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Apixaban versus warfarin in patients with atrial fibrillation

Title:	Apixaban versus warfarin in patients with atrial fibrillation
Authors:	Granger C. B.; Alexander J. H.; McMurray J. J. V.; Lopes R. D.; Hylek E. M.; Hanna M.; Al-Khalidi H. R.; Ansell J.; Atar D.; Avezum A.; Bahit M. C.; Diaz R.; Easton J. D.; Ezekowitz J. A.; Flaker G.; Garcia D.; Geraldes M.; Gersh B. J.; Golitsyn S.; Goto S.; Hermosillo A. G.; Hohnloser S. H.; Horowitz J.; Mohan P.; Jansky P.; Lewis B. S.; Lopez-Sendon J. L.; Pais P.; Parkhomenko A.; Verheugt F. W. A.; Zhu J.; Wallentin L. Collaborators ARISTOTLE Committees and Investigators: Christopher B Granger; Lars Wallentin; John H Alexander; Jack Ansell; Rafael Diaz; J Donald Easton; Bernard J Gersh; Michael Hanna; John Horowitz; Elaine M Hylek; John J V McMurray; Puneet Mohan; Freek W A Verheugt; M Cecilia Bahit; Philip Aylward; John Amerena; Kurt Huber; Jozef Bartunek; Alvaro Avezum; Justin A Ezekowitz; Paul Dorian; Fernando Lanas; Liu Lisheng; Jun Zhu; Daniel Isaza; Petr Jansky; Steen Husted; Veli Pekka Harjola; Philippe Gabriel Steg; Stefan H Hohnloser; Matyas Keltai; Prem Pais; Denis Xavier; Basil S Lewis; Raffaele De Caterina; Shinya Goto; Antonio G Hermosillo; Antonio M W Alings; Dan Atar; Luis Segura; Witold Ruzyllo; Dragos Vinereanu; Sergei Varshavsky; Sergey Golitsyn; Byung-Hee Oh; Patrick Commerford; Jose Luis Lopez-Sendon; Marten Rosenquist; Cetin Erol; Alexander Parkhomenko; Greg Flaker; David Garcia; Marc A Pfeffer; Hans-Christoph Diener; Aldo Maggioni; Stuart Pocock; Jean-Lucien Rouleau; George Wyse; Lisa Hatch; Missy Banks; Allison Handler; Hongqiu Yang; Jyotsna Garg; Keven Griffith; Andrew Burr; Tony Dremsizov; Joan Vidal; Sherri Hinton; Lorraine Rossi; Fred Fiedorek; Sunil Nepal; Robert Croop; Anne Delvaux; Susan Mullin; Natalie Arotsky; Eva Nemeth; Arnaud Bastien; Robert Wolf; Neville Jackson; Rogelio Braceras; Sana Al-Khatib; Renato D Lopes; Claes Held; Cheryl Bushnell; Andreas Terent; Sergio Leonardi; Sumeet Subherwal; Zubin Eapen; John Vavalle; Ali Zomorodi; Bradley Kolls; Jeffrey Berger; Jennifer Vergara; Dipen Parikh; Shams Zia; Greg Stashenko; Carlo Lombardi; Robin Matthews; Emil Hagstrom; Axel Akerblom; Christoph Varenhorst; Shala Ghaderi Berntsson; Anna Stenborg; Erik Lundstrom; Helio Guimaraes; Uri Flato; Salete Nacif; Pedro Barros; Leandro Echenique; Patricia Rodrigues; Luciana Armaganijan; Antonio Carlos Lopes; Alvaro Albrecht; M Vico; I Mackinnon; D Vogel; A Gabito; A Cassettari; C Zaidman; O Montaña; A Hrabar; H Jure; H Lastiri; C Poy; A Caccavo; C Cuneo; H Colombo; F Rolandi; A Hershson; M Garrido; A Sanchez; M L Bruno; D Piskorz; J Cuadrado; E Hasbani; J Serra; L Cartasegna; P Schygiel; C Muratore; J Marino; M I Sosa Liprandi; R A Guerrero; H Ramos; D Mercado; L Guzman; C Beneitez; J Estepo; R Torrijos; E Retyk; N Vita; H Luciardi; M Casey; S Orlando; M B