| Title: |
Projected health impact of post-discharge malaria chemoprevention among children with severe malarial anaemia in Africa. |
| Authors: |
Okell, Lucy C; Kwambai, Titus K; Dhabangi, Aggrey; Khairallah, Carole; Nkosi-Gondwe, Thandile; Winskill, Peter; Opoka, Robert; Mousa, Andria; Kühl, Melf-Jakob; Lucas, Tim CD; Challenger, Joseph D; Idro, Richard; Weiss, Daniel J; Cairns, Matthew; Ter Kuile, Feiko O; Phiri, Kamija; Robberstad, Bjarne; Mori, Amani Thomas |
| Publisher Information: |
Springer Science and Business Media LLC |
| Publication Year: |
2023 |
| Collection: |
London School of Hygiene & Tropical Medicine: LSHTM Research Online |
| Description: |
Children recovering from severe malarial anaemia (SMA) remain at high risk of readmission and death after discharge from hospital. However, a recent trial found that post-discharge malaria chemoprevention (PDMC) with dihydroartemisinin-piperaquine reduces this risk. We developed a mathematical model describing the daily incidence of uncomplicated and severe malaria requiring readmission among 0-5-year old children after hospitalised SMA. We fitted the model to a multicentre clinical PDMC trial using Bayesian methods and modelled the potential impact of PDMC across malaria-endemic African countries. In the 20 highest-burden countries, we estimate that only 2-5 children need to be given PDMC to prevent one hospitalised malaria episode, and less than 100 to prevent one death. If all hospitalised SMA cases access PDMC in moderate-to-high transmission areas, 38,600 (range 16,900-88,400) malaria-associated readmissions could be prevented annually, depending on access to hospital care. We estimate that recurrent SMA post-discharge constitutes 19% of all SMA episodes in moderate-to-high transmission settings. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| ISSN: |
2041-1723 |
| Relation: |
https://researchonline.lshtm.ac.uk/id/eprint/4669034/1/Okell_etal_2023_Projected-health-impact-of-post.pdf; Okell, Lucy CORCID logo; Kwambai, Titus K; Dhabangi, Aggrey; Khairallah, Carole; Nkosi-Gondwe, Thandile; Winskill, PeterORCID logo; Opoka, Robert; Mousa, Andria ORCID logo; Kühl, Melf-Jakob; Lucas, Tim CDORCID logo; +8 more.Challenger, Joseph DORCID logo; Idro, Richard; Weiss, Daniel J; Cairns, MatthewORCID logo; Ter Kuile, Feiko OORCID logo; Phiri, Kamija; Robberstad, Bjarne; and Mori, Amani ThomasORCID logo (2023) Projected health impact of post-discharge malaria chemoprevention among children with severe malarial anaemia in Africa. Nature communications, 14 (1). 402-. ISSN 2041-1723 DOI:10.1038/s41467-023-35939-w |
| DOI: |
10.1038/s41467-023-35939-w |
| Availability: |
https://researchonline.lshtm.ac.uk/id/eprint/4669034/; https://doi.org/10.1038/s41467-023-35939-w |
| Rights: |
cc_by_4 |
| Accession Number: |
edsbas.25E54254 |
| Database: |
BASE |