| Title: |
Diagnostic value of anti-Müllerian hormone combined with androgen-levels in Chinese patients with polycystic ovary syndrome |
| Authors: |
Lingling Jiang; Xiangyan Ruan; Yanqiu Li; Muqing Gu; Jiaojiao Cheng; Yuejiao Wang; Yu Yang; Che Xu; Zhikun Wang; Lili Liu; Alfred O. Mueck |
| Source: |
Gynecological Endocrinology, Vol 39, Iss 1 (2023) |
| Publisher Information: |
Taylor & Francis Group |
| Publication Year: |
2023 |
| Collection: |
Directory of Open Access Journals: DOAJ Articles |
| Subject Terms: |
Polycystic ovary syndrome; anti-müllerian hormone; cutoff; androgen; free testosterone; Gynecology and obstetrics; RG1-991; Diseases of the endocrine glands. Clinical endocrinology; RC648-665 |
| Description: |
Objective To establish a cutoff level of AMH which could help for the diagnosis of PCOS, to investigate the predictive value of AMH combined with androgens in Chinese women to diagnose PCOS.Materials and Methods This is a prospective case control study, 550 women recruited (aged 20–40 years), in which 450 PCOS women recruited according to the Rotterdam criteria and 100 non-PCOS women in the control group were from the women for the pregnancy preparation examination. AMH were measured by the Elecsys AMH Plus immunoassay. Androgens and other sex hormone were measured. The validity of AMH toward the diagnosis of PCOS, or AMH combined with total testosterone, free testosterone, bioavailable testosterone and androstenedione was estimated by receiver operating characteristic (ROC)curves, and correlations between paired variables was estimated by Spearman’s rank correlation coefficient.Results The cutoff value of AMH in Chinese reproductive-age women with PCOS is 4.64 ng/mL, AUC under the curve is 0.938, with 81.6% sensitivity, and 92.0% specificity. Total testosterone, free testosterone, bioactive testosterone, and androstenedione are significantly higher in women with PCOS of reproductive age than in controls. The combination of AMH and free testosterone resulted in a higher AUC of 94.8%, with higher sensitivity (86.1%) and excellent specificity (90.3%) for the prediction of PCOS.Conclusion The Elecsys AMH Plus immunoassay, with a cutoff of 4.64 ng/mL, is a robust method for identifying PCOM to aid in PCOS diagnosis. The combination of AMH and free testosterone resulted in a higher AUC of 94.8% for the diagnose of PCOS. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://doaj.org/toc/0951-3590; https://doaj.org/toc/1473-0766; https://doaj.org/article/60067b042206442d9a0fd8e94ddc0b81 |
| DOI: |
10.1080/09513590.2023.2206927 |
| Availability: |
https://doi.org/10.1080/09513590.2023.2206927; https://doaj.org/article/60067b042206442d9a0fd8e94ddc0b81 |
| Accession Number: |
edsbas.277668C1 |
| Database: |
BASE |