Labarta; D Santos; J Amerena; P Purnell; J Horowitz; H Salem; A Liu; L Zimmet; S Roger; F de Looze; R Lehman; B Jackson; D Ashby; W Heddle; J Rogers; D Brieger; P Martin; D Cross; D Walters; J Waites; J Counsell; A Lowy; K Huber; F Stockenhuber; B Pieske; H Striekwold; B Wollaert; H Nachtergaele; J Vijgen; D El Allaf; G Mairesse; G Boxho; P P De Deyn; M Vanderheyden; O Semeraro; P Desfontaines; J Leroy; F Provenier; B Bruneel; M Vrolix; A Peeters; O Deceuninck; J F Saraiva; G Reis; P Rossi; S Zimmermann; J Jaber; R Botelho; E Manenti; J Jorge; L Maia; P Leães; F Villaça Guimaraes Filho; M Fichino; A De Paola; C Kaoru Indio do Brasil; D Albuquerque; L Bodanese; L Matsubara; R Mourilhe Rocha; P Genta; Z Meneghelo; L Oliveira; A Lorga Filho; B Garbelini Jr; G Oliveira; M Teixeira; D Precoma; E Pelloso; A Muniz; M C Valéria Braile; R Ueda; A Rabelo Alves Jr; P Pimentel Filho; L Zimerman; M Coutinho; J Silveira; H Reis; D Moreira; M Paiva; J L Aziz; J Gois; O Dutra; L Yao; G Syan; B Coutu; R Chehayeb; G Sabe-Affaki; C Fortin; D Borts; R Bhargava; D Fell; J Cha; A Pandey; P Boucher; E Sabbah; P Ma; P Talbot; D Spence; A Wade; M Green; J Berlingieri; S Vizel; Y K Chan; M Blostein; M Talajic; L Sterns; F Grondin; T Hruczkowski; R Labonte; M O'Mahony; D Rupka; I Mangat; A Dowell; A Kelly; F St Maurice; S Henein; K Saunders; B Lasko; M Sami; R MacKinnon; Q Rizvi; D O'Keefe; J Ricci; B Gervais; R Hart; S Bose; S Nawaz; S Connors; L Winkler; M Boileau; J Healey; R Collette; T Rebane; B Ramjattan; R Senior; R Therrien; P Wells; C Raffo; J Cobos; S Potthoff; B Stockins; C Pincetti; R Corbalan; M Vejar; W Li; S Zhao; X Chen; S Wu; H Tan; P Qu; X Jiang; M Wei; X Yang; J Li; S Ma; S Gu; Q Y Dai; L Li; B Yu; Y Yin; N Wang; L Gao; S X Zhou; J A Wang; Z Q Li; F Bai; F Zhang; G Lu; Y Chen; Y Zhang; D Jiang; W Zonggui; H Li; K Cao; Q Lu; T Hu; X Wang; R Botero; A Reyes; N Jaramillo; M Urina; S Velez; E Gomez; L Pava; D Isaza; M Dunaj; M Hudcovic; O Jerabek; R Brat; J Spinar; V Dedek; E Zidkova; I Podpera; M Cech; K Gorican; M Micko; M Stribrna; L Frost; C Torp-Pedersen; C Toftager Larsen; C Tuxen; O May; K E Pedersen; G Jensen; T Nielsen; O Nyvad; S Husted; M Gilså Hansen; K Egstrup; J Lomholdt; K Skagen; T Joen Jakobsen; M Olsen; P Grande; J Melin; M Tynni; V P Harjola; J Strand; H Parikka; T Jääskeläinen; J L Corbelli; P Gosse; A Mirode; J Mansourati; G Lavabre; P Defaye; P G Steg; G Kahrmann; T Horacek; A Bauer; S Spitzer; M Schlegl; B Winkelmann; H F Vöhringer; G Stenzel; W Haverkamp; J Harenberg; M Schumacher; J Wunderlich; M Natour; W Rieker; S Gass; J Brachmann; J Jung; H Poppert; R Häge; L Lickfett; R Schoeller; L Goedel-Meinen; A Utech; M Buerke; M Maschke; R Haberl; E von Hodenberg; B Griewing; F Schlachetzki; H Hamer; T Hoch; M Zabel; R Jordan; F Stögbauer; A Hetzel; C Weimar; P Schauerte; D Fischer; A Mügge; A Bittersohl; K Lee; C Yu; F Lakatos; A Vértes; A Kovács; J Takács; A Pálinkás; J