| Title: |
Post-Hospitalisation COVID-19 Rehabilitation (PHOSP-R): a randomised controlled trial of exercise-based rehabilitation |
| Authors: |
Daynes, Enya; Evans, Rachael A; Greening, Neil J; Bishop, Nicolette C; Yates, Thomas; Lozano-Rojas, Daniel; Ntotsis, Kimon; Richardson, Matthew; Baldwin, Molly M; Hamrouni, Malik; Hume, Emily; McAuley, Hamish; Mills, George; Megaritis, Dimitrios; Roberts, Matthew; Bolton, Charlotte E; Chalmers, James D; Chalder, Trudie; Docherty, Annemarie B; Elneima, Omer; Harrison, Ewen M; Harris, Victoria C; Ho, Ling p; Horsley, Alex; Houchen-Wolloff, Linzy; Leavy, Olivia C; Marks, Michael; Poinasamy, Krishna; Quint, Jennifer K; Raman, Betty; Saunders, Ruth M; Shikotra, Aarti; Singapuri, Amisha; Sereno, Marco; Terry, Sarah; Wain, Louise V; Man, William D-C; Echevarria, Carlos; Vogiatzis, Ioannis; Brightling, Christopher; Singh, Sally J |
| Publisher Information: |
European Respiratory Society |
| Publication Year: |
2025 |
| Collection: |
University of Nottingham: Repository@Nottingham |
| Description: |
ObjectivePost-COVID syndrome involves prolonged symptoms with multisystem and functional impairment lasting ≥12 weeks after acute coronavirus disease 2019 (COVID-19). We aimed to determine the efficacy of exercise-based rehabilitation interventions, either face-to-face or remote, compared to usual care in individuals experiencing post-COVID syndrome following a hospitalisation with acute COVID-19.DesignThis single-blind randomised controlled trial compared two exercise-based rehabilitation interventions (face-to-face or remote) to usual care in participants with post-COVID syndrome following a hospitalisation. The interventions were either a face-to-face or remote 8-week programme of individually prescribed exercise and education. The primary outcome was the change in Incremental Shuttle Walking Test (ISWT) following 8 weeks of intervention (either face-to-face or remote) compared to usual care. Other secondary outcomes were measured including health-related quality of life (HRQoL), and exploratory outcomes included lymphocyte immunotyping.Results181 participants (55% male, mean±sd age 59±12 years, length of hospital stay 12±19 days) were randomised. There was an improvement in the ISWT distance following face-to-face rehabilitation (mean 52 m, 95% CI 19–85 m; p=0.002) and remote rehabilitation (mean 34 m, 95% CI 1–66 m; p=0.047) compared to usual care alone. There were no differences between groups for HRQoL self-reported symptoms. Analysis of immune markers revealed significant increases in naïve and memory CD8+ T-cells following face-to-face rehabilitation versus usual care alone (p |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://nottingham-repository.worktribe.com/output/45599598; European Respiratory Journal; Volume 65; Issue 5 |
| DOI: |
10.1183/13993003.02152-2024 |
| Availability: |
https://doi.org/10.1183/13993003.02152-2024; https://nottingham-repository.worktribe.com/file/45599598/1/Post-Hospitalisation%20COVID-19%20Rehabilitation%20%28PHOSP-R%29%3A%20a%20randomised%20controlled%20trial%20of%20exercise-based%20rehabilitation; https://nottingham-repository.worktribe.com/output/45599598 |
| Rights: |
openAccess ; https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.28B41ECC |
| Database: |
BASE |