| Title: |
Sex differences in post-acute neurological sequelae of SARS-CoV-2 and symptom resolution in adults after coronavirus disease 2019 hospitalization: an international multi-centre prospective observational study |
| Authors: |
Cho, Sung-Min; Premraj, Lavienraj; Battaglini, Denise; Fanning, Jonathon Paul; Suen, Jacky; Bassi, Gianluigi Li; Fraser, John; Robba, Chiara; Griffee, Matthew; Solomon, Tom; Semple, Malcolm; Baillie, Kenneth; Sigfrid, Louise; Scott, Janet; Citarella, Barbara Wanjiru; Merson, Laura; Arora, Rakesh; Whitman, Glenn; Thomson, David; White, Nicole; Abel, Laurent; Abrous, Amal; Jabal, Kamal Abu; Zayyad, Hiba Abu; Tamlihat, Younes Ait; Alameen, Aliya Mohammed; Alessi, Marta; Alex, Beatrice; Alexandre, Kévin; Ali, Adam; Alidjnou, Kazali Enagnon; Allavena, Clotilde; Allou, Nathalie; Andréjak, Claire; Angheben, Andrea; Angoulvant, François; Ansart, Séverine; Arlet, Jean-Benoît; Artaud-Macari, Elise; Assie, Jean Baptiste; Auchabie, Johann; Aumaitre, Hugues; Auvet, Adrien; Axelsen, Eyvind; Azemar, Laurène; Azoulay, Cecile; Bach, Benjamin; Bachelet, Delphine; Badr, Claudine; Bævre-Jensen, Roar; Baillie, John Kenneth; Bani-Sadr, Firouzé; Barclay, Wendy; Bartoli, Marie; Baruch, Joaquín; Basmaci, Romain; Bauer, Jules; Bedossa, Alexandra; Begum, Husna; Behilill, Sylvie; Beltrame, Anna; Beluze, Marine; Benech, Nicolas; Bergeaud, Delphine; Sobrino, José Luis Bernal; Bertoli, Giulia; Bessis, Simon; Bevilcaqua, Sybille; Bezulier, Karine; Bhavsar, Krishna; Bisoffi, Zeno; Bitker, Laurent; Blot, Mathieu; Bodenes, Laetitia; Bogaert, Debby; Boivin, Anne-Hélène; Bolaños, Isabela; Bolze, Pierre-Adrien; Bompart, François; Borie, Raphaël; Botelho-Nevers, Elisabeth; Bouadma, Lila; Bouchaud, Olivier; Bouchez, Sabelline; Bouhour, Damien; Bouiller, Kévin; Bouillet, Laurence; Bouisse, Camile; Boureau, Anne-Sophie; Bouscambert, Maude; Bousquet, Aurore; Boyer-Besseyre, Marielle; Braconnier, Axelle; Brunvoll, Sonja Hjellegjerde; Buisson, Marielle; Buonsenso, Danilo; Burrell, Aidan; Bustos, Ingrid; Cabie, André; Caceres, Eder; Cadoz, Cyril; Calvache, Jose Andres; Campana, Valentine; Caraux-Paz, Pauline; Carlier, Nicolas; Carmoi, Thierry; Carret, Marie-Christine; Carson, Gail; Casanova, Maire-Laure; Castor-Alexandre, Guylaine; Catherine, François-Xavier; Cattaneo, Paolo; Cervantes-Gonzalez, Minerva; Chair, Anissa; Chakveatze, Catherine; Chand, Meera; Chapplain, Jean-Marc; Charpentier, Charlotte; Chas, Julie; Chenard, Léo; Cheret, Antoine; Chiarabini, Thibault; Chirouze, Catherine; Cholley, Bernard; Chopin, Marie-Charlotte; Chow, Yock Ping; Clohisey, Sara; Colin, Gwenhaël; Connor, Marie; Conrad, Anne; Cooke, Graham; Cordel, Hugues; Cortegiani, Andrea; Corvaisier, Grégory; Couffignal, Camille; Couffin-Cadiergues, Sandrine; Courtois, Roxane; Cousse, Stéphanie; Bermúdez, Juan Luis Cruz; Rojo, Jaime Cruz; Curlier, Elodie; da Silva Filipe, Ana; da Silveira, Charlene; Dagens, Andrew; Dahl, John Arne; Dalton, Jo; de Montmollin, Etienne; de Rose, Cristina; de