Bakai; A Papp; Á Illés; J Tomcsányi; I Szakál; Z László; A Katona; L Jobbágy; K Keltai; C Dézsi; G Lupkovics; A Cziraki; A Mohácsi; K Simon; S Gupta; D Agarwal; M Fulwani; A Naik; A Nambiar; N Chidambaram; B Srinivasasastry; J Joseph; M Padinhare; P Khanna; P Grant; J Arneja; M Gadkari; N Garg; R B Pothineni; S Sathe; S Ramesh; B Malipeddi; A Bharani; H B Gowdappa; V S Prakash; A Dharmadhikari; S Bhandari; N Desai; S Banerjee; N Ghaisas; B Ramagiri; S Sinha; G Gojanur; J Duggal; V Jain; S Dani; P Singh; V Srikanthan; V K Puri; R Gopal; S Viskin; M Shochat; T Hayek; L Reisin; S Rosenheck; B Lewis; R Zimlichman; A Weiss; A Marmor; Y Turgeman; E Klainman; A Francis; M Lahav; M Omary; M Morris; C Olivieri; M Santonastaso; R Fenici; L Mos; A Ghirarduzzi; R De Caterina; S Novo; E Richiardi; S Testa; M Pini; A D'Angelo; A Barsotti; M Donati; M Chiariello; M Galli; G Casolo; L Moretti; Y Atsushi; K Yamamoto; S Goto; H Kihara; T Akihiko; T Saito; H Yoshii; T Sasaki; M Suwa; S Adachi; K Usada; Y Nakamura; K Hayashida; T Yamada; T Iwasawa; Y Kawase; K Sugi; T Murakami; K Satake; T Iwao; K Maemura; Y Koretsune; Y Tsubokou; M Yamashita; Y Sato; F Kouichi; S Yura; A Matsushima; K Iwade; S Kamakura; S Tanaka; H Murata; S Yamamoto; Y Kobayashi; Y Higashi; T Shinozaki; H Ikeda; T Hisaoka; K Node; H Takagi; T K Ong; I Z Abidin; Z Yusof; K Yusoff; O Maskon; M De los Rios Ibarra; M Alcocer Gamba; E Lopez Rosas; C Calvo Vargas; P Fajardo Campos; J Alejandro Cordero-Cabra; C JerJes-Sanchez; I Hernandez Santamaria; L Molina; R Olvera Ruiz; C Arean Martinez; J Gonzalez Guerra; I Morales Gonzalez; J Cervantes-Escarcega; E Julian Chuquiure-Valenzuela; C Riojas; J Gonzalez Hermosillo; A Galicia; P Nierop; F Verheugt; M Daniels; D Lok; A Alings; M Scholten; J Plomp; R Derksen; A Bredero; P Zwart; A Schaap; H Michels; C Van der Zwaan; J Hysing; S Elle; T Omland; P Rønnevik; B Øie; J E Otterstad; N Bogale; T Kjærnli; S Halvorsen; B Bryhni; K Vikenes; W Cabrera; A Rodriguez; C Chavez; R Gamboa; L Segura; O Araoz; R Azanero; L Toce; F Medina; G Bustamante; C Rios Vasquez; M Zubiate; F Collado; E Morales-Palomares; R Sy; D Morales; G Rogelio; M T Abola; E Ramos; M Yamamoto; F De Leon; N Abelardo; G Kania; M Szpajer; M Rajzer; M Janion; M Bronisz; W Ruzyllo; M Piepiorka; M Wendland; T Czerski; R Korzeniak; A Budaj; L Wawrzynska; M Ogorek; P Miekus; W Tracz; A Ocicka-Kozakiewicz; J Stepinska; Z Kiedrowicz; T Pasierski; J Kasprzak; M Galewicz; B Podogrodzka; M Krauze-Wielicka; A Chmielinski; A Boruczkowska-Kaszkowiak; W Piotrowski; D Vinereanu; S Stamate; M Cinteza; C Mihaela Tanaseanu; G Andrei Dan; I Benedek; R M Ionescu; D Lighezan; A Salajan; E Carasca; R Capalneanu; C Pop; C G Fierbinteanu-Braticevici; D Tudor Zdrenghea; D Gaita; I Manitiu; T Nanea; C Arsenescu Georgescu; P Chizhov; A Kastanayan; V Oleynikov; T Treshkur; A Govorin; T Zhelninova; O Barbarash; T Novikova; O Reshetko; E Sivkova; A