| Title: |
Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2 |
| Authors: |
Collier, Dami, A; Ferreira, Isabella, a T M; Kotagiri, Prasanti; Datir, Rawlings, P; Lim, Eleanor, Y; Touizer, Emma; Meng, Bo; Abdullahi, Adam; Baker, Stephen; Dougan, Gordon; Hess, Christoph; Kingston, Nathalie; Lehner, Paul, J; Lyons, Paul, A; Matheson, Nicholas, J; Owehand, Willem, H; Saunders, Caroline; Summers, Charlotte; Thaventhiran, James, E D; Toshner, Mark; Weekes, Michael, P; Maxwell, Patrick; Shaw, Ashley; Bucke, Ashlea; Calder, Jo; Canna, Laura; Domingo, Jason; Elmer, Anne; Fuller, Stewart; Harris, Julie; Hewitt, Sarah; Kennet, Jane; Jose, Sherly; Kourampa, Jenny; Meadows, Anne; O’brien, Criona; Price, Jane; Publico, Cherry; Rastall, Rebecca; Ribeiro, Carla; Rowlands, Jane; Ruffolo, Valentina; Tordesillas, Hugo; Bullman, Ben; Dunmore, Benjamin, J; Fawke, Stuart; Gräf, Stefan; Hodgson, Josh; Huang, Christopher; Hunter, Kelvin; Jones, Emma; Legchenko, Ekaterina; Matara, Cecilia; Martin, Jennifer; Mescia, Federica; O’donnell, Ciara; Pointon, Linda; Pond, Nicole; Shih, Joy; Sutcliffe, Rachel; Tilly, Tobias; Treacy, Carmen; Tong, Zhen; Wood, Jennifer; Wylot, Marta; Bergamaschi, Laura; Betancourt, Ariana; Bower, Georgie; Cossetti, Chiara; de Sa, Aloka; Epping, Madeline; Gleadall, Nick; Grenfell, Richard; Hinch, Andrew; Huhn, Oisin; Jackson, Sarah; Jarvis, Isobel; Krishna, Ben; Lewis, Daniel; Marsden, Joe; Nice, Francesca; Okecha, Georgina; Omarjee, Ommar; Perera, Marianne; Potts, Martin; Richoz, Nathan; Romashova, Veronika; Yarkoni, Natalia, Savinykh; Sharma, Rahul; Stefanucci, Luca; Stephens, Jonathan; Strezlecki, Mateusz; Turner, Lori; D. D. de Bie, Eckart, M; Bunclark, Katherine; Josipovic, Masa; Mackay, Michael; Michael, Alice; Rossi, Sabrina; Selvan, Mayurun; Spencer, Sarah; Yong, Cissy; Ansaripour, Ali; Mwaura, Lucy; Patterson, Caroline; Polwarth, Gary; Polgarova, Petra; Di Stefano, Giovanni; Fahey, Codie; Michel, Rachel; Bong, Sze-How; Coudert, Jerome, D; Holmes, Elaine; Allison, John; Butcher, Helen; Caputo, Daniela; Clapham-Riley, Debbie; Dewhurst, Eleanor; Furlong, Anita; Graves, Barbara; Gray, Jennifer; Ivers, Tasmin; Kasanicki, Mary; Le Gresley, Emma; Linger, Rachel; Meloy, Sarah; Muldoon, Francesca; Ovington, Nigel; Papadia, Sofia; Phelan, Isabel; Stark, Hannah; Stirrups, Kathleen, E; Townsend, Paul; Walker, Neil; Webster, Jennifer; Smith, Kenneth, G C; Bradley, John, R; Ceron-Gutierrez, Lourdes; Cortes-Acevedo, Paulina; Barcenas-Morales, Gabriela; Linterman, Michelle, A; Mccoy, Laura, E; Davis, Chris; Thomson, Emma; Mckinney, Eoin; Doffinger, Rainer; Wills, Mark; Gupta, Ravindra, K |
| Contributors: |
University College London UCL (UCL); Cambridge Institute of Therapeutic Immunology & Infectious Disease; Centre Européen de Réalité Virtuelle (CERV); École Nationale d'Ingénieurs de Brest (ENIB); Université de Brest (UBO EPE)-Institut National Polytechnique de Bretagne (Bretagne INP)-Université de Brest (UBO EPE)-Institut National Polytechnique de Bretagne (Bretagne INP); Oxford University Clinical Research Unit Ho Chi Minh City (OUCRU); The Wellcome Trust Sanger Institute Cambridge; Récifes-CIREL; Centre Interuniversitaire de Recherche en Education de Lille - ULR 4354 (CIREL); Université de Lille-Université de Lille; École, mutations, apprentissages (EMA); CY Cergy Paris Université (CY); Cardiff School of Engineering; Cardiff University; PepsiCo; Lucozade Ribena Suntory Ltd; Partenaires INRAE; University of Cambridge Cambridge, UK (CAM); Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University; The University of Notre Dame Australia (UNDA) |
| Source: |
ISSN: 0028-0836. |
| Publisher Information: |
CCSD; Nature Publishing Group |
| Publication Year: |
2021 |
| Collection: |
Université Paris Seine: ComUE (HAL) |
| Subject Terms: |
[SDV]Life Sciences [q-bio] |
| Description: |
International audience ; Although two-dose mRNA vaccination provides excellent protection against SARS-CoV-2, there is little information about vaccine efficacy against variants of concern (VOC) in individuals above eighty years of age1. Here we analysed immune responses following vaccination with the BNT162b2 mRNA vaccine2 in elderly participants and younger healthcare workers. Serum neutralization and levels of binding IgG or IgA after the first vaccine dose were lower in older individuals, with a marked drop in participants over eighty years old. Sera from participants above eighty showed lower neutralization potency against the B.1.1.7 (Alpha), B.1.351 (Beta) and P.1. (Gamma) VOC than against the wild-type virus and were more likely to lack any neutralization against VOC following the first dose. However, following the second dose, neutralization against VOC was detectable regardless of age. The frequency of SARS-CoV-2 spike-specific memory B cells was higher in elderly responders (whose serum showed neutralization activity) than in non-responders after the first dose. Elderly participants showed a clear reduction in somatic hypermutation of class-switched cells. The production of interferon-γ and interleukin-2 by SARS-CoV-2 spike-specific T cells was lower in older participants, and both cytokines were secreted primarily by CD4 T cells. We conclude that the elderly are a high-risk population and that specific measures to boost vaccine responses in this population are warranted, particularly where variants of concern are circulating. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1038/s41586-021-03739-1 |
| Availability: |
https://hal.science/hal-04871050; https://hal.science/hal-04871050v1/document; https://hal.science/hal-04871050v1/file/s41586-021-03739-1.pdf; https://doi.org/10.1038/s41586-021-03739-1 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.2746BC13 |
| Database: |
BASE |