Silva, Thushan; Debard, Alexa; Debray, Marie-Pierre; Decastro, Nathalie; Decours, Romain; Defous, Eve; Delacroix, Isabelle; Delaveuve, Eric; Delavigne, Karen; Delmas, Christelle; Delobel, Pierre; Demonchy, Elisa; Denis, Emmanuelle; Deplanque, Dominique; Descamps, Diane; Desvallées, Mathilde; Diallo, Alpha; Diamantis, Sylvain; da Silva, Fernanda Dias; Didier, Kévin; Diehl, Jean-Luc; Dimet, Jérôme; Dinot, Vincent; Diop, Fara; Diouf, Alphonsine; Djossou, Félix; Docherty, Annemarie; Donnelly, Christl; Dorival, Céline; d'Ortenzio, Eric; Dournon, Nathalie; Drake, Thomas; Dror, Amiel; Dubee, Vincent; Dubos, François; Ducancelle, Alexandre; Dudman, Susanne; Dunand, Paul; Dunning, Jake; Dussol, Bertrand; Duval, Xavier; Dyrhol-Riise, Anne Margarita; Edelstein, Michael; Eggesbø, Linn Margrete; Sanharawi, Mohammed El; Elharrar, Brigitte; Ellingjord-Dale, Merete; Eloy, Philippine; Enderle, Isabelle; Engelmann, Ilka; Enouf, Vincent; Epaulard, Olivier; Esperou, Hélène; Esposito-Farese, Marina; Etienne, Manuel; Evers, Mirjam; Fabre, Marc; Fabre, Isabelle; Fairfield, Cameron; Faure, Karine; Favory, Raphaël; Ferrand, François-Xavier; Devouge, Eglantine Ferrand; Ferriere, Nicolas; Ficko, Céline; Finlayson, William; Flament, Thomas; Fletcher, Tom; Florence, Aline-Marie; Fourn, Erwan; Fowler, Robert; Fraser, Christophe; Fry, Stéphanie; Gaborieau, Valérie; Gaci, Rostane; Gagnard, Jean-Charles; Gagneux-Brunon, Amandine; Gaião, Sérgio; Skeie, Linda Gail; Gamble, Carrol; Barrio, Noelia García; Garcia-Gallo, Esteban; Garot, Denis; Garrait, Valérie; Gavrylov, Anatoliy; Gaymard, Alexandre; Geraud, Eva; Morlaes, Louis Gerbaud; Ghosn, Jade; Gigante, Tristan; Giordano, Guillermo; Girvan, Michelle; Gissot, Valérie; Glikman, Daniel; Goehringer, François; Gomez, Kyle; Gominet, Marie; Gorelik, Yanay; Gorenne, Isabelle; Goubert, Laure; Goujard, Cécile; Goulenok, Tiphaine; Granier, Pascal; Green, Christopher; Greenhalf, William; Greffe, Segolène; Griffiths, Fiona; Guedj, Jérémie; Guego, Martin; Guery, Romain; Guillaumot, Anne; Guilleminault, Laurent; Guimard, Thomas; Hachemi, Ali; Hadri, Nadir; Hall, Matthew; Halpin, Sophie; Hamidfar, Rebecca; Hammarström, Bato; Hardwick, Hayley; Harrison, Ewen; Harrison, Janet; Heggelund, Lars; Hendry, Ross; Hentzien, Maxime; Hernandez, Diana; Hesstvedt, Liv; Higgins, Rupert; Hitoto, Hikombo; Ho, Antonia; Hoctin, Alexandre; Hoffmann, Isabelle; Holter, Jan Cato; Horby, Peter; Houas, Ikram; Hulot, Jean-Sébastien; Ijaz, Samreen; Imbert, Patrick; Ippolito, Mariachiara; Isnard, Margaux; Istre, Mette Stausland; Jaafar, Danielle; Jaafoura, Salma; Jabot, Julien; Jackson, Clare; Jaureguiberry, Stéphane; Jego, Florence; Jenum, Synne; Jørgensen, Silje Bakken; Joseph, Cédric; Jourdain, Mercé; Kafif, Ouifiya; Kaguelidou, Florentia; Kali, Sabina; Kalita, Deepjyoti; Kalleberg, Karl Trygve; Kartsonaki, Christiana; Keating, Seán; Kelly, Sadie; Kennon, Kalynn; Kerroumi, Younes; Khalil, Antoine; Khoo, Saye; Granerud, Beathe Kiland; Kildal, Anders Benjamin; Kimmoun, Antoine; Kjetland, Eyrun Floerecke Kjetland; Klenerman, Paul; Bekken, Gry