| Title: |
The use of core needle biopsy as first-line in diagnosis of thyroid nodules reduces false negative and inconclusive data reported by fine-needle aspiration. |
| Authors: |
Trimboli P; Nasrollah N; Guidobaldi L; Taccogna S; Cicciarella Modica DD; Amendola S; Giovanella L; Crescenzi A.; ROMANELLI, Francesco; LENZI, Andrea; NIGRI, Giuseppe; CENTANNI, Marco; VALABREGA, Stefano |
| Contributors: |
Trimboli, P; Nasrollah, N; Guidobaldi, L; Taccogna, S; Cicciarella Modica, Dd; Amendola, S; Romanelli, Francesco; Lenzi, Andrea; Nigri, Giuseppe; Centanni, Marco; Giovanella, L; Valabrega, Stefano; Crescenzi, A. |
| Publication Year: |
2014 |
| Collection: |
Sapienza Università di Roma: CINECA IRIS |
| Subject Terms: |
Thyroid cancer; Core needle biopsy (CNB); Ultrasonography; Fine- needle aspiration (FNA) |
| Description: |
BACKGROUND: The reported reliability of core needle biopsy (CNB) is high in assessing thyroid nodules after inconclusive fine-needle aspiration (FNA) attempts. However, first-line use of CNB for nodules considered at risk by ultrasonography (US) has yet to be studied. The aim of this study were: 1) to evaluate the potential merit of using CNB first-line instead of conventional FNA in thyroid nodules with suspicious ultrasonographic features; 2) to compare CNB and FNA as a first-line diagnostic procedure in thyroid lesions at higher risk of cancer. METHODS: Seventy-seven patients with a suspicious-appearing, recently discovered solid thyroid nodule were initially enrolled as study participants. No patients had undergone prior thyroid fine-needle aspiration/biopsy. Based on study design, all patients were proposed to undergo CNB as first-line diagnostic aspiration, while those patients refusing to do so underwent conventional FNA. RESULTS: Five patients refused the study, and a total of 31 and 41 thyroid nodules were subjected to CNB and FNA, respectively. At follow-up, the overall rate of malignancy was of 80% (CNB, 77%; FNA, 83%). However, the diagnostic accuracy of CNB (97%) was significantly (P < 0.05) higher than that of FNA (78%). In one benign lesion, CNB was inconclusive. Four (12%) of the 34 cancers of the FNA group were not initially diagnosed because of false negative (N = 1), indeterminate (N = 2) or not adequate (N = 1) samples. CONCLUSIONS: CNB can reduce the false negative and inconclusive results of conventional FNA and should be considered a first-line method in assessing solid thyroid nodules at high risk of malignancy. |
| Document Type: |
article in journal/newspaper |
| File Description: |
ELETTRONICO |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/24661377; info:eu-repo/semantics/altIdentifier/wos/WOS:000335354400001; volume:12; firstpage:61; lastpage:67; numberofpages:7; journal:WORLD JOURNAL OF SURGICAL ONCOLOGY; http://hdl.handle.net/11573/626596 |
| DOI: |
10.1186/1477-7819-12-61 |
| Availability: |
http://hdl.handle.net/11573/626596; https://doi.org/10.1186/1477-7819-12-61 |
| Accession Number: |
edsbas.28921739 |
| Database: |
BASE |