| Title: |
Resting-state functional MRI demonstrates brain network reorganization in neuromyelitis optica spectrum disorder (NMOSD) |
| Authors: |
Bigaut, K. (Kévin); Achard, S. (Sophie); Hemmert, C. (Céline); Baloglu, S. (Seyyid); Kremer, L. (Laurent); Collongues, N. (Nicolas); De Seze, J. (Jerome); Kremer, S. (Stephane); De Vico Fallani, F. (Fabrizio) (editor) |
| Publication Year: |
2019 |
| Subject Terms: |
Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] |
| Description: |
BACKGROUND: The relation between brain functional connectivity of patients with neuromyelitis optica spectrum disorder (NMOSD) and the degree of disability remains unclear. OBJECTIVE: Compare brain functional connectivity of patients with NMOSD to healthy subjects in resting-state functional MRI (rs-fMRI). METHODS: We compared the rs-fMRI connectivity in 12 NMOSD patients with 20 healthy subjects matched for age and sex. Graph theory analysis was used to quantify the role of each node using a set of metrics: degree, global efficiency, clustering and modularity. To summarize the abnormal connectivity profile of brain regions in patients compared to healthy subjects, we defined a hub disruption index κ. RESULTS: Concerning the global organization of networks in NMOSD, a small-world topology was preserved without significant modification concerning all average metrics. However, visual networks and the sensorimotor network showed decreased connectivity with high interindividual variability. The hub disruption index κ was correlated to the Expanded Disability Status Scale (EDSS). CONCLUSION: These results demonstrate a correlation between disability according to the EDSS and neuronal reorganization using the rs-fMRI graph methodology. The conservation of a normal global topological structure despite local modifications in functional connectivity seems to show brain plasticity in response to the disability. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1371/journal.pone.0211465 |
| Availability: |
https://doi.org/10.1371/journal.pone.0211465 |
| Rights: |
Paternité [CC] [BY] ; info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.26827661 |
| Database: |
BASE |