Kloumann; Knight, Stephen; Kpangon, Arsène; Kruglova, Oksana; Kutsyna, Galyna; Lachatre, Marie; Lacoste, Marie; Lafhej, Nadhem; Lagrange, Marie; Laine, Fabrice; Lairez, Olivier; Lalueza, Antonio; Lambert, Marc; Langelot-Richard, Marie; Langlois, Vincent; Laouénan, Cédric; Laribi, Samira; Lariviere, Delphine; Lasry, Stéphane; Launay, Odile; Laureillard, Didier; Lavie-Badie, Yoan; Law, Andy; Le, Minh; Le Bihan, Clément; Le Bris, Cyril; Le Falher, Georges; Le Fevre, Lucie; Le Hingrat, Quentin; Le Maréchal, Marion; Le Mestre, Soizic; Le Moal, Gwenaël; Le Moing, Vincent; Le Nagard, Hervé; Lee, Jennifer; Leeming, Gary; Lefebvre, Laurent; Lefebvre, Bénédicte; Lefèvre, Benjamin; Legac, Sylvie; Lelievre, Jean-Daniel; Lemaignen, Adrien; Lemee, Véronique; Lemeur, Anthony; Leone, Marc; Lepiller, Quentin; Lescure, François-Xavier; Lesens, Olivier; Lesouhaitier, Mathieu; Letrou, Sophie; Levy, Yves; Levy, Bruno; Levy-Marchal, Claire; L'Her, Erwan; Liegeon, Geoffrey; Lim, Wei Shen; Lina, Bruno; Lind, Andreas; Lingas, Guillaume; Lion-Daolio, Sylvie; Livrozet, Marine; Loubet, Paul; Loufti, Bouchra; Louis, Guillame; Lucet, Jean Christophe; Bermejo, Carlos Lumbreras; Lunn, Miles; Luong, Liem; Luton, Dominique; Machado, Moïse; Macheda, Gabriel; de la Calle, Guillermo Maestro; Mahieu, Rafael; Mahy, Sophie; Maillet, Mylène; Maitre, Thomas; Malvy, Denis; Manda, Victoria; Mandelbrot, Laurent; Mankikian, Julie; Manuel, Aldric; Markowicz, Samuel; Marshall, John; Martin-Blondel, Guillaume; Martinot, Martin; Martynenko, Olga; Mattei, Mathieu; Maulin, Laurence; Mazzoni, Thierry; Mcarthur, Colin; Mcdonald, Sarah; Mclean, Kenneth; Mear-Passard, Cécile; Mentré, France; Mentzer, Alexander; Mercier, Noémie; Mercier, Emmanuelle; Merckx, Antoine; Mergeay-Fabre, Mayka; Meta, Roberta; Meybeck, Agnès; Meynert, Alison; Meysonnier, Vanina; Mezidi, Mehdi; Michelanglei, Céline; Michelet, Isabelle; Moore, Sarah; Moore, Shona; Cely, Lina Morales; Moro, Lucia; Mouquet, Hugo; Perrot, Clara Mouton; Moyet, Julien; Mullaert, Jimmy; Müller, Fredrik; Müller, Karl Erik; Murris, Marlène; Murthy, Srinivas; Neant, Nadège; Nghi, Anthony; Nguyen, Duc; Nichol, Alistair; Noursadeghi, Mahdad; Nseir, Saad; Nyamankolly, Elsa; Nygaard, Anders Benteson; Olliaro, Piero; Oosthuyzen, Wilna; Openshaw, Peter; Orozco-Chamorro, Claudia Milena; Otiku, Paul; Ouamara, Nadia; Ouissa, Rachida; Oziol, Eric; Pagadoy, Maïder; Pages, Justine; Palmarini, Massimo; Panda, Prasan Kumar; Pansu, Nathalie; Papadopoulos, Aurélie; Parke, Rachael; Pasquier, Jérémie; Pastene, Bruno; Paul, Christelle; Paxton, William; Payen, Jean-François; Jiménez, Miguel Pedrera; Peelman, Florent; Peiffer-Smadja, Nathan; Peigne, Vincent; Perez, Daniel; Perpoint, Thomas; Pestre, Vincent; Petrov-Sanchez, Ventzislava; Pettersen, Frank Olav; Peytavin, Gilles; Picard, Walter; Picone, Olivier; Piroth, Lionel; Piubelli, Chiara; Pius, Riinu; Plantier, Laurent; Poissy, Julien; Pokeerbux, Ryadh; Pollakis, Georgios; Ponscarme, Diane; Preau, Sébastien; Pritchard, Mark; González, Víctor Quirós; Quist-Paulsen, Else; Rabaud, Christian; Rafiq, Marie; Rammaert, Blandine; Rapp, Christophe; Rebaudet, Stanislas; Redl, Sarah; Reikvam, Dag Henrik; Remy, Martine; Resseguier, Anne-Sophie; Revest, Matthieu; Reyes, Luis