| Title: |
Posthospitalization COVID-19 cognitive deficits at 1 year are global and associated with elevated brain injury markers and gray matter volume reduction |
| Authors: |
Wood, G.K.; Sargent, B.F.; Ahmad, Z.-U.-A.; Tharmaratnam, K.; Dunai, C.; Egbe, F.N.; Martin, N.H.; Facer, B.; Pendered, S.L.; Rogers, H.C.; Hübel, C.; van Wamelen, D.J.; Bethlehem, R.A.I.; Giunchiglia, V.; Hellyer, P.J.; Trender, W.; Kalsi, G.; Needham, E.; Easton, A.; Jackson, T.A.; Cunningham, C.; Upthegrove, R.; Pollak, T.A.; Hotopf, M.; Solomon, T.; Pett, S.L.; Shaw, P.J.; Wood, N.; Harrison, N.A.; Miller, K.L.; Jezzard, P.; Williams, G.; Duff, E.P.; Williams, S.; Zelaya, F.; Smith, S.M.; Keller, S.; Broome, M.; Kingston, N.; Husain, M.; Vincent, A.; Bradley, J.; Chinnery, P.; Menon, D.K.; Aggleton, J.P.; Nicholson, T.R.; Taylor, J.-P.; David, A.S.; Carson, A.; Bullmore, E.; Breen, G.; Hampshire, A.; Alam, A.M.; Al-Chalabi, A.; Allen, C.M.; Amin, J.; Armour, C.; Baker, M.R.; Barrett, S.; Basu, N.; Batra, R.; Benjamin, L.; Berry, A.; Blackledge, B.; Boardman, S.A.; Breen, D.P.; Breuer, J.; Butler, M.; Castell, H.; Cavanagh, J.; Christmas, D.; Christmas, D.M.; Coleman, J.R.I.; Coles, A.; Collie, C.; Cossette, N.; Cousins, D.; Darby, A.; Davies, N.; Defres, S.; Dodd, K.C.; Dregan, A.; Duff, E.; Ellul, M.A.; Evangelou, N.; Fernandes, P.M.; Francis, R.; Galea, I.; Garjani, A.; George, L.; Glen, K.; Gregory, R.; Griffiths, M.; Grimbly, V.; Grundmann, A.; Gunatilake, S.; Hamid, S.H.M.; Hardwick, M.; Harris, J.D.; Harrison, E.; Harrison, P.J.; Hartmann, M.; Hetherington, C.; Hilton, O.; Hiscox, J.; Hodel, E.M.; Holland, A.E.; Huang, Y.; Hughes, S.; Irani, S.; Jenkins, T.M.; Zvrskovec, J.K.; Kyaw, S.; Lewis, G.; Lilleker, J.B.; Lunn, M.P.; MacIver, C.L.; Madarshahian, D.; Mansoori, P.; Martin, N.; McDonnell, G.; McGlinchey, E.; McKeever, S.; McIlwaine, R.; McIntosh, A.M.; Monssen, D.; Morris, C.M.; Mulholland, C.; Nair, A.; Newcombe, V.; Nicholas, N.; O’Malley, R.; Orazulume, O.; Ostermann, M.; Palmos, A.; Patel, A.; Peacock, S.; Roberts, A.; Rota, S.; Salman, R.A.-S.; Samuel, M.; Sawcer, S.J.; Seed, A.W.; Semple, S.; Shil, R.S.K.; Sieradzki, A.; Singh, B.; Smith, C.J.; Smith, J.; Taams, L.; Tamborska, A.; Thomas, R.H.; Thomson, E.; Underwood, J.; Veenith, T.; Venneri, A.; Wong, S.H.; Zandi, M.S.; Michael, B.D.; Paddick, S.-M.; Leek, E.C. |
| Publisher Information: |
Springer Science and Business Media LLC |
| Publication Year: |
2025 |
| Collection: |
White Rose Research Online (Universities of Leeds, Sheffield & York) |
| Description: |
The spectrum, pathophysiology and recovery trajectory of persistent post-COVID-19 cognitive deficits are unknown, limiting our ability to develop prevention and treatment strategies. We report the 1-year cognitive, serum biomarker and neuroimaging findings from a prospective, national study of cognition in 351 COVID-19 patients who required hospitalization, compared with 2,927 normative matched controls. Cognitive deficits were global, associated with elevated brain injury markers and reduced anterior cingulate cortex volume 1 year after COVID-19. Severity of the initial infective insult, postacute psychiatric symptoms and a history of encephalopathy were associated with the greatest deficits. There was strong concordance between subjective and objective cognitive deficits. Longitudinal follow-up in 106 patients demonstrated a trend toward recovery. Together, these findings support the hypothesis that brain injury in moderate to severe COVID-19 may be immune-mediated, and should guide the development of therapeutic strategies. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| ISSN: |
1078-8956 |
| Relation: |
https://eprints.whiterose.ac.uk/id/eprint/222360/1/s41591-024-03309-8.pdf; Wood, G.K. orcid.org/0000-0001-6098-2331 , Sargent, B.F. orcid.org/0000-0003-2262-7755 , Ahmad, Z.-U.-A. orcid.org/0000-0002-6940-8851 et al. (173 more authors) (2025) Posthospitalization COVID-19 cognitive deficits at 1 year are global and associated with elevated brain injury markers and gray matter volume reduction. Nature Medicine, 31. pp. 245-257. ISSN: 1078-8956 |
| DOI: |
10.1038/s41591-024-03309-8 |
| Availability: |
https://eprints.whiterose.ac.uk/id/eprint/222360/; https://doi.org/10.1038/s41591-024-03309-8 |
| Rights: |
cc_by_4 |
| Accession Number: |
edsbas.26236276 |
| Database: |
BASE |