasibility, acceptability, and preliminary efficacy of acceptance and commitment therapy for patient-caregiver dyads coping with advanced gastrointestinal cancer. Primary outcomes were patient fatigue interference and caregiver burden. Design: In this pilot trial, dyads were randomized to six weekly sessions of telephone-delivered acceptance and commitment therapy or education/support, an attention control. Outcomes were assessed at baseline and at 2 weeks and 3 months post-intervention. Setting/participants: Forty patients with stage III–IV gastrointestinal cancer and fatigue interference and family caregivers with burden or distress were recruited from two oncology clinics and randomized. Results: The eligibility screening rate (54%) and retention rate (81% at 2 weeks post-intervention) demonstrated feasibility. At 2 weeks post-intervention, acceptance and commitment therapy participants reported high intervention helpfulness (mean = 4.25/5.00). Group differences in outcomes were not statistically significant. However, when examining within-group change, acceptance and commitment therapy patients showed moderate decline in fatigue interference at both follow-ups, whereas education/support patients did not show improvement at either follow-up. Acceptance and commitment therapy caregivers showed medium decline in burden at 2 weeks that was not sustained at 3 months, whereas education/support caregivers showed little change in burden. Conclusions: Acceptance and commitment therapy showed strong feasibility, acceptability, and promise and warrants further testing. Trial Registration: ClinicalTrials.gov NCT04010227. Registered 8 July 2019, ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1177/02692163221099610 |
| Availability: |
https://doi.org/10.1177/02692163221099610; https://journals.sagepub.com/doi/pdf/10.1177/02692163221099610; https://journals.sagepub.com/doi/full-xml/10.1177/02692163221099610 |
| Rights: |
https://journals.sagepub.com/page/policies/text-and-data-mining-license |
| Accession Number: |
edsbas.252FBD8B |
| Database: |
BASE |