Felipe; Ricchiuto, Antonia; Richier, Laurent; Rispal, Patrick; Risso, Karine; Roberts, Stephanie; Robertson, David; Robineau, Olivier; Rodari, Paola; Roger, Pierre-Marie; Rojek, Amanda; Roncon-Albuquerque, Roberto; Roriz, Mélanie; Rosa-Calatrava, Manuel; Rossanese, Andrea; Rossignol, Patrick; Roy, Carine; Roze, Benoît; Russell, Clark; Holten, Aleksander Rygh; Gandonniere, Charlotte Salmon; Salvator, Hélène; Sanchez, Olivier; Sancho-Shimizu, Vanessa; Sandrine, Pierre-François; Sandulescu, Oana; Sarton, Benjamine; Saviciute, Egle; Scherpereel, Arnaud; Schneider, Marion; Scott-Brown, James; Sedillot, Nicholas; Senneville, Eric; Balazote, Pablo Serrano; Shaw, Catherine; Shaw, Victoria; Sindhwani, Girish; Mohammed, Nassima Si; Sibiude, Jeanne; Sinatti, Dario; Skogen, Vegard; Smith, Sue; Solberg, Lene Bergendal; Sommet, Agnès; Søraas, Arne; Sotto, Albert; Soum, Edouard; Spinuzza, Elisabetta; Sriskandan, Shiranee; Stabler, Sarah; Steinsvik, Trude; Stiksrud, Birgitte; Streinu-Cercel, Adrian; Streinu-Cercel, Anca; Stuart, David; Su, Richa; Summers, Charlotte; Tagherset, Lysa; Tamisier, Renaud; Tardivon, Coralie; Tattevin, Pierre; Tellier, Marie-Capucine; Téoulé, François; Terrier, Olivier; Terzi, Nicolas; Thibault, Vincent; Thiberville, Simon-Djamel; Thill, Benoît; Thomson, Emma; Thorpe, Mathew; Thwaites, Ryan; Tieroshyn, Vadim; Timsit, Jean-François; Tissot, Noémie; Tonby, Kristian; Tromeur, Cécile; Trouillon, Tiffany; Truong, Jeanne; Tual, Christelle; Tubiana, Sarah; Turmel, Jean-Marie; Turtle, Lance; Tveita, Anders; Uyeki, Timothy; Valentini, Piero; van der Werf, Sylvie; Vanel, Noémie; Vauchy, Charline; Veislinger, Aurélie; Visseaux, Benoit; Vuotto, Fanny; Webb, Steve; Wei, Jia; Wham, Murray; Wicky, Paul Henri; Wiedemann, Aurélie; Wright, Natalie; Yazdanpanah, Yazdan; Yelnik, Cécile; Yonis, Hodane; Zabbe, Marion; Zambon, Maria; Zucman, David |
| Contributors: |
Ospedale Policlinico San Martino Genoa; The Prince Charles Hospital; The University of Queensland (UQ All campuses : Brisbane, Dutton Park Gatton, Herston, St Lucia and other locations ); Queensland University of Technology Brisbane (QUT); Bond University Gold Coast; Università degli studi di Genova = University of Genoa = Université de Gênes (UniGe); University of Liverpool; Alder Hey Children's Hospital; University of Bath Bath; University of Oxford; Laboratoire de Mathématiques et de leurs Applications Pau (LMAP); Université de Pau et des Pays de l'Adour (UPPA)-Centre National de la Recherche Scientifique (CNRS); University of Southampton; Human genetics of infectious diseases: Complex predisposition (Equipe Inserm U1163); Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité); French COVID cohort study group; Dynamique Microbienne associée aux Infections Urinaires et Respiratoires (DYNAMICURE); Université de Caen Normandie (UNICAEN); Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN); Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM); Service des maladies infectieuses et tropicales Rouen; CHU Rouen; Normandie Université (NU); Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes); Nantes Université (Nantes Univ); CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble (CHUGA); Université Grenoble Alpes (UGA); Service Pharmacologie Clinique CHU Toulouse; Pôle Santé publique et médecine publique CHU Toulouse; Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse); Centre d'investigation clinique de Toulouse (CIC 1436); Université Toulouse III - Paul Sabatier (UT3); Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Pôle Santé publique et médecine publique CHU Toulouse; Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Pontchaillou; ARN bactériens et médecine (BRM); Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes (Biosit : Biologie - Santé - Innovation Technologique); This work was made possible by the Foreign, Commonwealth and Development Office and Wellcome Trust (215091/Z/18/Z, 222410/Z/21/Z, 225288/Z/22/Z and 220757/Z/20/Z); the Bill and Melinda Gates Foundation (OPP1209135); the philanthropic support of the donors to the University of Oxford’s COVID-19 Research Response Fund (0009109); grants from the National Institute for Health Research (NIHR; award CO-CIN-01/DH/Department of Health/UK) and the UK Medical Research Council (MRC; grant MC_PC_19059); the NIHR Health Protection Research Unit (HPRU) in Emerging and Zoonotic Infections at the University of Liverpool in partnership with Public Health England (PHE; award 200907), the NIHR HPRU in Respiratory Infections at the Imperial College London with PHE (award 200927), the Liverpool Experimental Cancer Medicine Centre (grant C18616/A25153), the NIHR Biomedical Research Centre at the Imperial College London (award ISBRC-1215-20013) and the NIHR Clinical Research Network providing infrastructure support; the Rapid European COVID-19 Emergency Response research (RECOVER; H2020 project 101003589) and European Clinical Research Alliance on Infectious Diseases (ECRAID; 965313); the Cambridge NIHR Biomedical Research Centre (award NIHR203312); a Research Council of Norway grant no. 312780 and a philanthropic donation from Vivaldi Invest A/S owned by Jon Stephenson von Tetzchner; the Comprehensive Local Research Networks (CLRNs) (NIHR201385); Innovative Medicines Initiative Joint Undertaking under Grant Agreement No. 115523 COMBACTE, resources of which are composed of financial contribution from the Seventh Framework Programme (FP7/2007-2013) and European Federation of Pharmaceutical Industries and Associations (EFPIA) companies, in-kind contribution; the Italian Ministry of Health ‘Fondi Ricerca corrente–L1P6’ to IRCCS (Scientific Institute for Research, Hospitalization and Healthcare) Ospedale Sacro Cuore–Don Calabria; the Australian Government Department of Health grant (3273191); grants from Instituto de Salud Carlos III, Ministerio de Ciencia, Spain. The French COVID cohort (NCT04262921) is sponsored by Inserm (Institut national de la santé et de la recherche médicale) and is funded by the REACTing (REsearch & ACtion emergING infectious diseases) consortium and by a grant of the French Ministry of Health (PHRC no. 20-0424) and by the South Eastern Norway Health Authority and the Research Council of Norway. J.P.F. is funded by a Metro-North Clinical Research Fellowship, Department of Health, Queensland Government, Australia. S.-M.C. is funded by the National Heart, Lung, and Blood Institute (1K23HL157610). N.W. is funded by an Advance Queensland Industry Research Fellowship (AQIRF076-2020-CV). |
