| Title: |
Hepatoprotective activity of the wild carrot chloroform-based fraction against CCl4-induced liver toxicity in mice |
| Authors: |
Shebaby, W.; El-Sibai, M.; Mroueh, M.; Bodman-Smith, K.; Taleb, R.; Daher, C. |
| Publication Year: |
2018 |
| Collection: |
Lebanese American University Repository (LAUR) |
| Description: |
The liver plays a major role in detoxifying and clearing xenobiotics that may lead to liver damage and hepatic dysfunction. The present study was carried out to evaluate the hepatoprotective activities of the chloroform-based fraction of wild carrot (Daucus carota L. ssp. carota; Apiacae) on CCl4-induced liver damage in BALB/c mice. Liver damage was induced by intraperitoneal injection of CCl4 at a dose of 1 ml/kg body weight. Animals were treated with different doses of the extract (50, 100 and 200 mg/kg body weight). Serum and liver homogenate supernatants were analyzed for marker enzymes aspartate transaminase (AST), alanine transaminase (ALT), catalase (CAT), superoxide dismutase (SOD) and glutathione S-transferase (GST) activities. Pretreated groups with chloroform-based fraction reduced significantly the serum levels of AST and ALT. It also reversed the CCl4-induced decrease in SOD, CAT and GST levels thereby reducing significantly hepatic damage. HPLC analysis revealed that the chloroform-based fraction was rich in polyphenolic compounds such as luteolin, kaempferol, apigenin and quercetin, which could be partially responsible for the hepatoprotective effect. The current results suggest that chloroform-based fraction possess strong hepatoprotective activity against CCl4 induced liver damage at all doses used ; Published ; N/A |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
Planta Medica; http://hdl.handle.net/10725/7425 |
| DOI: |
10.1055/s-0034-1395009 |
| Availability: |
http://hdl.handle.net/10725/7425; https://doi.org/10.1055/s-0034-1395009; http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php; https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0034-1395009 |
| Accession Number: |
edsbas.26C0B336 |
| Database: |
BASE |