| Title: |
The Role of Sex and Depression on Cognitive Impairment Risk in a Longitudinal Study of Older Adults |
| Authors: |
Rutter, Lauren; Hamilton, Lucas; Wilson, Skylar; Krendl, Anne; Perry, Brea |
| Source: |
Innovation in Aging ; volume 9, issue Supplement_2 ; ISSN 2399-5300 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2025 |
| Description: |
Depression and biological sex independently influence Alzheimer’s disease and related disorders (ADRD) risk, yet their interaction is underexplored. This study examines whether depression differentially impacts impairment risk for men and women in a large, longitudinal sample. Data were obtained from the National Alzheimer’s Disease Coordinating Center Uniform Data Set (N = 26,362, 59.3% women). Depression status was determined using the Geriatric Depression Scale (GDS≥5), and impairment was defined as progression to mild cognitive impairment or dementia. Impairment status was decided by either a consensus panel or a single physician. Cox proportional-hazards models tested the effects of depression, sex, and their interaction on impairment risk, controlling for age and APOEε4 status. Results showed significant main effects of depression, sex, age, and APOEε4 on impairment risk, and a significant interaction of depression and sex (p |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1093/geroni/igaf122.102 |
| Availability: |
https://doi.org/10.1093/geroni/igaf122.102; https://academic.oup.com/innovateage/article-pdf/9/Supplement_2/igaf122.102/66231356/igaf122.102.pdf |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.275DA91B |
| Database: |
BASE |