| Title: |
Spatio-Temporal Regulation of Notch Activation in Asymmetrically Dividing Sensory Organ Precursor Cells in Drosophila melanogaster Epithelium |
| Authors: |
Pinot, Mathieu; Le Borgne, Roland |
| Contributors: |
Institut de Génétique et Développement de Rennes (IGDR); Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes (Biosit : Biologie - Santé - Innovation Technologique); This research was funded in part by a research grant from the Agence Nationale de la Recherche (ANR) programme PRC Vie, santé et bien être ACTriCE (ANR-20-CE13-0015), and Fondation ARC (PJA 20191209388).; ANR-20-CE13-0015,ACTRICE,Contribution des Jonctions Tricellulaires dans la Mécanique Epithéliale(2020) |
| Source: |
ISSN: 2073-4409 ; Cells ; https://hal.science/hal-04649775 ; Cells, 2024, 13 (13), pp.1133. ⟨10.3390/cells13131133⟩. |
| Publisher Information: |
HAL CCSD; MDPI |
| Publication Year: |
2024 |
| Collection: |
Université de Rennes 1: Publications scientifiques (HAL) |
| Subject Terms: |
Drosophila melanogaster; Notch signaling; asymmetric cell division; cell fate determinants; cell polarity; epithelial cells; [SDV]Life Sciences [q-bio] |
| Description: |
International audience ; The Notch communication pathway, discovered in Drosophila over 100 years ago, regulates a wide range of intra-lineage decisions in metazoans. The division of the Drosophila mechanosensory organ precursor is the archetype of asymmetric cell division in which differential Notch activation takes place at cytokinesis. Here, we review the molecular mechanisms by which epithelial cell polarity, cell cycle and intracellular trafficking participate in controlling the directionality, subcellular localization and temporality of mechanosensitive Notch receptor activation in cytokinesis. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/38994985; PUBMED: 38994985 |
| DOI: |
10.3390/cells13131133 |
| Availability: |
https://hal.science/hal-04649775; https://hal.science/hal-04649775v1/document; https://hal.science/hal-04649775v1/file/cells-13-01133.pdf; https://doi.org/10.3390/cells13131133 |
| Rights: |
http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.2657BC01 |
| Database: |
BASE |