| Title: |
OS08.4.A Analysis of melanoma brain metastasis immune microenvironment through multiplex gene expression profiling |
| Authors: |
Ricci, A A; Collemi, G; Orlando, G; Tampieri, C; Senetta, R; Pellerino, A; Bruno, F; Melcarne, A; Garbossa, D; Rudà, R; Soffietti, R; Ribero, S; Quaglino, P; Cassoni, P; Bertero, L |
| Source: |
Neuro-Oncology ; volume 24, issue Supplement_2, page ii19-ii19 ; ISSN 1522-8517 1523-5866 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2022 |
| Description: |
Background Novel immunotherapies based on targeting of specific immune checkpoints enabled a significant improvement of melanoma outcome, but melanoma brain metastases (BM) remain an unmet oncological need with an overall 2-year survival rate lower than 10%. Tumour immune microenvironment has been demonstrated to play a key role in BM establishment and development, but data regarding the specific milieu of melanoma BM is limited. Material and Methods Gene expression profiles of 55 samples of primary melanoma and BM were evaluated using the nCounter PanCancer IO 360 Panel (NanoString Technologies) targeting 770 mRNA involved in tumor immune microenvironment modulation. The case series consisted of 10 primary melanomas and their 10 matched BM, 25 unmatched BM, and 10 locally advanced control melanomas without evidence of BM after >5 year follow up. Results Among BM samples, most patients (25/45) were males and median age at BM diagnosis was 61,2 years with a median time to BM development of 2,1 years. Median OS from BM diagnosis was 1,3 years. Several genes resulted significantly downregulated in BM compared to primary melanomas, including SERPINB5 (p |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1093/neuonc/noac174.058 |
| Availability: |
https://doi.org/10.1093/neuonc/noac174.058; https://academic.oup.com/neuro-oncology/article-pdf/24/Supplement_2/ii19/45691812/noac174.058.pdf |
| Rights: |
https://academic.oup.com/pages/standard-publication-reuse-rights |
| Accession Number: |
edsbas.291967C9 |
| Database: |
BASE |