| Title: |
Subcutaneous Abatacept in New Onset Type 1 Diabetes:Clinical and Immunological Effects |
| Authors: |
Jerram, Samuel T.; Yang, Jennie H.M.; Williams, Evangelia; Domingo-Vila, Clara; Liu, Yuk Fun; Peakman, Mark; Leslie, R. David; Tree, Timothy |
| Source: |
Jerram, S T, Yang, J H M, Williams, E, Domingo-Vila, C, Liu, Y F, Peakman, M, Leslie, R D & Tree, T 2025, 'Subcutaneous Abatacept in New Onset Type 1 Diabetes : Clinical and Immunological Effects', Diabetes/Metabolism Research and Reviews, vol. 41, no. 6, e70074. https://doi.org/10.1002/dmrr.70074 |
| Publication Year: |
2025 |
| Collection: |
King's College, London: Research Portal |
| Subject Terms: |
Abatacept; diabetes; immunotherapy |
| Description: |
Abatacept is a CTLA4-Ig fusion protein that blocks CD80/CD86-dependent T-cell co-stimulation. When administered, Abatacept limits, to a variable degree, loss of stimulated C-peptide secretion in patients with newly-diagnosed type 1 diabetes (T1D), while reducing both circulating memory CD4+ T-cells and T follicular helper (Tfh) cells; however, its precise mechanism of action is not known. To investigate this effect, we studied 12 patients, using multi-parameter flow cytometry, who each self-administered Abatacept in subcutaneous formulation for 6 months within 100 days of diagnosis. Abatacept treatment impacted the CD4+ T cell memory compartment, inducing a reduction in T-effector cells across both conventional (Tconv) and regulatory (Treg) sub-populations. A reduction in activated Tfh cells (CXCR5+PD1+ICOS+), previously described with intravenous therapy, was replicated and extended. An integrated baseline immunological phenotype predicted Abatacept-induced preservation of C-peptide. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
1520-7552 |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/40790833; info:eu-repo/semantics/altIdentifier/pissn/1520-7552 |
| DOI: |
10.1002/dmrr.70074 |
| Availability: |
https://kclpure.kcl.ac.uk/portal/en/publications/77473217-f86b-4a4d-bb3d-52fb7ca25d86; https://doi.org/10.1002/dmrr.70074; https://kclpure.kcl.ac.uk/ws/files/354186948/Diabetes_Metabolism_Res_-_2025_-_Jerram_-_Subcutaneous_Abatacept_in_New_Onset_Type_1_Diabetes_Clinical_and_Immunological.pdf; https://www.scopus.com/pages/publications/105012960391 |
| Rights: |
info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.27974480 |
| Database: |
BASE |