| Title: |
Catastrophic antiphospholipid syndrome mimicking a malignant pancreatic tumour – a case report |
| Authors: |
van Wissen, S; Bastiaansen, BAJ; Stroobants, AK; van den Dool, EJ; Idu, MM; Levi, M; Stroes, ESG |
| Source: |
Lupus ; volume 17, issue 6, page 586-590 ; ISSN 0961-2033 1477-0962 |
| Publisher Information: |
SAGE Publications |
| Publication Year: |
2008 |
| Description: |
The catastrophic antiphospholipid syndrome is characterised by rapid onset thromboses, often resistant to conventional anticoagulant treatment, and resulting in life threatening multiple organ dysfunction. The diagnosis of catastrophic antiphospholipid syndrome may be difficult, predominantly due to its frequently atypical presentation. We report a case of a 35-year-old female who presented with a pancreatic tumour and extensive thromboses. Following a storm of ischemic events due to thrombotic occlusions in spite of therapeutic heparin dose, the suspicion of catastrophic antiphospholipid syndrome emerged. The patient was successfully treated with anticoagulants, immunuglobulins, plasmapheresis and rituximab. The present report shows that the use of the diluted Russell’s viper venom time can be helpful in providing additional information on the lupus anticoagulans antibody status, allowing careful monitoring of lupus anticoagulans conversion and hence response to therapy. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1177/0961203307087406 |
| Availability: |
https://doi.org/10.1177/0961203307087406; https://journals.sagepub.com/doi/pdf/10.1177/0961203307087406 |
| Rights: |
https://journals.sagepub.com/page/policies/text-and-data-mining-license |
| Accession Number: |
edsbas.275D5C48 |
| Database: |
BASE |