| Title: |
Post-hospitalisation COVID-19 rehabilitation (PHOSP-R): a randomised controlled trial of exercise-based rehabilitation |
| Authors: |
Daynes, Enya; Evans, Rachael A.; Greening, Neil J.; Bishop, Nicolette C.; Yates, Thomas; Lozano-Rojas, Daniel; Ntotsis, Kimon; Richardson, Matthew; Baldwin, Molly M.; Hamrouni, Malik; Hume, Emily; McAuley, Hamish; Mills, George; Megaritis, Dimitrios; Roberts, Matthew; Bolton, Charlotte E.; Chalmers, James D.; Chalder, Trudie; Docherty, Annemarie B.; Elneima, Omer; Harrison, Ewen M.; Harris, Victoria C.; Ho, Ling P.; Horsley, Alex; Houchen-Wolloff, Linzy; Leavy, Olivia C.; Marks, Michael; Poinasamy, Krishna; Quint, Jennifer K.; Raman, Betty; Saunders, Ruth M.; Shikotra, Aarti; Singapuri, Amisha; Sereno, Marco; Terry, Sarah; Wain, Louise V.; Man, William D-C.; Echevarria, Carlos; Vogiatzis, Ioannis; Brightling, Christopher; Singh, Sally J.; PHOSP-COVID Study Collaborative Group, . |
| Publisher Information: |
European Respiratory Society |
| Publication Year: |
2025 |
| Collection: |
University of Glasgow: Enlighten - Publications |
| Description: |
Objective: Post-COVID syndrome involves prolonged symptoms with multisystem and functional impairment lasting ≥12 weeks after acute coronavirus disease 2019 (COVID-19). We aimed to determine the efficacy of exercise-based rehabilitation interventions, either face-to-face or remote, compared to usual care in individuals experiencing post-COVID syndrome following a hospitalisation with acute COVID-19. Design: This single-blind randomised controlled trial compared two exercise-based rehabilitation interventions (face-to-face or remote) to usual care in participants with post-COVID syndrome following a hospitalisation. The interventions were either a face-to-face or remote 8-week programme of individually prescribed exercise and education. The primary outcome was the change in Incremental Shuttle Walking Test (ISWT) following 8 weeks of intervention (either face-to-face or remote) compared to usual care. Other secondary outcomes were measured including health-related quality of life (HRQoL), and exploratory outcomes included lymphocyte immunotyping. Results: 181 participants (55% male, mean±sd age 59±12 years, length of hospital stay 12±19 days) were randomised. There was an improvement in the ISWT distance following face-to-face rehabilitation (mean 52 m, 95% CI 19–85 m; p=0.002) and remote rehabilitation (mean 34 m, 95% CI 1–66 m; p=0.047) compared to usual care alone. There were no differences between groups for HRQoL self-reported symptoms. Analysis of immune markers revealed significant increases in naïve and memory CD8+ T-cells following face-to-face rehabilitation versus usual care alone (p |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://eprints.gla.ac.uk/355456/1/355456.pdf; Daynes, E. et al. (2025) Post-hospitalisation COVID-19 rehabilitation (PHOSP-R): a randomised controlled trial of exercise-based rehabilitation. European Respiratory Journal , 65(5), 2402152. (doi:10.1183/13993003.02152-2024 ) (PMID:39978856) (PMCID:PMC12095904) |
| Availability: |
https://eprints.gla.ac.uk/355456/; https://eprints.gla.ac.uk/355456/1/355456.pdf |
| Rights: |
cc_by_4 |
| Accession Number: |
edsbas.258B6F9A |
| Database: |
BASE |