| Title: |
NeuroArray: A Customized aCGH for the Analysis of Copy Number Variations in Neurological Disorders |
| Authors: |
La Cognata, Valentina; Morello, Giovanna; Gentile, Giulia; Cavalcanti, Francesca; Cittadella, Rita; Conforti, Francesca Luisa; De Marco, Elvira Valeria; Magariello, Angela; Muglia, Maria; Patitucci, Alessandra; Spadafora, Patrizia; D'Agata, Velia; Ruggieri, Martino; Cavallaro, Sebastiano |
| Source: |
Current genomics 19 (2018): 431–443. doi:10.2174/1389202919666180404105451 ; info:cnr-pdr/source/autori:La Cognata, Valentina; Morello, Giovanna; Gentile, Giulia; Cavalcanti, Francesca; Cittadella, Rita; Conforti, Francesca Luisa; De Marco, Elvira Valeria; Magariello, Angela; Muglia, Maria; Patitucci, Alessandra; Spadafora, Patrizia; D'Agata, Velia; Ruggieri, Martino; Cavallaro, Sebastiano/titolo:NeuroArray: A Customized aCGH for the Analysis of Copy Number Variations in Neurological Disorders/doi:10.21741389202919666180404105451/rivista:Current genomics/anno:2018/pagina_da:431/pagina_a:443/intervallo_pagine:431–443/volume:19 |
| Publisher Information: |
Bentham Science Publishers, Hilversum , Paesi Bassi |
| Publication Year: |
2018 |
| Collection: |
PUMAlab (ISTI CNR - Consiglio Nazionale delle Ricerche / National Research Council) |
| Subject Terms: |
Methods; aCGH; CNVs; Neurological diseases; Genes; Custom array |
| Description: |
Background: Neurological disorders are a highly heterogeneous group of pathological conditions that affect both the peripheral and the central nervous system. These pathologies are characterized by a complex and multifactorial etiology involving numerous environmental agents and genetic susceptibility factors. For this reason, the investigation of their pathogenetic basis by means of traditional methodological approaches is rather arduous. High-throughput genotyping technologies, including the microarray-based comparative genomic hybridization (aCGH), are currently replacing classical detection methods, providing powerful molecular tools to identify genomic unbalanced structural rearrangements and explore their role in the pathogenesis of many complex human diseases. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:cnr-pdr/author/idpersonaleesterno:21822/LA COGNATA/VALENTINA; info:cnr-pdr/author/idpersonaleesterno:28467/MORELLO/GIOVANNA; info:cnr-pdr/author/matricola:4172/DE MARCO/ELVIRA VALERIA; info:cnr-pdr/author/matricola:5327/CAVALLARO/SEBASTIANO; info:cnr-pdr/author/matricola:5735/D'AGATA/VELIA MARIA; info:cnr-pdr/author/matricola:5808/CAVALCANTI/FRANCESCA; info:cnr-pdr/author/matricola:5809/CONFORTI/FRANCESCA LUISA; info:cnr-pdr/author/matricola:5813/SPADAFORA/PATRIZIA; info:cnr-pdr/author/matricola:8035/RUGGIERI/MARTINO; info:cnr-pdr/author/matricola:8233/PATITUCCI/ALESSANDRA; info:cnr-pdr/author/matricola:9874/MAGARIELLO/ANGELA; info:cnr-pdr/author/matricola:17223/GUARNACCIA/MARIA; info:cnr-pdr/author/matricola:17224/GENTILE/GIULIA; info:cnr-pdr/author/matricola:29550/CITTADELLA/RITA; info:cnr-pdr/author/matricola:39037/MUGLIA/MARIA; http://www.cnr.it/prodotto/i/389655; https://publications.cnr.it/doc/389655; https://dx.doi.org/10.2174/1389202919666180404105451; info:doi:10.2174/1389202919666180404105451; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128384/ |
| DOI: |
10.2174/1389202919666180404105451 |
| Availability: |
http://www.cnr.it/prodotto/i/389655; https://publications.cnr.it/doc/389655; https://doi.org/10.2174/1389202919666180404105451; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128384/ |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.2572D82E |
| Database: |
BASE |