Obrezan; E Panchenko; S Popov; A Ivleva; D Zotov; A Gordienko; G Kamalov; I Chernichka; A Levin; K Zrazhevsky; S Golitsyn; N Shilkina; A Golovach; G Filonenko; S Bondarev; V Orlov; A Bragina; N Koziolova; A Svistov; S Shustov; I Libov; O Kisliak; E Privalova; O Aleksandrov; E Mazur; Y Karpov; D Belenky; V Kostenko; Y Shubik; M Ruda; G Arutyunov; V Eltishcheva; B Sidorenko; R Oseshnyuk; M Boyarkin; Y Pozdnyakov; N Staxhinskiy; A Sinopalnikov; S Yakushin; A Koniakhin; N Yarohno; Z Sizova; V Zadionchenko; I Klimov; D Duplyakov; S Kanorsky; V Mareev; V Terekhov; V Arkhipov; T Sotnikova; V Yakusevich; V Lesnov; I Gordeev; N Gratsiansky; S Shalaev; V Sulimov; O Talibov; E Zemtsovsky; O Azarin; R S Tan; J Thorne; D De Jong; M Basson; L van Zyl; P Commerford; H Weich; E van Nieuwenhuizen; J Roos; D Kelbe; J Viljoen; T J Hong; B H Oh; K S Park; M H Jeong; C Y Rhim; D J Choi; J H Sung; Y N Kim; J H Bae; S J Tahk; K H Ryu; S U Kwon; T H Rho; T J Cha; D G Shin; P Álvarez García; M Vida; E Galve; J Bruguera; J Roquer; F Olías de la Cruz; M A Paz Bermejo; T Segura; J H Gómez Gómez; A Ugarriza; I Plaza Pérez; J Villacastin; V Bertomeu; R Vargas; J Serena Leal; J Egido Herrero; A Bethencourt González; X Albert; C Gonzalez Juanatey; V Medrano; J Vivancos; T Andersson; C J Lindholm; F Al-Khalili; C Höglund; M Rosenqvist; O Bergström; J Herlitz; G Rasmanis; L Johansson; C Christersson; O Fredholm; M Callander; H Po; J P Pan; C D Tseng; K G Shyu; S H Chu; H Kultursay; B Gorenek; C Erol; G Lip; M Albazzaz; H Kadr; A Cohen; J Cooke; A Agarwal; M Brack; M Pye; M Anderson; F Dunn; Y K Wong; S Glen; G Ford; A Alwail; Z Yousef; M Blagden; D Murdoch; G McInnes; J Camm; W Ridsdill Smith; J J V McMurray; J Webster; D Dutka; B McClements; T Levy; S Yogasundram; A Moriarty; M McCullagh; J Flather; M Gumbley; I Findlay; J Davies; A Cooke; A Ahsan; J Cannon; A Bakhai; A Jacob; T Trouton; A Ajala; A Bartkowiak; D Humiston; W Kufs; K Klancke; P Jetty; D Gupta; V Nadar; K Yousuf; G Sosa-Suarez; S Gill; M Wukelic; N Mayer; D Colan; E Haskel; P Grena; W Haught; R Walsh; K Carr; N Tahirkheli; M Jardula; J Cebe; S Bloom; S Bilazarian; R Gilmore; N Jaffrani; D Goldscher; A Lebowitz; I Friedlander; M Stein; S Promisloff; A Magnano; J Dean; J Gerber; D Perloff; Y Cohen; A Meholick; T Tobin; R Acheatel; P Levanovich; J Ip; J Porterfield; N Seshadri; M McKenzie; A Alfieri; R Gazmuri; B Beanblossom; D Van Hamersveld; J McCriskin; M Gelernt; W Bowden; C Sotolongo; J Lang; S Kaatz; F Agnone; D Hassman; E Flores; F Albrecht; C Hassel; J Quartner; J LaFata; N Bedwell; W Herzog; J Amin; J Usedom; A Brockmyre; R Abadier; C Corder; R Marple; C Lovell; W Henry 3rd; A Chhabra; S Baker; R Bedoya; R Sandoval; M Nathan; D Garcia; K Vora; S Sloan; E Kosinski; R Foster; A Salacata; R Weachter; C Bredlau; P Mehta; C Russo; R Swint Sr; S Rosenthal; K Bybee; B Peart; P Chaudhuri; B Iteld; M Staab; D Rhodes; J Kappler; M Mandviwala; O