| Source: |
ISSN: 2632-1297 ; Brain Communications ; https://hal.science/hal-04831170 ; Brain Communications, 2024, 6 (2), pp.44. ⟨10.1093/braincomms/fcae036⟩. |
| Publisher Information: |
CCSD; Oxford University Press on behalf of the Guarantors of Brain |
| Publication Year: |
2024 |
| Collection: |
Université Toulouse III - Paul Sabatier: HAL-UPS |
| Subject Terms: |
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| Description: |
International audience ; Abstract Although it is known that coronavirus disease 2019 can present with a range of neurological manifestations and in-hospital complications, sparse data exist on whether these initial neurological symptoms of coronavirus disease 2019 are closely associated with post-acute neurological sequelae of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2; PANSC) and whether female versus male sex impacts symptom resolution. In this international, multi-centre, prospective, observational study across 407 sites from 15 countries (30 January 2020 to 30 April 2022), we report the prevalence and risk factors of PANSC among hospitalized adults and investigate the differences between males and females on neurological symptom resolution over time. PANSC symptoms included altered consciousness/confusion, fatigue/malaise, anosmia, dysgeusia and muscle ache/joint pain, on which information was collected at index hospitalization and during follow-up assessments. The analysis considered a time to the resolution of individual and all neurological symptoms. The resulting times were modelled by Weibull regression, assuming mixed-case interval censoring, with sex and age included as covariates. The model results were summarized as cumulative probability functions and age-adjusted and sex-adjusted median times to resolution. We included 6862 hospitalized adults with coronavirus disease 2019, who had follow-up assessments. The median age of the participants was 57 years (39.2% females). Males and females had similar baseline characteristics, except that more males (versus females) were admitted to the intensive care unit (30.5 versus 20.3%) and received mechanical ventilation (17.2 versus 11.8%). Approximately 70% of patients had multiple neurological symptoms at the first follow-up (median = 102 days). Fatigue (49.9%) and myalgia/arthralgia (45.2%) were the most prevalent symptoms of PANSC at the initial follow-up. The reported prevalence in females was generally higher (versus males) for all ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1093/braincomms/fcae036 |
| Availability: |
https://hal.science/hal-04831170; https://hal.science/hal-04831170v1/document; https://hal.science/hal-04831170v1/file/fcae036.pdf; https://doi.org/10.1093/braincomms/fcae036 |
| Rights: |
https://about.hal.science/hal-authorisation-v1/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.260BD89D |
| Database: |
BASE |