| Title: |
Influence of fractional flow reserve on grafts patency. Systematic review and patient-level meta-analysis |
| Authors: |
G. Toth G.; Collet C.; Langhoff Thuesen A.; Mizukami T.; Casselman F.; Riber L. P.; Van Praet F.; Junker A.; Nagumo S.; De Bruyne B.; Okkels Jensen L.; Barbato E. |
| Contributors: |
G. Toth, G.; Collet, C.; Langhoff Thuesen, A.; Mizukami, T.; Casselman, F.; Riber, L. P.; Van Praet, F.; Junker, A.; Nagumo, S.; De Bruyne, B.; Okkels Jensen, L.; Barbato, E. |
| Publisher Information: |
John Wiley and Sons Inc |
| Publication Year: |
2022 |
| Collection: |
Sapienza Università di Roma: CINECA IRIS |
| Subject Terms: |
coronary artery bypass surgery; fractional flow reserve; graft patency |
| Description: |
Objective: To investigate the impact of invasive functional guidance for coronary artery bypass graft surgery (CABG) on graft failure. Background: Data on the impact of fractional flow reserve (FFR) in guiding CABG are still limited. Methods: Systematic review and individual patient data meta-analysis were performed. Primary objective was the risk of graft failure, stratified by FFR. Risk estimates are reported as odds ratios (ORs) derived from the aggregated data using random-effects models. Individual patient data were analyzed using mixed effect model to assess relationship between FFR and graft failure. This meta-analysis is registered in PROSPERO (CRD42020180444). Results: Four prospective studies comprising 503 patients referred for CABG, with 1471 coronaries, assessed by FFR were included. Graft status was available for 1039 conduits at median of 12.0 [IQR 6.6; 12.0] months. Risk of graft failure was higher in vessels with preserved FFR (OR 5.74, 95% CI 1.71–19.29). Every 0.10 FFR units decrease in the coronaries was associated with 56% risk reduction of graft failure (OR 0.44, 95% CI 0.34 to 0.59). FFR cut-off to predict graft failure was 0.79. Conclusion: Surgical grafting of coronaries with functionally nonsignificant stenoses was associated with higher risk of graft failure. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/34233071; info:eu-repo/semantics/altIdentifier/wos/WOS:000670365700001; volume:99; issue:3; firstpage:730; lastpage:735; numberofpages:6; journal:CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS; https://hdl.handle.net/11573/1699870 |
| DOI: |
10.1002/ccd.29864 |
| Availability: |
https://hdl.handle.net/11573/1699870; https://doi.org/10.1002/ccd.29864 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.259FCAB9 |
| Database: |
BASE |