Niedermaier; C Sofley; M Heiman; S Gips; R Harris; C East; V Nguyen; R Huling; U Thadani; D Travis; F Maislos; M West; R Castello; K Cohen; R Karlsberg; J Schmedtje Jr; D Gottlieb; A MacKinnon; G Noble; P O'Neill; J Roth; J Kobayashi; M Honan; G Hanovich; S Ehrlich; W Wilson; A Warner; A Rubin; E Rivera; S Leu; L Smith; J Agaiby; M Jan; R Gould; S Weiner; J Fleming; J Hemphill; K Parr; M Stoddard; P Curran; K Kurrelmeyer; V Desai; D Kereiakes; E Schwarz; M Lillestol; J Vazquez-Tanus; R Vicari; J White; R Shroff; R Fierer; N Vijay; A Hamad; M Kozinn; D Young; S Fenton; P Ouyang; A Wellford; P Zwerner; P Meyer; J Foley; A Boyle; M Dotani; A Skolnick; C Rodriguez-Fierro; B Hattler; M Rubin; P Hartley; L Tami; E Ball; C McPherson; S Eisenberg; I Niazi; M Orlov; B Bachhuber; C Massey; W Phillips; E Mouhayar; J Griffin; E Blumberg; S Slabic; K Danisa; A Samal; S Rohrbeck; P McCullough; D Dohan; G Aycock; A Jones; J Anderson; R Silverman; W Smith; D Mishkel; N Patterson; H Moore; A Kabour; M Muttreja; W Jaffrani; T Vidic; S Kent; B Platt; R Goldberg; S Kulback; R Patel; A Bazzi; S Goldman; A Roman; C Levin; B Lachterman; Y Chandrashekhar; I Aisiku; C Powers; E Engeron; R Bernstein; S Shah; J Strobel; H Punatar; R Garcia; D Linden; A Al-Mudamgha; A Quick; J Kramer; G Feldman; D Stapleton; M Davis; J Graff; J Galizia; P Wassmer; D Chiu; R Ison; K Curry; M Finneran; A Solomon; B Schifferdecker; J Seger; A Alexander; S Yates; R Ashley Jr; J Cordero-Sepulveda; P Cowen; T Ayres; B Kowalski; S Anton; J Phillips; D Donovan; A Patel; R Smith; J Updegrove; A Buxton; D Clark; J Margolis; G Brooks; R Pernenkil; J Walters; M Richards; P Maccaro; M Pieniek; J Garcia Pulido; C W Lee; J Ilvento; D Riff; B Blue; J Welker; H Karunaratne; P Santucci; M Vatutin; I Kraiz; Y Mostovoy; O Karpenko; V Tseluyko; L Kononenko; V Volkov; A Parkhomenko; G Popik; I Chopey; Y Burmak; S Pavlyk; V Vizir; O Barna; O Sychov; I Vykhovanyuk; V Tashchuk; I Khomazjuk; S Andrievskaya; Z Telyatnikova; O Bondarchuk; V Netiazhenko; N Seredyuk; O Koval; I Kovalsky; A Bazylevych; G Lysenko; M Borschivsky; A Yagensky; G Dzyak; I Bereznyakov; L Rudenko; G Ignatenko; K Amosova; O Voloshyna; L Ivanova; S Tykhonova; E Suprun
Contributors:	C. B., Granger; J. H., Alexander; J. J. V., Mcmurray; R. D., Lope; E. M., Hylek; M., Hanna; H. R., Al-Khalidi; J., Ansell; D., Atar; A., Avezum; M. C., Bahit; R., Diaz; J. D., Easton; J. A., Ezekowitz; G., Flaker; D., Garcia; M., Geralde; B. J., Gersh; S., Golitsyn; S., Goto; A. G., Hermosillo; S. H., Hohnloser; J., Horowitz; P., Mohan; P., Jansky; B. S., Lewi; J. L., Lopez-Sendon; P., Pai; A., Parkhomenko; F. W. A., Verheugt; J., Zhu; Collaborators ARISTOTLE Committees and Investigators: Christopher B Granger, Wallentin L.; Wallentin, Lar; H Alexander, John; Ansell, Jack; Diaz, Rafael; Donald Easton, J; J Gersh, Bernard; Hanna, Michael; Horowitz, John; M Hylek, Elaine; V McMurray, John J; Mohan, Puneet; A