| Title: |
Murine Leukemia Virus Exploits Innate Sensing by Toll-Like Receptor 7 in B-1 Cells To Establish Infection and Locally Spread in Mice |
| Authors: |
Pi, Ruoxi; Iwasaki, Akiko; Sewald, Xaver; Mothes, Walther; Uchil, Pradeep D. |
| Contributors: |
Simon, Viviana; HHS | NIH | National Cancer Institute; HHS | NIH | National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute |
| Source: |
Journal of Virology ; volume 93, issue 21 ; ISSN 0022-538X 1098-5514 |
| Publisher Information: |
American Society for Microbiology |
| Publication Year: |
2019 |
| Description: |
Viruses establish infection in hosts by targeting highly permissive cell types. The retrovirus Friend murine leukemia virus (FrMLV) infects a subtype of B cells called B-1 cells that permit robust virus replication. The reason for their susceptibility had remained unknown. We found that innate sensing of incoming virus and the ensuing type I interferon response within B-1 cells are responsible for their observed susceptibility. Our data provide insights into how retroviruses coevolved with the host to co-opt innate immune sensing pathways designed to fight virus infections for establishing infection. Understanding early events in viral spread can inform antiviral intervention strategies that prevent the colonization of a host. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1128/jvi.00930-19 |
| DOI: |
10.1128/JVI.00930-19 |
| Availability: |
https://doi.org/10.1128/jvi.00930-19; https://journals.asm.org/doi/pdf/10.1128/JVI.00930-19 |
| Rights: |
https://journals.asm.org/non-commercial-tdm-license |
| Accession Number: |
edsbas.28AC6012 |
| Database: |
BASE |