| Title: |
Canagliflozin and iron metabolism in the CREDENCE trial |
| Authors: |
Koshino, A; Heerspink, HJL; Jongs, N; Badve, SV; Arnott, C; Neal, B; Jardine, M; Mahaffey, KW; Pollock, C; Perkovic, V; Hansen, MK; Bakker, SJL; Wada, T; Neuen, BL |
| Source: |
urn:ISSN:0931-0509 ; urn:ISSN:1460-2385 ; Nephrology Dialysis Transplantation, 40, 4, 696-706 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2025 |
| Collection: |
UNSW Sydney (The University of New South Wales): UNSWorks |
| Subject Terms: |
32 Biomedical and Clinical Sciences; 3202 Clinical Sciences; Dietary Supplements; Kidney Disease; Clinical Trials and Supportive Activities; Diabetes; Nutrition; Clinical Research; Hematology; Cardiovascular; 6.1 Pharmaceuticals; 5.1 Pharmaceuticals; Renal and urogenital; 3 Good Health and Well Being; Humans; Male; Canagliflozin; Female; Middle Aged; Iron; Renal Insufficiency; Chronic; Aged; Sodium-Glucose Transporter 2 Inhibitors; Diabetes Mellitus; Type 2; Double-Blind Method; Follow-Up Studies; Prognosis; Glomerular Filtration Rate |
| Description: |
Background. Studies in patients with heart failure have indicated that sodium-glucose cotransporter 2 (SGLT2) inhibitors increase iron use and enhance erythropoiesis. In this post hoc analysis of the Canagliflozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) trial, we evaluated the effects of canagliflozin on iron metabolism in patients with chronic kidney disease (CKD) and whether the effects of canagliflozin on hemoglobin and cardiorenal outcomes were modified by iron deficiency. Methods. We measured serum iron, total iron binding capacity (TIBC), transferrin saturation (TSAT) and ferritin at baseline and 12 months. The effects of canagliflozin, relative to placebo, on iron markers were assessed with analysis of covariance. Interactions between baseline iron deficiency, defined as TSAT |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
https://hdl.handle.net/1959.4/104434; https://doi.org/10.1093/ndt/gfae198 |
| DOI: |
10.1093/ndt/gfae198 |
| Availability: |
https://hdl.handle.net/1959.4/104434; https://unsworks.unsw.edu.au/bitstreams/938a192a-8a6c-42ac-9bd6-9005506bb034/download; https://doi.org/10.1093/ndt/gfae198 |
| Rights: |
open access ; https://purl.org/coar/access_right/c_abf2 ; CC BY ; https://creativecommons.org/licenses/by/4.0/ ; free_to_read |
| Accession Number: |
edsbas.2618E8F2 |
| Database: |
BASE |