Verheugt, Freek W; Cecilia Bahit, M; Aylward, Philip; Amerena, John; Huber, Kurt; Bartunek, Jozef; Avezum, Alvaro; A Ezekowitz, Justin; Dorian, Paul; Lanas, Fernando; Lisheng, Liu; Zhu, Jun; Isaza, Daniel; Jansky, Petr; Husted, Steen; Pekka Harjola, Veli; Gabriel Steg, Philippe; H Hohnloser, Stefan; Keltai, Matya; Pais, Prem; Xavier, Deni; S Lewis, Basil; De Caterina, Raffaele; Goto, Shinya; G Hermosillo, Antonio; W Alings, Antonio M; Atar, Dan; Segura, Lui; Ruzyllo, Witold; Vinereanu, Drago; Varshavsky, Sergei; Golitsyn, Sergey; Oh, Byung-Hee; Commerford, Patrick; Luis Lopez-Sendon, Jose; Rosenquist, Marten; Erol, Cetin; Parkhomenko, Alexander; Flaker, Greg; Garcia, David; A Pfeffer, Marc; Diener, Hans-Christoph; Maggioni, Aldo; Pocock, Stuart; Rouleau, Jean-Lucien; Wyse, George; Hatch, Lisa; Banks, Missy; Handler, Allison; Yang, Hongqiu; Garg, Jyotsna; Griffith, Keven; Burr, Andrew; Dremsizov, Tony; Vidal, Joan
Publication Year:	2011
Collection:	IRIS UNIPV (Università degli studi di Pavia)
Subject Terms:	Aged; Anticoagulant; Atrial Fibrillation; Double-Blind Method; Female; Follow-Up Studie; Hemorrhage; Human; International Normalized Ratio; Kaplan-Meier Estimate; Male; Middle Aged; Pyrazole; Pyridone; Stroke; Thromboembolism; Treatment Outcome; Warfarin; Factor Xa Inhibitors
Description:	BACKGROUND: Vitamin K antagonists are highly effective in preventing stroke in patients with atrial fibrillation but have several limitations. Apixaban is a novel oral direct factor Xa inhibitor that has been shown to reduce the risk of stroke in a similar population in comparison with aspirin. METHODS: In this randomized, double-blind trial, we compared apixaban (at a dose of 5 mg twice daily) with warfarin (target international normalized ratio, 2.0 to 3.0) in 18,201 patients with atrial fibrillation and at least one additional risk factor for stroke. The primary outcome was ischemic or hemorrhagic stroke or systemic embolism. The trial was designed to test for noninferiority, with key secondary objectives of testing for superiority with respect to the primary outcome and to the rates of major bleeding and death from any cause. RESULTS: The median duration of follow-up was 1.8 years. The rate of the primary outcome was 1.27% per year in the apixaban group, as compared with 1.60% per year in the warfarin group (hazard ratio with apixaban, 0.79; 95% confidence interval [CI], 0.66 to 0.95; P
Document Type:	article in journal/newspaper
Language:	English
Relation:	info:eu-repo/semantics/altIdentifier/pmid/21870978; info:eu-repo/semantics/altIdentifier/wos/WOS:000294857300006; volume:365; issue:11; firstpage:981; lastpage:992; numberofpages:12; journal:NEW ENGLAND JOURNAL OF MEDICINE; http://hdl.handle.net/11571/1341368
DOI:	10.1056/NEJMoa1107039
Availability:	http://hdl.handle.net/11571/1341368; https://doi.org/10.1056/NEJMoa1107039
Accession Number:	edsbas.28BC68CF
Database:	BASE